Liao John B 5 17 17 uncropped

John B Liao, MD, PhD

Assistant Professor

 
Joined UW Medicine:

9/1/2010

Clinical Focus:

Gynecologic Oncology:
• Complex gynecologic oncology surgery
• Treatment of gynecologic cancers
• Clinical trials for gynecologic cancers
• Immunotherapy for gynecologic malignancies
• Robotic surgery

Licensure:

Washington, 2010

Certification:

Obstetrics and Gynecology, 2011
Active Candidate for Subspecialty Board Certification in Gynecologic Oncology

Education:

• MD Degree
   (George Washington University School of Medicine, 1998)
• PhD Degree in Investigative Medicine 
   (Yale University, 2007)
• Residency in Obstetrics and Gynecology
   (George Washington University Medical Center, 2002)
• Postdoctoral Fellow, Molecular Oncology and Virology
   (Yale University School of Medicine, 2004)
• Fellowship in Gynecologic Oncology
   (University of Pennsylvania School of Medicine, 2010)

Research Interests:

• Immunotherapy for gynecologic malignancies
• Clinical trials

Current Research:

• A phase II study of concurrent IGFBP-2 vaccination and neoadjuvant chemotherapy to increase the rate of pathologic complete response at the time of cytoreductive surgery
• Phase I/II study of anti-PD-1 therapy in combination with platinum chemotherapy for platinum resistant ovarian, fallopian tube, and primary peritoneal cancer
• Immune profiling of BRCA1 and platinum resistance in ovarian cancer

Memberships:

• American Association for Cancer Research
• American Congress of Obstetricians and Gynecologists
• Society for Immunotherapy of Cancer
• Society of Gynecologic Oncology

Selected Publications:

Johnson N, Liao JB. Novel Therapeutics for Ovarian Cancer: The 11th Biennial Rivkin Center Ovarian Cancer Research Symposium. Int J Gynecol Cancer. 2017 Oct 17. doi: 10.1097/IGC.0000000000001115. [Epub ahead of print] PubMed PMID: 29040190.

Shah CA, Beck T, Liao JB, Giannakopoulos NV, Veljovich D, Paley P. Surgical and oncologic outcomes after robotic radical hysterectomy as compared to open radical hysterectomy in the treatment of early cervical cancer. J Gynecol Oncol. 2017 Nov;28(6):e82. doi: 10.3802/jgo.2017.28.e82. PubMed PMID: 29027400; PubMed Central PMCID: PMC5641532.

Goff BA, Agnew K, Neradilek MB, Gray HJ, Liao JB, Urban RR. Combining a symptom index, CA125 and HE4 (triple screen) to detect ovarian cancer in women with a pelvic mass. Gynecol Oncol. 2017 Aug 28. [Epub ahead of print] PMID: 28860006

Morse CB, Elvin JA, Gay LM, Liao JB. Elevated tumor mutational burden and prolonged clinical response to anti-PD-L1 antibody in platinum-resistant recurrent ovarian cancer. Gynecol Oncol Rep. 2017 Jun 27;21:78-80. doi: 10.1016/j.gore.2017.06.013. eCollection 2017 Aug.

Liao JB, Swensen RE, Ovenell KJ, Hitchcock-Bernhardt KM, Reichow JL, Apodaca MC, D'Amico L, Childs JS, Higgins DM, Buening BJ, Goff BA, Disis ML. Phase II trial of albumin-bound paclitaxel and granulocyte macrophage colony-stimulating factor as an immune modulator in recurrent platinum resistant ovarian cancer. Gynecol Oncol. 2017 Mar;144(3):480-485. doi: 10.1016/j.ygyno.2017.01.008. Epub 2017 Jan 12.

Martin JY, Urban RR, Liao JB, Goff BA. Bevacizumab toxicity in heavily pretreated recurrent epithelial ovarian, fallopian tube, and primary peritoneal cancers. J Gynecol Oncol. 2016 Sep;27(5):e47. doi: 10.3802/jgo.2016.27.e47. Epub 2016 May 10. PubMed PMID: 27329195.

Liao JB. Immunotherapy for gynecologic cancers. Gynecol Oncol. 2016 Jul;142(1):3-5. doi: 10.1016/j.ygyno.2016.05.029. Epub 2016 Jun 16. PubMed PMID: 27242186.

Beck TL, Morse CB, Gray HJ, Goff BA, Urban RR, Liao JB. Route of hysterectomy and surgical outcomes from a statewide gynecologic oncology population: is there a role for vaginal hysterectomy? Am J Obstet Gynecol. 2016 Mar;214(3):348.e1-9. doi: 10.1016/j.ajog.2015.10.006. Epub 2015 Oct 22.

Liao JB, Ovenell KJ, Curtis EEM, Cecil DL, Koehnlein MR, Rastetter LR, Gad EA, Disis ML.   Preservation of tumor-host immune interactions with luciferase-tagged imaging in a murine model of ovarian cancer.  J Immunother Cancer 2015 May 19;3:16.  PMID: 25992288

Liao JB, Yip YY, Swisher EM, Agnew K, Hellstrom KE, Hellstrom I.  Detection of the HE4 protein in urine as a biomarker for ovarian neoplasms: clinical correlates.  Gynecol Oncol 2015Apr 9.  PMID: 25866324

Liao JB and Disis ML.  Therapeutic vaccines for ovarian cancer.  Gynecol Oncol.  2013. Sep;130(3):667-73.  PMID: 23800697

Dao MD, Alwan LM, Gray HJ, Tamimi HK, Goff BA,  Liao JB.  Recurrence patterns after extended treatment with bevacizumab for ovarian, fallopian tube, and primary peritoneal cancers.  Gynecol Oncol 2013 Aug;130(2):295-9. PMID: 23632207

Tanyi JL, McCann G, Hagemann AR, Coukos G, Rubin SC, Liao JB, Chu CS. Clinical predictors of bevacizumab-induced gastrointestinal perforation. Gynecol Oncol Mar 2011;120(3):464-9.

Liao JB, Jean S, Wilkinson-Ryan I, et al. Vaginal intraepithelial neoplasia (VAIN) after radiation therapy for gynecologic malignancies: A clinically recalcitrant entity. Gynecol Oncol Jan 2011;120(1):108-12.

Kandalaft LE, Singh N, Liao JB, et al. The emergence of immunomodulation: Combinatorial immuno-chemotherapy opportunities for the next decade. Gynecol Oncol Feb 2010;116(2):222-3.

Robinson BL, Liao JB, Adams SF, Randall TC. Vaginal cuff dehiscence after robotic total laparoscopic hysterectomy. Obstet Gynecol Aug 2009;114(2 Part 1):369-71.

Liao JB, Publicover J, Rose JK, DiMaio D. Single-dose therapeutic vaccination of mice with vesicular stomatitis virus expressing human papillomavirus type 16 E7 protein. Clin Vaccine Immunol May 2008;15(5):817-24.

Liao JB. Viruses and human cancer. Yale J Biol Med 2006;79(3-4):115-22.

DiMaio D, Liao JB. Human papillomaviruses and cervical cancer. Adv Virus Res 2006;66:125-59.

Liao JB, Buhimschi CS, Norwitz ER. Normal labor: Mechanism and duration. Obstet Gynecol Clin N Am Jun 2005;32(2):145-64.

Liao JB, Lin JY. Estrogen receptor expression in an endometrial stromal sarcoma after tamoxifen therapy. Eur J Gynaec Oncol 2001;22:417-9.

Chi DS, Liao JB, Leon LF, et al. Identification of prognostic factors in advanced epithelial ovarian carcinoma. Gynecol Oncol 2001;82:532-7.

Appointments & Practice Locations

UW Medical Center 8SE Oncology
Cascade Tower, 8th floor
1959 NE Pacific Street
Seattle, WA 98195

Appointments:   206.598.8300