Norquist Barbara Dept web

Barbara S Norquist, MD

Assistant Professor
Nancy Kelley Jensen Endowed Faculty Fellowship in Gynecologic Oncology Research

Dr. Norquist’s presentation on Ovarian Cancer Outcomes and DNA Repair Genes presented at the annual meeting of the Society of Gynecologic Oncology 2016

Joined UW Medicine:


Clinical Focus:

Gynecologic Oncology
• Gynecologic malignancies
• Minimally invasive surgery
• Risk-reducing surgery
• Robotic surgery


Washington, 2008


• Obstetrics and Gynecology, 2014
• Gynecologic Oncology, 2015


• MD Degree
   (University of Washington, 2004)
• Residency in Obstetrics and Gynecology
   (University of Washington, 2008)
• Fellowship in Gynecologic Oncology
   (University of Washington, 2012)

Research Interests:

• Genetics of ovarian cancer
• BRCA1 and BRCA2 mutation
• Pathogenesis of ovarian cancer


• American Congress of Obstetricians and Gynecologists
• American Association for Cancer Research
• Society for Obstetricians and Gynecologists of Canada

Selected Publications:

Norquist BM, Garcia R, Allison K, Jokinen C, Kernochan L, Pizzi C, Barrow B, Goff B, Swisher E. The molecular pathogenesis of hereditary ovarian carcinoma: alterations in the tubal epithelium of women with BRCA1 and BRCA2 mutations.  Cancer 2010, Nov 15:116(22):5261-71.

Norquist BM, Wurz K, Pennil C, Garcia R, Gross J, Sakai W, Karlan B, Taniguchi T, Swisher E. Secondary somatic mutations restoring BRCA1/2 predict chemotherapy resistance in hereditary ovarian carcinomas. J Clin Oncol 2011, Aug 1:29(22);3008-15.

Walsh T, Casadei S, Lee MK, Pennil CC, Nord AS, Thornton AM, Roeb W, Agnew KJ, Stray SM, Wickramanayake A, Norquist BM, Pennington KP, Garcia RL, King MC, Swisher EM. Mutations in 12 genes for inherited ovarian, fallopian tube, and peritoneal carcinoma identified by massively parallel sequencing. Proc Natl Acad Sci USA 2011 Nov 1;108(44):18032-7.

Norquist BM, Pennington KP, Agnew KJ, Harrell MI, Pennil CC, Lee MK, Casadei S, Thornton AM, Garcia RL, Walsh T, Swisher EM. Characteristics of women with ovarian carcinoma who have BRCA1 and BRCA2 mutations not identified by clinical testing. Gynecol Oncol 2013 Mar;128(3):483-7. PMID: 23262210.

Pennington KP, Walsh T, Harrell MI, Lee MK, Pennil C, Rendi M, Thornton A, Norquist BM, et al.  Germline and somatic mutations in homologous recombination genes predict platinum response and survival in ovarian, fallopian tube, and peritoneal carcinomas.  Clin Cancer Res 2014 Feb 1;20(3):764-75. PMID: 24240112.

Norquist BM, Harrell MI, Brady MF, Walsh T, Lee MK, Gulsuner S, Bernards SS, Casadei S, Yi Q, Burger RA, Chan JK, Davidson SA, Mannel RS, DiSilvestro PA, Lankes HA, Ramirez NC, King MC, Swisher EM, Birrer MJ. Inherited mutations in women with ovarian carcinoma. JAMA Oncology 2016 Apr;2(4):482-90. PMID: 26720728.

Appointments & Practice Locations

UW Medical Center 8SE Oncology
Cascade Tower, 8th floor
1959 NE Pacific Street
Seattle, WA 98195

Appointments:   206.598.8300