Dorothy Patton

Dorothy L Patton, PhD

Professor

 
Education:

• BS, Biology (University of Puget Sound, 1971)
• MS, Biology (University of Puget Sound, 1973)
• PhD, Biological Structure (University of Washington, 1981)

Research Interests:

• Sexually transmitted infections (STI's)—Chlamydia trachomatis,
   Trichomonas vaginalis, Mycoplasma genitalium

• Pathogenesis of PID and infertility
• Evaluating topical microbicides for vaginal/rectal application
• Topical microbicides: post-coital assessments
• Vaccines for C. trachomatis

Current Research:

• Improved Macaque Safety Model for Topical Microbicides: Post-coital Assessments
• Topical Microbicide Safety and Efficacy Evaluation in Non-human Primates
• Project 2—Nonhuman Primate Studies of Tenofovir and Dapivirine
• Safety and Efficacy of Chlamydia Vaccine Candidates

Memberships:

• American Sexually Transmitted Disease Association
• American Society of Microbiology
• Infectious Diseases Society of Obstetrics and Gynecology
• Pacific Coast Reproductive Society
• Phi Sigma Society

Selected Publications:

Cosgrove Sweeney YT, Angeles RO, Cummings PK, Smith AD, Patton DL. Pigtailed Macaque model refinement: topical microbicide safety in the presence of coitus. J Med Primatol. Mar 28, 2011. doi: 10.1111/j.1600-0684.2011.00478.x. PMID:21443565. PMCID: PMC3128681

Bell JD, Bergin IL, Harris LH, Chai D, Muller I, Mwenda J, Dalton VK, Vahratian AM, LeBar B, Zochowski M, Kiulia N, Aronoff DM, Patton DL. The effects of a single cervical inoculation of Chlamydia trachomatis on the female reproductive tract of the baboon (Papio anubis). J Infect Dis 2011;204(9):130512. doi:10.1093/infdis/jir541 PMC3218649

Henning T, Fakile Y, Phillips C, Sweeney E, Mitchell J, Patton DL, Sturdevant G, Caldwell HD, Secor WE, Papp J, Hendry RM, McNicholl J, Kersh E. Development of a pigtail macaque model of sexually transmitted infection/HIV coinfection using Chlamydia trachomatis, Trichomonas vaginalis and SHIV SF162P3. J Med Primatol, 40(2011) 214-223. doi:10.1111/j.1600-0684.2011.00488.x PMC3402033

Bell JD, Bergin IL, Schmidt K, Zochowski MK, Aronoff DM, Patton DL. Non-human primate models used to study pelvic inflammatory disease caused by Chlamydia trachomatis. Infect Dis in Obstet & Gynecol. 2011 (2011) 675360. Epub 2011 Aug 17Article ID 675360. doi:10.1155/2011/675360. PMC3160047

Patton DL. A guide for standardizing colposcopic observations for the evaluation of topical microbicide products in the pigtailed macaque model. J Med Primatol. 41:48-51, 2012. doi:10.1111/j.1600-0684 2011.00516x PMC4207258

Zhou T, Hu M, Pearlman A, Patton D, Rohan L:  Expression and localization of P-glycoprotein, Multidrug Resistance Protein, and Breast Cancer Resistance Protein in the female lower genital tract of human and pigtailed macaque.   AIDS Research and Human Retroviruses. 2014 Jun 12. [Epub ahead of print]. PMID:  24803409 PMC4212939

Henning T, Butler K, Hanson D, Studevant G, Ellis S, Sweeney EM, Mitchell J, Deyonks F, Phillips C, Farshy C, Fakile Y, Papp J, Secor E, Caldwell H, Patton DL, McNicholl, Kersh E:  Increased Susceptibility to Vaginal SHIV Transmission in Pigtail Macaques Coinfected with Chlamydia trachomatis and Trichomonas vaginalis  J Infect Dis 2014 Oct 21; 210 (8):  1239-47. Epub 2014 April 21 PMID: 24755433  PMC 4271071. (This paper has been nominated for the Charles C Shepard Science Award, the highest award given by the CDC for scientific merit.)

Patton DL, Teng A, Randall A, Liang X, Felgner PL, de la Maza L:  Whole genome identification of C. trachomatis immunodominant antigens after gentiatl tract infections and effect of antibiotic treatment of pigtailed macaques. J Proteomics: 2014 108; 99-109 PMID:  24862987  PMC 4112733

Fernandez-Romero JA, Deal C, Herold BC, Schiller J, Patton D, Zydowsky T, Romano J, Petro CD, Lusti-Narasimhan M:  Multi-Purpose Prevention Technologies:  The Future of HIV and STIs Protection.   Trends in Microbiology 2015 DOI:  http//dx.doi.org/10.1016/j.tim.2015.02.006 PMID:  25759332

Vishwanathan SA, Morris MR, Wolitski RJ, RoseCE, Luo W,  Rose CE, Blau DM, Tsegaye T, Zaki SR, Garber DA, Jenkins LT, Henning TC, Patton DL,  Hendry RM, McNicholl JM, Kersh EN:  Rectal Application of a Highly Osmolar Personal Lubricant in a Macaque Model     Induces Acute Cytotoxicity but Does Not Increase Risk of SHIV infection.   PloS One  10(4):  e0120021.doi: 10.1371/journal.pone.0120021 April 8, 2015 PMID:  25853710