Patton Dot Dept web

Dorothy L Patton, PhD

Professor

 
Education:

• BS, Biology (University of Puget Sound, 1971)
• MS, Biology (University of Puget Sound, 1973)
• PhD, Biological Structure (University of Washington, 1981)

Research Interests:

• Sexually transmitted infections (STI's)—Chlamydia trachomatis,
   Trichomonas vaginalis, Mycoplasma genitalium

• Pathogenesis of PID and infertility
• Evaluating topical microbicides for vaginal/rectal application
• Topical microbicides: post-coital assessments

Current Research:

• Improved Macaque Safety Model for Topical Microbicides: Post-coital Assessments
• Topical Microbicide Safety and Efficacy Evaluation in Non-human Primates
• Project 2—Nonhuman Primate Studies of Tenofovir and Dapivirine
• Safety and Efficacy of Chlamydia Vaccine Candidates

Memberships:

• American Sexually Transmitted Disease Association
• American Society of Microbiology
• Infectious Diseases Society of Obstetrics and Gynecology
• Pacific Coast Reproductive Society
• Phi Sigma Society

Selected Publications:

Patton DL, Cosgrove Sweeney YT, Paul KJ. A summary of preclinical topical microbicide vaginal safety and chlamydial efficacy evaluations in a pigtailed Macaque model. Sex Trans Dis 35(10):889-97, 2008. PMID: 18607310

Patton DL, Cosgrove Sweeney YT, Paul KJ. A summary of preclinical topical microbicide rectal safety and efficacy evaluations in a pigtailed macaque model. Sex Trans Dis 36(6):350-56, 2009. PMID: 19556929. PMCID: PMC2749653

Miyairi I, Ramsey KH, Patton DL. Duration of untreated chamydia infection and factors associated with clearance: review of animal studies. J Infect Dis 201(S2):S96-S103, 2010

Sassi AB, Cost MR, Cole AL, Cole AM, Patton DL, Gupta P, Rohan LC. Formulation development of Retrocyclin-1 (RC-101) as an anti-HIV vaginal microbicide product. In Press. Antimicrob Agents Chemother. 55(5):2282-9, 2011. PMID 21321138. doi:10.1128/AAC.01190-10

Cole AM, Patton DL, Rohan LC, Cole AL, Cosgrove Sweeney Y, Rogers NA, Sassi A, Tarwater P, Ruchia P, Lehrer RI, Waring AJ, Gupta P. The formulated microbicide RC-101 was safe and antivirally active following intravaginal application in pigtailed macaques. PloS ONE, 5(11):e15111.doi:10.137/journal.pone.0015111. 2010 PMID: 21124745

Cosgrove Sweeney YT, Angeles RO, Cummings PK, Smith AD, Patton DL. Pigtailed Macaque model refinement: topical microbicide safety in the presence of coitus. J Med Primatol. Mar 28, 2011. doi: 10.1111/j.1600-0684.2011.00478.x. PMID:21443565. PMCID: PMC3128681

Bell JD, Bergin IL, Harris LH, Chai D, Muller I, Mwenda J, Dalton VK, Vahratian AM, LeBar B, Zochowski M, Kiulia N, Aronoff DM, Patton DL. The effects of a single cervical inoculation of Chlamydia trachomatis on the female reproductive tract of the baboon (Papio anubis). J Infect Dis doi:10.1093/infdis/jir541

Henning T, Fakile Y, Phillips C, Sweeney E, Mitchell J, Patton DL, Sturdevant G, Caldwell HD, Secor WE, Papp J, Hendry RM, McNicholl J, Kersh E. Development of a pigtail macaque model of sexually transmitted infection/HIV coinfection using Chlamydia trachomatis, Trichomonas vaginalis and SHIV SF162P3. J Med Primatol, 40(2011) 214-223. doi:10.1111/j.1600-0684.2011.00488.x

Bell JD, Bergin IL, Schmidt K, Zochowski MK, Aronoff DM, Patton DL. Non-human primate models used to study pelvic inflammatory disease caused by Chlamydia trachomatis. Infect Dis in Obstet & Gynecol. 2011 (2011) 675360. Epub 2011 Aug 17Article ID 675360. doi:10.1155/2011/675360.

Patton DL. A guide for standardizing colposcopic observations for the evaluation of topical microbicide products in the pigtailed macaque model. J Med Primatol. In Press