Shailender Bhatia, MD
Department of Medicine
Division of Oncology
Seattle Cancer Care Alliance
825 Eastlake Ave E, G4-810
Seattle, WA 98109-1023
Specialty / Expertise
- Skin Cancers (Melanoma, Merkel Cell Cancer)
- Kidney Cancers
- Targeted therapy
Dr. Bhatia's research efforts are mostly focused on clinical trials that aim at improving outcomes in skin cancers (especially melanoma and Merkel cell carcinoma) and kidney cancers. He is especially interested in those novel therapeutic approaches that stimulate the immune system against cancer and those that target therapy to the tumors to spare unnecessary toxicity.
Current Research Projects
A phase II study of intratumoral injection of Interleukin-12 plasmid and in vivo electroporation in patients with Merkel Cell Cancer
A Multicenter Phase II Trial of intratumoral pIL-12 electroporation in advanced stage cutaneous and in transit malignant melanoma A Phase I Dose Escalation Study to Investigate the Safety, Pharmacokinetics, Immunoregulatory Activity, and Preliminary Antitumor Activity of BMS-982470 (Recombinant Interleukin 21, rIL-21) in combination with Ipilimumab in Subjects with Unresectable Stage III or Stage IV Melanoma
A Phase I/II Study of BNC105P in Combination with Everolimus or Following Everolimus For Progressive Metastatic Clear Cell Renal Cell Carcinoma Following Prior Tyrosine Kinase Inhibitors
An Exploratory Study of the Biologic Effects of BMS-936558 (Anti-PD-1 Monoclonal Antibody) Treatment in Subjects With Advanced Melanoma (Unresectable or Metastatic)
Dr. Bhatia received his MBBS (equivalent to MD) at the All India Institute of Medical Sciences, New Delhi, India. He completed his Internal Medicine Residency at the University of Connecticut Health Center, Farmington CT. He was a Post-Doctoral Fellow in Hematology-Oncology at the University of Washington/Fred Hutchinson Cancer Research Center, Seattle, WA.
Bhatia S., Moon J., Margolin K.A., Weber J.S., Lao C.D., Othus M., Aparicio A.M., Ribas A., Sondak V.K. Phase II Trial of Sorafenib in Combination with Carboplatin and Paclitaxel in Patients with Metastatic Uveal Melanoma: SWOG S0512. PLOS ONE 7(11): e48787. doi:10.1371/journal.pone.0048787. 2012.
Paulson K.G., Iyer J.G., Blom A., Warton E.M., Sokil M., Yelistratova L., Schuman L., Nagase K., Bhatia S., Asgari M.M., Nghiem P. Systemic Immune Suppression Predicts Diminished Merkel Cell Carcinoma-Specific Survival Independent of Stage. J Inves Dermatol. 2012 Nov 29. doi: 10.1038/jid.2012.388.
Brahmer J.R., Tykodi S.S., Chow L.Q., Hwu W.J., Topalian S.L., Hwu P., Drake C.G., Camacho L.H., Kauh J., Odunsi K., Pitot H.C., Hamid O., Bhatia S., et al. Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N Engl J Med. 2012 Jun 2.
Bhatia S., Thompson J.A. Systemic therapy for metastatic melanoma in 2012: dawn of a new era. J Natl Compr Canc Netw. 2012 Mar; 10(3):403-12.
Chapuis A.G., Thompson J.A., Margolin K.A., Rodmyre R., Lai I.P., Dowdy K., Farrar E.A., Bhatia S., Sabath D.E., Cao J., Li Y., Yee C. Transferred Melanoma-Specific CD8+ T Cells Persist, Mediate Tumor Regression and Acquire Central Memory Phenotype. Proc Natl Acad Sci, U.S.A. 2012 Mar 20; 109(12):4592-7. Epub 2012 Mar 5.
Bhatia S., Thompson J.A. Novel Cytokines for Melanoma. Targeted Therapeutics in Melanoma. 2012.
Bhatia S., Afanasiev O., Nghiem P. Immunobiology of Merkel cell carcinoma: implications for immunotherapy of a polyomavirus-associated cancer. Curr Oncol Rep. 2011 Dec; 13(6):488-97. Review.
Bhatia S., Tykodi S.S., Thompson J.A.. Treatment of Metastatic Melanoma: an overview. Oncology (Williston Park). 2009 May;23(6):488-96.
Bhatia S., Huber B.R., Upton M.P., Thompson J.A. Inflammatory enteric neuropathy with severe constipation after ipilimumab treatment for melanoma: a case report. J Immunother. 2009 Feb-Mar;32(2):203-5
Bhatia S., Thompson J.A. Temsirolimus in patients with advanced renal cell carcinoma: an overview. Adv Ther. 2009 26(1):55-67.
Thompson J.A., Curti B.C., Redman B.G., Bhatia S., Weber J.S., Agarwala S.S., Sievers E.L., Hughes S.D., DeVries T.A., Hausman D.F. Phase 1 Study of Recombinant Interleukin-21 in Patients with Metastatic Melanoma and Renal Cell Carcinoma. J Clin Oncol. 2008 Apr 20;26(12):2034-9 (currently #2 on website)
Bhatia S., Bauer F., Bilgrami S. Candidiasis - Associated Hemophagocytic Lymphohistiocytosis in Patient Infected with Human Immunodeficiency Virus. Clin Infect Dis. 2003 Dec 1;37(11):e161-6
Bhatia S, Bauer F, Bilgrami S. Candidiasis - Associated Hemophagocyctic Lymphohistiocytosis in Patient Infected with Human Immunodeficiency Virus. Clin Infect Dis 2003 Dec 1;37(11):e161-6.
Last updated: February 2013