Faculty

Larissa A. Korde, MD, MPH

Larissa A. Korde, MD, MPH

Assistant Professor
Department of Medicine
Division of Oncology

Mailing Address

Seattle Cancer Care Alliance
825 Eastlake Ave E, G3-630
Seattle, WA 98109

Admin Contact

Tabitha Headrick
206.288.6362
theadric@seattlecca.org
Fax: 206.288.2054

Specialty / Expertise

Breast cancer

Research Interests

While at the NCI, Dr, Korde worked on a number of clinical and epidemiologic studies focusing on individuals at increased risk for cancer. Her research focuses on applying epidemiologic methods and genetic knowledge to better understand and treat breast cancer and manage therapy-related toxicities. Dr. Korde has an interest in breast cancer prevention, and is involved in several studies assessing lifestyle interventions and chemoprevention in women at increased risk of breast cancer. She is also interested in assessing new modalities for the treatment of patients with early stage breast cancer. She is a member of the Gynecologic Oncology Group where her work focuses on studies that relate to women at increased risk for breast and ovarian cancer based on a genetic or familial predisposition, and the Southwest Oncology Group, where her interest is in managing early stage breast cancer and assessing and managing therapy-related toxicities.

Current Research Projects

Effect of Vitamin D and Weight Loss on Breast Tissue in Overweight / Obese Postmenopausal Women, Fred Hutchinson Cancer Research Center
(Principle Investigator) - Current

A Phase II Randomized Study of the Effect of Zoledronic Acid versus Observation on Bone Mineral Density of the Lumbar Spine in Women Who Elect to Undergo Risk-Reducing Surgery that Results in the Removal of Both Ovaries, Gynecologic Oncology Group (GOG 215)
(Co-Chair on National protocol) - Current

Mammographic Density Among Women at Increased Genetic Risk of Breast and Ovarian Cancer in the National Ovarian Cancer Prevention and Early Detection Study. Protocol approved for development by Gynecologic Oncology Group
(Principal Investigator) - Current

A Pilot Study of a Three Month Intervention for Increasing Physical Activity in Breast Cancer Survivors and Women at High Risk for Breast Cancer,  Medical Oncology Branch, Center For Cancer Research, NCI 
(Study Chairperson, 2004 - 2009) – Completed

Multidisciplinary Etiologic Study of Familial Testicular Cancer, Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, NCI
(Lead Investigator, 2006 - 2009) – Completed

A Trial of Exemestane in Postmenopausal Women with DCIS or at High Risk for Invasive Breast Cancer - Medical Oncology Branch, Center For Cancer Research, National Cancer Institute, Bethesda, MD
(Study Chairperson, 2006-2009) - Completed

Clinical, Genetic, Behavioral, Laboratory and Epidemiologic Characterization of Individuals and Families at High Risk of Breast/Ovarian Cancer –Division of Cancer Epidemiology and Genetics, NCI
(Associate Investigator, 2006-2009) - Completed

Training

Dr. Korde is an Assistant Professor in the Division of Medical Oncology and specializes in the care of breast cancer patients. She received a BA. from the College of William and Mary in 1992, an MD from New York Medical College in 1998, and a Masters degree in public health from the George Washington University in 2003. Dr. Korde completed her residency in Internal Medicine at Georgetown University Medical Center, and completed her Medical Oncology fellowship and a Cancer Prevention fellowship at the NCI, and then joined the Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, NCI as a staff clinician. Dr. Korde joined the Breast Medical Oncology faculty at the Seattle Cancer Care Alliance in July 2009.

Selected Publications

Korde LA, Mueller CM, Loud JT, Struewing JP, Nichols K, Greene MH, Mai PL. No evidence of excess breast cancer risk among mutation-negative women from BRCA mutation-positive families. Breast Cancer Res Treat. 2011 Jan;125(1):169-73. Epub 2010 May 11.

Korde LA, Gralow JR. Are bisphosphonates ready for the adjuvant setting? Oncology (Williston Park). 2010 May;24(6):480, 485. No abstract available.

Mirabello L, Savage SA, Korde L, Gadalla SM, Greene MH. LINE-1 methylation is inherited in familial testicular cancer kindreds. BMC Med Genet. 2010 May 17;11:77. Korde LA, Zujewski JA, Kamin L, Giordano S, Domchek S, Anderson WF, Bartlett JM, Gelmon K, Nahleh Z, Bergh J, Cutuli B, Pruneri G, McCaskill-Stevens W, Gralow J, Hortobagyi G, Cardoso F. Multidisciplinary meeting on male breast cancer: summary and research recommendations. J Clin Oncol. 2010 Apr 20;28(12):2114-22. Epub 2010 Mar 22.

Greene MH, Kratz CP, Mai PL, Mueller C, Peters JA, Bratslavsky G, Ling A, Choyke PM, Premkumar A, Bracci J, Watkins RJ, McMaster ML, Korde LA. Familial testicular germ cell tumors in adults: 2010 summary of genetic risk factors and clinical phenotype. Endocr Relat Cancer. 2010 Mar 8;17(2):R109-21. Print 2010 Jun. Review.

Korde LA, Lusa L, McShane L, Lebowitz PF, Lukes L, Camphausen K, Parker JS, Swain SM, Hunter K, Zujewski JA. Gene expression pathway analysis to predict response to neoadjuvant docetaxel and capecitabine for breast cancer. Breast Cancer Res Treat. 2010 Feb;119(3):685-99.

Fuhrman BJ, Pfeiffer R, Xu X, Wu AH, Korde L, Gail MH, Keefer LK, Veenstra TD, Hoover RN, Ziegler RG. Soy intake is associated with increased 2-hydroxylation and decreased 16alpha-hydroxylation of estrogens in Asian-American women. Cancer Epidemiol Biomarkers Prev. 2009 Oct;18(10):2751-60. Epub 2009 Sep 29. Erratum in: Cancer Epidemiol Biomarkers Prev. 2009 Nov;18(11):3138.

Giambartolomei C, Mueller CM, Greene MH, Korde LA. A mini-review of familial ovarian germ cell tumors: an additional manifestation of the familial testicular germ cell tumor syndrome. Cancer Epidemiol. 2009 Jul;33(1):31-6. Epub 2009 May 30. Review.

Korde LA, Gadalla SM. Cancer risk assessment for the primary care physician. Prim Care. 2009 Sep;36(3):471-88.

Mai PL, Chen BE, Tucker K, Friedlander M, Phillips KA, Hogg D, Jewett MA, Bodrogi I, Geczi L, Olah E, Heimdal K, Fosså SD, Nathanson KL, Korde L, Easton DF, Dudakia D, Huddart R, Stratton MR, Bishop DT, Rapley EA, Greene MH. Younger age-atdiagnosis for familial malignant testicular germ cell tumor. Fam Cancer. 2009;8(4):451- 6. Epub 2009 Jul 17.

Horvath A, Korde L, Greene MH, Libe R, Osorio P, Faucz FR, Raffin-Sanson ML, Tsang KM, Drori-Herishanu L, Patronas Y, Remmers EF, Nikita ME, Moran J, Greene J, Nesterova M, Merino M, Bertherat J, Stratakis CA. Functional phosphodiesterase 11A mutations may modify the risk of familial and bilateral testicular germ cell tumors. Cancer Res. 2009 Jul 1;69(13):5301-6. Epub 2009 Jun 23.

Vadaparampil ST, Moser RP, Loud J, Peters JA, Greene MH, Korde L. Factors associated with testicular self-examination among unaffected men from multiple-case testicular cancer families. Hered Cancer Clin Pract. 2009 May 29;7(1):11.

Korde LA, Micheli A, Smith AW, Venzon D, Prindiville SA, Drinkard B, Sebring N, Smith MD, Zujewski JA, Eng-Wong J. Recruitment to a physical activity intervention study in women at increased risk of breast cancer. BMC Med Res Methodol. 2009 Apr 27;9:27.

Korde LA, Wu AH, Fears T, Nomura AM, West DW, Kolonel LN, Pike MC, Hoover RN, Ziegler RG. Childhood soy intake and breast cancer risk in Asian American women. Cancer Epidemiol Biomarkers Prev. 2009 Apr;18(4):1050-9. Epub 2009 Mar 24.

Cook MB, Sigurdson AJ, Jones IM, Thomas CB, Graubard BI, Korde L, Greene MH, McGlynn KA. Endogenous DNA damage and testicular germ cell tumors. Int J Androl. 2009 Dec;32(6):599-606. Epub 2008 Jul 24.

Korde LA, Premkumar A, Mueller C, Rosenberg P, Soho C, Bratslavsky G, Greene MH. Increased prevalence of testicular microlithiasis in men with familial testicular cancer and their relatives. Br J Cancer. 2008 Nov 18;99(10):1748-53. Epub 2008 Oct 7.

Linger R, Dudakia D, Huddart R, Tucker K, Friedlander M, Phillips KA, Hogg D, Jewett MA, Lohynska R, Daugaard G, Richard S, Chompret A, Stoppa-Lyonnet D, Bonaïti- Pellié C, Heidenreich A, Albers P, Olah E, Geczi L, Bodrogi I, Daly PA, Guilford P, Fosså SD, Heimdal K, Tjulandin SA, Liubchenko L, Stoll H, Weber W, Einhorn L, McMaster M, Korde L, Greene MH, Nathanson KL, Cortessis V, Easton DF, Bishop DT, Stratton MR, Rapley EA. Analysis of the DND1 gene in men with sporadic and familial testicular germ cell tumors. Genes Chromosomes Cancer. 2008 Mar;47(3):247-52.

Mueller CM, Korde L, Katki HA, Rosenberg PS, Peters JA, Greene MH. Constitutional cytogenetic analysis in men with hereditary testicular germ cell tumor: no evidence of disease-related abnormalities. Cancer Epidemiol Biomarkers Prev. 2007 Dec;16(12):2791-4. No abstract available.

Mai PL, Korde L, Kramer J, Peters J, Mueller CM, Pfeiffer S, Stratakis CA, Pinto PA, Bratslavsky G, Merino M, Choyke P, Linehan WM, Greene MH. A possible new syndrome with growth-hormone secreting pituitary adenoma, colonic polyposis, lipomatosis, lentigines and renal carcinoma in association with familial testicular germ cell malignancy: A case report. J Med Case Reports. 2007 Mar 28;1:9.

Korde LA, Calzone KA, Zujewski J. Assessing breast cancer risk: genetic factors are not the whole story. Postgrad Med. 2004 Oct;116(4):6-8, 11-4, 19-20.

Last updated: May 2011

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