Gary H. Lyman, MD, MPH

Gary H. Lyman, MD, MPH, FASCO, FRCP (Edin)

Co-Director, Hutchinson Institute for Cancer Outcomes Research (HICOR)
Public Health Sciences and Clinical Research Divisions
Fred Hutchinson Cancer Research Center
Professor of Medicine/Medical Oncology, University of Washington School of Medicine

Mailing Address

Seattle Cancer Care Alliance
825 Eastlake Ave W
Seattle, WA 98109-1023

Admin Contact

Andrea Tate
Fax: 206.667.5977

Specialty / Expertise

  • Practicing medical oncologist
  • Member, Public Health Sciences Division, Fred Hutchinson Cancer Research Center
  • Member, Clinical Research Division, Fred Hutchinson Cancer Research Center

Research Interests

  • Comparative effectiveness and outcomes research; health economics; clinical prediction risk modeling.

Current Research Projects

  • Personalized cancer supportive care through risk stratification and targeted intervention;
  • Systematic evidence summaries of several clinical practice topics in support of ASCO clinical practice guidelines;
  • Defining and measuring the value of cancer care using multi-stakeholder engagement (HICOR)


Dr Lyman received his BA and MD through the State University of New York at Buffalo and an MPH in Biostatistics at the Harvard School of Public Health. He completed his Internal Medicine Residency at the University of North Carolina in Chapel Hill and his Fellowships in Hematology and Medical Oncology at the Roswell Park Memorial Institute as well as a postdoctoral fellowship at the Dana Farber Cancer Center in Boston.

Selected Publications

Hirsch B, Reed SD, Lyman GH: Update on the Role of Epothilones in Metastatic Breast Cancer. Current Breast Cancer Reports 2013; 5: 51-56.

Reed SD, Dinan MA, Schulman KA, Lyman GH: Cost-Effectiveness of the 21-Gene Recurrence Score Assay in the Context of Multifactorial Decision Making to Guide Chemotherapy for Early-Stage Breast Cancer. Genetics in Medicine 2013; 15: 203-211

Nguyen XV, Choudhury KR, Eastwood JD, Lyman GH, Esclamado RM, Werner JD, and Hoang JK: Incidental Thyroid Nodules on CT: Comparison of Two Risk Categorization Methods for Workup of Nodules, American Journal of Neuroradiology, 2013; 34: 1812-1817.

Hanna RK, Poniewierski MS, Laskey RA, Lopez MA, Shafer A, Van Le L, Crawford J, Dale, DC , Gehrig PA, Secord AA, Havrilesky LJ, Lyman GH: Predictors of reduced relative dose intensity and its relationship to mortality in women receiving multiagent chemotherapy for epithelial ovarian cancer  Gynecologic Oncology 2013; 129: 74-80.

Lyman GH, Baker J, Geradts J, Horton J, Kimmick G, Peppercorn J, Pruitt S, Scheri R, Hwang ES: Multidisciplinary Care of Patients with Early-Stage Breast Cancer. Surg Oncol Clin N Am 2013; 22: 299-317.

Simonds NI , Khoury MJ, Schully SD, Armstrong K, Cohn W, Fenstermacher  D, Ginsburg GS , Goddard KAB, Knaus W , Lyman GH, Ramsey SD, Xu J , Freedman AN. Comparative Effectiveness Research in Cancer Genomics and Precision Medicine: Current Landscape and Future Prospects. J Natl Cancer Inst 2013; 105: 929-936

Lyman GH, Khorana A, Kuderer NM, et al: Venous Thromboembolism Prophylaxis and Treatment in Patients with Cancer: American Society of Clinical Oncology Clinical Practice Guideline Update. J Clin Oncol 2013; 31: 2189-2204.

Lyman GH: Comparative Effectiveness Research in Oncology. The Oncologist 2013 18: 752-759.

Lyman GH, Sparrenboom A: Chemotherapy dosing in Overweight and Obese Paitents with Cancer. Nature Reviews Clinical Oncology. 2013; 10: 451-459.

Lyman GH, Dale DC, Tomita D, Whittaker S, Crawford J: A Retrospective Evaluation of Chemotherapy Dose Intensity and Supportive Care in Early-Stage Breast Cancer. Br Cancer Res Treat 2013;139: 863-872.

Shayne M, Culakova E, Poniewierski M, Dale DC, Crawford J, Wogu AF, Lyman GH: Risk Factors for In-Hospital Mortality and Prolonged Length of Stay in Older Patients with Solid Tumor Malignancies. J Geriatric Oncology 2013; 4: 310-318.

Walenga J, Lyman GH: Evolution of Heparin Anticoagulants to Ultra-Low-Molecular-Weight Heparins: a Review of Pharmacologic and Clinical Differences and Applications in Patients with Cancer. Crit Rev Oncol Hematol 2013; 88: 1-18.

Lyman GH, Dale DC, Culakova E, Poniwierski MS, Wolff DA, Kuderer NM, Huang M, Crawford J: The Impact of Granulocyte Colony-Stimulating Factor on Chemotherapy Dose Intensity and Cancer Survival: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Ann Oncol 2013; 24: 2475-2484.

Zhang T, Schneider A, Hamilton EP, Patel K, Kamal AH, Lyman GH, Peppercorn J: Prevalence and impact of correlative science in breast cancer phase II trials. Br Cancer Res Treat 2013;139: 845-850.

Peppercorn J, Hamilton E, Marcom PK, Beskow L, Lyman GH: Pharmacogenetic Testing in the Face of Unclear Clinical Efficacy: Lessons from CYP2D6 for Tamoxifen. Cancer 2013; 119: 3703-3709.

Lyman GH, Eckert L, Wang Y, Wang H, Cohen A: Venous Thromboembolism Risk in Patients with Cancer Receiving Chemotherapy: A Real-World Analysis. The Oncologist 2013; 18: 1321-1329.

Hirsch B and Lyman GH: Will Biosimilars Gain Momentum? J Natl Comp Cancer Netwk 2013; 11: 1291-1297.

Schnipper L, Lyman GH, Blayney DW, Hoverman R, Raghavan D, Wollins DS, Schilsky RL: The ASCO 2013 Top Five List in Oncology. J Clin Oncol 2013; 31: 4362-4370.

Lyman GH: Counting the Costs and Value of Cancer Care. Lancet Oncol 2013; 14: 1142-1143.

Hoang J, Lyman GH:  An Exponential Growth in Thyroid Cancer: Trends in Incidence and Impact of CT Imaging. Am J Nuc Rad 2014; 35: 778-783.

Lyman GH, Benson AB, Bosserman L, Burstein HJ, Cody HS, Edge SB, Hayman JA, Newman LA, Perkins CL, Podoloff DA, Turner RR, Weaver DL, Giuliano AE: Sentinel Lymph Node Biopsy for Patients with Early-Stage Breast Cancer: American Society of Clinical Oncology Clinical Practice Guideline Update, J Clin Oncol 2014 (epub March 24, 2014).

Bower J, Bak K, Berge A, Breitbart W, Escalante C, Ganz PA, Schnipper HH, Ligibel JA, Lyman GH, Ogaily M, Pirl WF, Jacobsen P: American Society of Clinical Oncology guideline regarding screening, assessment and management of fatigue in adult cancer survivors.  J Clin Oncol 2014 (epub ahead of print April 14 2014).

Culakova E, Thota R, Poniewierski MS, Kuderer NM, Wogu AF, Dale DC, Crawford J Lyman GH: Patterns of Chemotherapy-Associated Toxicity and Supportive Care in US Oncology Practice: A Nationwide Prospective Cohort Study. Cancer Medicine 2014; 3: 434-444.

Buchholz TA, Somerfield MR, Griggs JJ, El-Eid S, Hammond EH, Lyman GH, Mason G, Newman L: Margins for Breast-Conserving Surgery with Whole Breast Irradiation in Stage I and II Invasive Breast Cancer: American Society of Clinical Oncology Endorsement of the SSO-ASTRO Consensus Guideline. J Clin Oncol 2014 (epub April 7 2014).

Brücher B, Lyman GH, Nissan A et al: Imagine a World Without Cancer. BMC Cancer 2014 (epub March 14, 2014).


Last updated: April 2014