Orthopaedic Science Laboratories
 
 
Research Interests My research interests are in the broad areas of hard tissue and cellular physiology, mechanotransduction, and in developing exercise based and tissue-engineered solutions to bone loss pathologies. In our research, we utilize a number of technologies from animal and cell culture models, imaging, histomorphometry, immunohistochemistry and gene expression profiling along with complex, multi-scale computational models. My current focus area involves the exploration of bone mechanotransduction using agent based modeling techniques developed for the analysis of general classes of complex adaptive systems. These studies have long term potential towards providing unique insights into how networked cells within the bone syncytium perceive and respond to mechanical stimuli and are expected to lead to the development of computational frameworks for the design of potent exercise strategies to augment bone mass and strength in humans.  Current Academic Appointments Adjunct Research Associate Professor Department of Mechanical Engineering, University of Washington (2007 to Present) Research Associate Professor Department of Orthopaedics and Sports Medicine, University of Washington (2007 to Present)  Honors Journal of Biomechanics Award, American Society of Biomechanics (2001) Scholoraship, Sigma XI, The Scientific Research Society (1994)  Recent Publications S.L. Poliachik, D. Threet, S. Srinivasan, T.S. Gross, “32 wk Old C3H/HeJ Mice Actively Respond to Mechanical Loading,” Bone, 42, 653 – 659, 2008. S. Srinivasan, B.J. Ausk, S.L. Poliachik, S.E. Warner, T.S. Gross, “Rest-Inserted Loading Rapidly Amplifies the Response of Bone to Small Increases in Strain and Load Cycle,” Journal of Applied Physiology, 102, 1945-1952, 2007. B.J. Ausk, T.S. Gross, S. Srinivasan, “An Agent Based Model for Real-Time Signaling Induced in Osteocytic Networks by Mechanical Stimuli,” Journal of Biomechanics, 39, 2638-2646, 2006. K. Hankenson, P. Bornstein, S.D. Bain, T.S. Gross, S. Srinivasan, “Mice lacking thrombospondin-2 show an atypical pattern of endocortical and periosteal bone formation in response to mechanical loading”, Bone, 38, 310-316, 2006. T.S. Gross, K.A. King, N.A. Rabaia, P. Pathare, S. Srinivasan, “Upregulation of Osteopontin by Osteocytes Deprived of Mechanical Loading or Oxygen,” Journal of Bone Mineral Research, 20, 250-256, 2005. T.S. Gross, S.L. Poliachik, B.J. Ausk, D.A. Sanford, B. A. Becker, S. Srinivasan, “Why Rest Stimulates Bone Formation: A Hypothesis Based upon Complex Adaptive Phenomenon”, Exercise and Sports Sciences Reviews, 32, 9-13, 2004. 
Related Links
  1. •  UW Department of Mechanical Engineering
 
  1.  Curriculum Vitae
Education
  1. •Post-Doc Univ. of Cincinnati - Bone Physiology (1999)
  2. •Ph.D. Clemson University - Bioengineering (1996)
  3. •M.S. Clemson University - Engineering Mechanics (1992)
  4. •B.S. Birla Institute of Tech. and Science, India - Mechanical Engineering (1989)
 
contact
sundars@u.washington.edu
P: 206.897.5606
F: 206.897.5611
 
Sundar Srinivasan, Ph.D.