Research Interests
My research interests are in the broad areas of hard tissue and cellular physiology, mechanotransduction, and in developing exercise based and tissue-engineered solutions to bone loss pathologies. In our research, we utilize a number of technologies from animal and cell culture models, imaging, histomorphometry, immunohistochemistry and gene expression profiling along with complex, multi-scale computational models. My current focus area involves the exploration of bone mechanotransduction using agent based modeling techniques developed for the analysis of general classes of complex adaptive systems. These studies have long term potential towards providing unique insights into how networked cells within the bone syncytium perceive and respond to mechanical stimuli and are expected to lead to the development of computational frameworks for the design of potent exercise strategies to augment bone mass and strength in humans.
Education
| 1999 | Post-Doc | Bone Physiology | University of Cincinnati |
| 1996 | Ph.D. | Bioengineering | Clemson University |
| 1992 | M.S. | Engineering Mechanics | Clemson University |
| 1989 | B.E. | Mechanical Engineering | Birla Institute of Technology and Science, India |
Academic Appointments
| 2003-pres |
Adjunct Research Assistant Professor, Department of Mechanical Engineering, University of Washington |
| 2000-pres |
Research Assistant Professor, Department of Orthopaedics and Sports Medicine, University of Washington |
| 2000 |
Research Assistant Professor, Department of Orthopaedic Surgery, University of Cincinnati |
| 1997-99 |
Post-Doctoral Fellow, Department of Orthopaedic Surgery, University of Cincinnati |
Honors
| 2001 | Journal of Biomechanics Award, American Society of Biomechanics |
| 1994 | Scholarship, Sigma XI, The Scientific Research Society |
Select Publications
Ausk, B.J, Gross, T.S., Srinivasan, S. (in press). An Agent Based Model for Real-Time Signaling Induced in Osteocytic Networks by Mechanical Stimuli, J Biomechanics
Hankenson, K.D., Ausk, B.J., Bain, S.D., Bornstein, P., Gross, T.S., Srinivasan, S. (2006). Mice lacking thrombospondin-2 show an atypical pattern of endocortical and periosteal bone formation in response to mechanical loading. Bone, 38, 310-316.
Gross, T.S., Poliachik, S.L., Ausk, B.J., Sanford, D.A., Becker, B.A., Srinivasan, S. (2004). Why Rest Stimulates Bone Formation: A Hypothesis Based Upon Complex Adaptive Phenomenon, ESSR, 32:9-13.
Srinivasan, S., Weimer, D.A., Agans, S.C., Bain, S.D., Gross, T.S. (2002). Low magnitude mechanical loading becomes osteogenic when rest is inserted between each load cycle. J Bone Min Res, 17:1613-1620.
Gross, T.S., Srinivasan, S., Liu, C.C., Clemens, T.L., and Bain, S.D. (2002). Non-invasive loading of the murine tibia: An in vivo model for study of mechanotransduction. J Bone Min Res, 17:493-501.
Srinivasan, S., Gross, T.S. (2000). Canalicular Fluid Flow Induced by Bending of a Long Bone. Med Eng Phys, 22, 127-133.
Srinivasan, S., de Andrade, J.R., Biggers Jr, S.B., Latour Jr., R.A. (1999). 3-D Global/Local Analysis of Composite Hip Prostheses- A Model for Multiscale Structural Analysis. Compos Struct, 45, 163-170.
Srinivasan, S., Biggers Jr, S.B., Latour Jr., R.A. (1996). Identifying Global/Local Interface Boundaries using an Objective Search Method. Int J Numer Methods Eng, 39, 805-828.