The Orthopaedic Science Laboratories broadly examines how bone responds to physical stimuli, both small and large. We use multi-disciplinary approaches to examine basic cellular signaling pathways at levels ranging from expression of specific transcription factors in response to mechanical loading (or lack thereof) to use of complex adaptive systems biology to study the integrated behavior of osteocyte/osteoblast networks.
Lab Outing at StoneGardens Climbing Center, October 2005.
Upcoming OSL Presentations:
2008 Orthopaedic Research Society Annual Meeting (March 2-5), San Francisco, CA.
Electrical Muscle Stimulation Induces Insufficient Strain to Mitigate Bone Loss
Induced by Muscle Paralysis-Poster
Deficits in the Ca2+/NFAT
Pathway may Account for Age-Related
Degradation in Bone Mechanotransduction-Poster
Muscle Function is Critical for
Successful Fracture Healing-Poster