Thiazide DiureticsHayley Miller, MD & Heidi Powell, MD Literature reviewed September 01, 2008
Click an answer under each question.
Which antihypertensive agents have been shown in randomized controlled trials to increase bone density?
What is the mechanism by which thiazide diuretics affect bone mineral density?
How does thiazide use impact fracture risk?
- Option A The few randomized controlled trials that have been done show a 10% or less decrease in fracture risk
- Option B There is no evidence that it affects fracture risk based on observational studies
- Option C Observational studies show that it decreases fracture risk, but randomized controlled trials have not been done
- Option D It increases fracture risk slightly, despite increasing BMD
She wants to know if there are any side effects from hydrochlorothiazide. You tell her that the medication is generally very well tolerated but it can have side effects. Which of the following are side effects of hydrochlorothiazide?
The astute medical student assisting with the case inquires whether HCTZ is FDA approved for treatment of osteoporosis. You tell her: