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Oesterle Laboratory

Research Associate Professor

Otolaryngology - Head and Neck Surgery

Research Affiliations
Virginia Merrill Bloedel Hearing Research Center
Center on Human Development and Disability


Areas of Expertise
Hair cell Regeneration
Inner Ear Anatomy and Physiology

Graduate Education
MS, PhD--Purdue University, W. Lafayette, IN

Postgraduate Education
Postdoctoral Fellow, University of Washington, Seattle, WA, 1987-1992

Primary Research Support
Principal Investigator, NIH/NIDCD R01, Hair Cell Regeneration: Regulatory Signals

Special Honors, Academic and Non-Academic(s)
Member, Alpha Lambda Delta
Member, Sigma Pi Sigma
Member, Phi Kappa Phi
Markey Fellow, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, 1986
F.V. Hunt Fellowship in Acoustics, 1988-1989

Ad hoc reviewer for Auditory Neuroscience, Brain Research, Hearing Research, Histology and Histopathology, Journal of the Association for Research in Otolaryngology, Journal of Comparative Neurology, Journal of Neurobiology, Journal of Neurocytology, Journal of Neuroscience.

Member, American Association for the Advancement of Science
Member, Association for Research in Otolaryngology
Member, Society for Neuroscience

Most Significant Recent Articles

Research Activities:

Hair cell regeneration: Regulatory Signals: The goal of the proposed research is to identify factors that regulate regenerative replacement of hair cells in the ears of warm-blooded vertebrates during postembryonic life. This project investigates the following hypotheses: 1) Endogenous growth factors may negatively regulate inner-ear stem/progenitor cell proliferation, and 2) Robust regenerative proliferation of stem/progenitor cells in mature inner-ear SE may require a simultaneous release from negative regulation coupled with mitogenic signaling by the EGF and/or IGF pathways. This work is funded by an NIH R01.

Hearing Regeneration Initiative: Studies whose overall goal is to find the cellular and molecular factors capable of inducing and controlling sensory cell regeneration in the human inner ear. Over 6 collaborative research teams are working together to reach this objective. This work is funded by private foundations and individuals.

Invited Lectures:

  • Culture methods for organs, cells, and slices. NIDCD/CHDD sponsored Live Cell Imaging Course, 2005
  • Hair cell Regeneration, Hearthstone, Seattle, 2005
  • Hair cells: Gone Today, HEAR Tomorrow, Tacoma, 2005
  • Hair cell Regeneration, Ears Hearing and Beyond, Seattle WA, 2002
  • Growth factor regulation of the cell cycle in inner ear sensory epithelia, Cell Cycle Analyses: Auditory Receptor Development and Regeneration Symposium, ARO MidWinter Meeting, FL

Practice Priorities
On research: "I work with talented undergraduate and graduate students, medical students, residents, postdoctoral fellows, professional staff, and faculty members on a wide variety of challenging, intriguing, and interesting research questions. It's often loads of fun and a great way to earn a living!"

On teaching: "Classroom lectures and one-on-one instruction are great learning opportunities for both students and teacher."

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