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JAMES O. PHILLIPS, PHD
Phillips Laboratory
Research Associate Professor
Department(s)
Otolaryngology - Head and Neck Surgery
Research Affiliations
Human Interface Technology Laboratory
University of Washington Autism Center
Virginia Merrill Bloedel Hearing Research Center (VMBHRC)
Washington National Primate Research Center
Specialties
Physiology, Psychology
Clinics, Maps and Directions
University of Washington Medical Center (UWMC)
Children's Hospital and Regional Medical Center (CHRMC)
Area(s) of Expertise
Motor Development
Oculomotor Neurophysiology
Vestibular Neurophysiology
Visual Development
Graduate Education
Ph.D.-- Psychology and Physiology, University of Washington, Seattle, WA, 1993
Postgraduate Education
Post-doctoral Fellowship, Neurophysiology, University of Washington, Seattle, WA, 1993-1997
Local and National Leadership Positions
Director, Dizziness and Balance Center, Otolaryngology - Head and Neck Surgery Clinic, UWMC
Director, Clinical Oculomotor Laboratory, Division of Ophthalmology, CHRMC
Member, Virginia Merrill Bloedel Affiliate Liason Committee
Primary Research Support
Principal Investigator, NASA NNA04CC60G, Gravitational Influence on Cerebellar Control of Gaze Movement and Adaptation
Principal Investigator, NIH N01-DC-6-005, Neurophysiological Studies of Electrical Stimulation for the Vestibular Nerve
Co-Principal Investigator with Sara Webb, NAAR, Linking Cerebellar Pathology to Functioning in Individuals with Autism: Implications for Translational Research
Co-Principal Investigator with Chris Kaneko, NIH 1 R21 DC008085-01A1, Vestibular and optokinetic testing for research and clinic.
Special Honors, Academic and Non-Academic(s)
Ad-hoc Reviewer: Archives of Pediatrics and Adolescent Medicine, Experimental Brain Research, Ear and Hearing, Journal of Cognitive Neuroscience, Journal of Neurophysiology, Journal of Vestibular Research, Neurobiology of Aging, Neuroscience Letters, Investigative Ophthalmology and Visual Science
Member: Society for Neuroscience, Association for Research in Vision and Ophthalmology, Barany Society, Society for the Neural Control of Movement, International Brain Research Organization
Most Significant Recent Articles
Research Activities:
Eye abnormalities in Joubert Syndrome and Related Disorders
A study of 8 pediatric patients with Joubert syndrome suggests that there are profound oculomotor disorders in this patient population. Weiss, AH, Parisi, M., Doherty, D., Shaw, D., and Phillips, J.O. Invest. Ophthalmol. Vis. Sci., 45: 2324, 2004
Oculomotor Findings in Posterior Fossa Tumors
A study of 35 pediatric patients with neoplasms of the brainstem and cerebellum concludes that there are significant post-surgical changes in eye movement and balance function. Phillips, J.O., Shaw, D.W., Ellenbogen, R.G., Weiss, A.H., Invest. Ophthalmol. Vis. Sci. 45: 2529, 2004
Role of vestibular testing in a pediatric ophthalmology practice
A study of 135 pediatric patents demonstrates the utility of formal vestibular testing in the diagnosis and treatment of motor incoordination in children. Weiss, AH and Phillips, J.O. AAPOS, 105p, 2004
Discharge of brainstem burst neurons during combined eye and head gaze shifts in canal-plugged monkeys
A study in rhesus monkeys demonstrates changes in brainstem burst neuron activity during natural orienting behavior following loss of vestibular input. Phillips, J.O., Fuchs, A.F, Ling, L. Barany XXIII, 2004
Effects of bilateral canal plugging on the discharge of brainstem neurons during eye and head gaze shifts
A study in rhesus monkeys demonstrates that changes in brainstem omnipause and burst tonic neuron activity during natural orienting behavior can be modeled as a linear system with vestibular inputs at multiple levels. Phillips, J.O , Ling, L., Fuchs, A.F. Barany XXIII, 2004
Influence of tilt on normal and adapted saccades in monkey
A study in rhesus monkeys concludes that the ocular tilt reaction has a significant influence on vertical conjugacy, but not on the metrics of saccades or on saccadic adaptation. Phillips, J.O., Noto, C., Robinson, F.R. Society for Neuroscience, 990.10, 2004
Analysis and treatment of hypertropia in plagiocephaly
A study in 11 pediatric patients demonstrates that the dysconjugacy seen in plagiocephaly is successfully modeled as a dislocation of muscle pulleys, leading to a new surgical approach. Weiss, A.H., Sze, R., Phillips, J.O. Invest. Ophthalmol. Vis. Sci. 2005, 46: 2352
Context Dependence of Human and Nonhuman Primate Saccade Adaptation
A study in rhesus monkeys and humans demonstrates that roll tilt context but not pitch tilt context provides a salient cue for context dependent adaptation, and that adaptation transfers from the laboratory environment to natural movements. Phillips, J.O., Noto, C., Ibarreta, M., Robinson, F.R. Society for Neuroscience, 859.7, 2005
Eye movements in craniosynostosis
A study in 8 children with Crouzon's syndrome demonstrates that changes in conjugate gaze and dynamic eye movements are the consequence of cyclorotation of the eye muscles and Herring's Law of equal innervation. Weiss, A.W., Phillips, J.O. Invest. Ophthalmol. Vis. Sci. 2006
Invited Lectures:
- Phillips, J.O. Laboratory Vestibular Testing Advanced Temporal Bone Lab 2005, Seattle, WA, 2005
- Vestibular and Oculomotor Function in Pediatric Patients with Posterior Fossa Tumors, Oto-HNS Alumni Day 2005
- Phillips, J.O. Disequilibrium and the Ear; I'm not dizzy, I just fall down. Ears Hearing and Beyond, Seattle, WA, 2006
- Eye Movement Disorders in Craniosynostosis, Craniofacial Conference, Children's Hospital and Regional Medical Center, 2006
Practice Priorities
On Research: "I really enjoy taking ideas from the basic science laboratory into the clinic. Much of what I do involves translation of scientific theory into practical tools for assessment of patients. At the University, I can study genetics of vestibular function in mice, basic physiological mechanisms in non-human primates, the development of behavior in infants and children, and the behavioral consequences of disease and developmental disorders in patients. I get to work with bright and talented undergraduates, graduate students and faculty colleagues on a wide range of really interesting stuff. It is pretty cool."
On Teaching: "I like to discuss things with people. I gain insights when I do that. Teaching, whether in a large undergraduate survey course or a small seminar, is just an extension of that. It is an extended opportunity to share ideas with others."
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