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Stone Laboratory

Research Associate Professor

Otolaryngology - Head and Neck Surgery

Research Affiliations
Virginia Merrill Bloedel Hearing Research Center
Center on Human Development and Disability

Areas of Expertise
Inner Ear Development and Cell Biology
Hair Cell Regeneration
Confocal Microscopy
Cell and Tissue Culture
Anatomical and Histological Methods

Graduate Education
PhD--Anatomy and Neurobiology, Boston University School of Medicine, 1993

Postgraduate Education
Postdoctoral Fellow, Otolaryngology-Head and Neck Surgery, University of Washington, Seattle, WA, 1998

Local and National Leadership Positions
Member, Ad Hoc Publications Committee, Association for Research in Otolaryngology, 1998-1999.
Member, Travel Award Committee, Association for Research in Otolaryngology, 2001-2006.
Ad Hoc Reviewer, IFCN6 Study Section, NIH/NIDCD, 2002-2003.
Ad Hoc Reviewer, Development, Journal of Comparative Neurology, J. Neurobiology, Hearing Research, J. Assoc. Research in Otolaryngology.
Member, Review Committee, CDRC Study Section, NIH/NIDCD, four year appointment, 2005-present.
Director/Co-Director, NIDCD/NIH-supported P30 Core for Communications. Member, Research/Microscopic Imaging Subunit, University of Washington, 2000-present.
Member, Resident Admissions Committee, Otolaryngology-Head and Neck Surgery, University of Washington, 2004-present.

Primary Research Support
Principal Investigator, “Hair cell regeneration: Molecular regulation”, NIH/NIDCD R01 Award, April, 2007-March, 2012.

Core Director, “Core for Communications Research”, NIH/NIDCD P30 Core Grant
PI: Edwin Rubel, September 2000-2010.

Mentor, American Otological Society Fellowship "The role of transdifferentiation in the recovery of auditory function". PI: Dr. Vincent Lin, Jun/06-Jun/08.

Training Faculty, Auditory Neuroscience Training Grant, NIH/NIDCD T32 Grant, PI: Ellen Covey, July 2002-present.

Training Faculty, Resident Research, Basic Science Training/Otolaryngology, NIH/NIDCD T32 Grant, PI: Ernest Weymuller, July 2003-May 2008.

Co-Principal Investigator, NIH/NCRR Shared Equipment Grant to provide microscope for P30 Core Facility.

Principal Investigator, “Morphological analysis of hair cell regeneration involving direct transdifferentiation only, in the chicken auditory epithelium.” Bloedel Center Minigrant, January 2006-December 2006.

Special Honors, Academic and Non-Academic(s)
Member, Periclean Honor Society, Skidmore College, 1984 and 1985
Dowd-Lester Award, Outstanding Student in Biology, Skidmore College, 1985
Honors, Department of Biology, Skidmore College, 1985
First Award, Recognition of Dissertation Research for 1993, Boston University
Burt Evans Award, Outstanding Young Investigator, National Organization for Hearing Research, February 2001
Dorrance H. Hamilton Award, Auditory Science, National Organization for Hearing Research, 2003

Most Significant Recent Articles

Research Activities
Dr. Jennifer Stone studies the genes and signaling pathways important for hair cell regeneration in mature chickens, with the hope that future comparative studies with mammals will yield promising strategies for triggering the production of new hair cells in mammals, including humans. Her current studies aim to unveil cellular and molecular mechanisms governing the behavior of progenitor-like supporting cells after hair cell damage. She uses proteomic and genomic surveys to identify genes that are dynamically expressed after hair cell damage. She examines temporal and spatial expression of such proteins and genes to determine if they are likely candidates for regulating critical phases of hair cell regeneration. And, she performs functional studies, in vivo and in vitro, to test the role of candidate genes in different cellular processes associated with hair cell regeneration, including supporting cell division and direct transdifferentiation.

Invited Lectures

  • National Academy of Sciences Colloquium on Auditory Neuroscience, Irvine, CA, May 19, 2000.
  • Symposium on Stem Cell Research, Association for Research in Otolaryngology Midwinter Meeting, Daytona Beach, FL, February 23, 2003.
  • Symposium: Restoring Damaged Inner Ear Hair Cells and Their Neural Connections, American Association for the Advancement of Science, Washington, D.C., February 18, 2005.

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