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Tempel Laboratory

Professor, Director of Research
Otolaryngology - Head and Neck Surgery

Pharmacology - The V.M. Bloedel Hearing Research Center

Otolaryngology - Head and Neck Surgery

Research Affiliations
Virginia Merrill Bloedel Hearing Research Center

Research Interests
Neurogenetics of Auditory Function
Genetics of Hearing Loss
Auditory Signal Encoding

Future Research Interests
One future focus is on identifying the genes that contribute to noise resistance. We have completed a quantitative trait locus (QTL) map that shows three chromosomes with significant LOD score peaks. We are currently evaluating candidate genes using expression profiling on arrays, ancestral SNP analysis and direct sequence comparisons between resistant and non-resistant strains.

A second focus is on the role of Atp2b2, the deafwaddler gene, as a modifier gene that interacts with other hearing loss loci in both mice and humans. We are also studying the role of Atp2b2 in age-related hearing loss (ARHL) as well as in noise-induced hearing loss (NIHL) using an allelic series of mutants to give varying dosages of gene function.

Graduate Education
BS--Pacific Lutheran University, Seattle, WA, 1978
MA--Princeton University, Princeton, NJ, 1980
PhD--Princeton University, Princeton, NJ, 1983

Local and National Leadership Positions
Member, American Association for the Advancement of Science
Member, Association for Research in Otolaryngology
Member, International Mammalian Genome Society
Member, Society for Neuroscience

Funding Received
National Institutes of Health (NIH): Genetics of Noise Resistance, $250,000 direct cost, 2001 to 2008.
National Institutes of Health (NIH): U.W. Core for Communication Research, $100,000 direct cost, 2000 to 2010.
National Institutes of Health (NIH): Auditory Neurogenetics, $250,000 direct cost, 1995 to 2007.

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