The Division of Otolaryngology is in the Department of Surgery at Children's Hospital and Regional Medical Center (CHRMC).
The Division of Pediatric Otolaryngology has clinical, translational and basic research programs. Clinical research efforts are focused on outcomes with speech surgery, epidemiology of cochlear implantation, novel measures of hearing in pediatric cochlear implant patients, management of pediatric airway compromise and other otolaryngologic problems common to the pediatric population. Collaborative efforts to study the molecular biology of vascular malformations are underway. The basic research efforts are focused on ototoxicity and otoprotection. For a description of current research directions in the Division please go here.
Several intramural laboratories are pursuing active research within the Children's Hospital. A list of our faculty and links to their activities are presented below:
The Audiology Research Laboratory was constructed on the main campus of Children's Hospital in 1991 for Dr. Susan Norton, who is the Director of Research and Clinical Audiology. It is approximately 1,000 square feet and contains two RF shielded double-walled IAC sound rooms used for psychophysical, acoustic and electrophysiological experiments related to hearing in human infants, children and young adults.
The laboratory consists of a control room where computers and other equipment controlling experiments in either or both booths are housed, office space for a research assistant and programmer, a central work-meeting area and an electronics and computer shop.
Auditory Electrophysiology Laboratory:
The second auditory electrophysiology laboratory is fully equipped for small animal surgery and studies using evoked potentials or otoacoustic emissions. Major equipment includes two HP 3561A Spectrum analyzers, an HP 3326A function generator, an RC-Electronics Data Acquisition system, an Otodynamics IL092 Otoacoustic Emissions system, an Ariel DSP board, various TTES digital attenuators, switches, Quikki D/A and A/D and noise generators, Crown amplifiers, Kemo digital filters, and two Itaco Lock-in amplifiers.
The laboratories also have an Etymotic Research ER 10 and an ER 10B microphone system for measuring otoacoustic emissions in addition to various drivers used for signal delivery (i.e., ER-2, ER-3A, ER-1, B&K 4144 microphones reverse driven). A B&K 4134 microphone plus power supply with a DB-100 coupler as well as a Quest Model 1700 sound level meter with a Model OB-300 third and one-octave filter set are used in stimulus calibration.
Clinical equipment includes a Biologic Navigator ABR system, an Intelligent Hearing Systems Smart EP system, an Otodynamics IL092, Grason-Stadler 33 Version II. 1723 and 28A emittence devices, three portable audiometers, a GSI-16 and a GSI-10 diagnostic audiometer.
Clinical Oculomotor Laboratory:
The Clinical Oculomotor Laboratory was created as a collaboration between Dr. James Phillips in the Department of Otolaryngology and Dr. Avery Weiss, Chief of the Division of Ophthalmology in the Department of Surgery at Children's Hospital. It is located on the Children's main campus in the Vision Clinic in the Ambulatory Care Building, and is directed by Dr. Phillips.
The Laboratory resides in a 300 square foot space containing research testing and analysis facilities. The testing room contains a Micromedical System 2000 rotary chair with integrated electrooculography and videooculography systems for the measurement of vestibulo-ocular reflex responses in children. The chair is located within a 6' scleral and head coil system for extremely precise measurement of binocular 3 dimensional eye position and /or head position. The laboratory has 3 computer controlled video systems, two of which are full field projection systems, to create visual stimuli which can be controlled together with chair motion and integrated with video games, movies and images. The laboratory also has laser and slide projection systems which are precisely controlled by 2 dimensional mirror galvanometers. The laboratory contains 2 stand alone electro-oculography systems, four stand alone video-oculography systems including remote, high speed, portable and binocular eye tracking. All of these systems also allow for age appropriate video recording of eye and scene camera output. Data in the laboratory is streamed to VHS tape and digitized on line with Macintosh and PC computers using CED and National Instruments interfaces. Data analysis is performed in adjacent spaces using Spike II, Matlab and specialized analysis programs for the Macintosh running on multiple PC (Pentium 4 Dual Core) and Macintosh (G5) workstations. In addition, the laboratory has a Macintosh G5 radiology analysis station running OsiriX and NIH Image for brainstem, cerebellar, and cortical volumetric analysis and tract tracing, and for extraocular muscle path analysis using high resolution spiral CT and MRI.