The primary focus of my research is the nature and consequences of genetic variability with the species M. tuberculosis. In particular, I'm interested in how global bacterial population genetics may influence vaccine design and how mutations that confer drug resistance may affect reproductive fitness.
Selected Publications:
1. Tsolaki AG, Hirsh AE, , DeRiemer K, Enciso JA, Wong MZ, Hannan M, Goguet
de la Salmoniere YO, Kato-Maeda M and Small PM. Functional and evolutionary
genomics of Mycobacterium tuberculosis: Insights from genomic deletions in 100
strains. Proceedings of the National Academy of Sciences of the United States
of America 101 (14):4865-70. 2004.
2. Hirsh AE, Tsolaki AG, DeRiemer K, Feldman MW, and Small PM. Stable association
between strains of Mycobacterium tuberculosis and their human host populations.
Proceedings of the National Academy of Sciences of the United States of America
101 (14):4871-6, 2004.
3. Kathryn DeRiemer, Ma. de Lourdes García García, , Miriam Bobadilla
del Valle, Manuel Palacios Martínez, Peter M. Small, José Sifuentes
Osornio, Alfredo Ponce de León. Does DOTS work in Populations with Drug
Resistant Tuberculosis. In Press Lancet 2004.
4. Small PM and Fujiwara PI. Management of tuberculosis in the United States.
N Engl J Med. 2001;345:189-200
5. Behr MA, Wilson MA, Gill WP, Salamon H, Schoolnik GK, Rane S, Small PM. Comparative
genomics of BCG vaccines by whole genome DNA microarray. Science 1999; 284:
1520-1523.