Physiology and Biophysics

December 19, 2017

“Sex, drugs and funky rhythms” – Presented by Department of Physiology & Biophysics Lecture Series

Sex, drugs and funky rhythms

Colleen E. Clancy, Ph.D. Professor of Physiology and Membrane Biology Professor of Pharmacology University of California, Davis host: Sharona Gordon Abstract:

Cardiotoxicity in the form of deadly abnormal rhythms is one of the most common and dangerous risks for drugs in development and clinical use. There is an urgent need for new approaches to screen and predict the effects of chemically similar drugs on the cardiac rhythm and to move beyond the QT interval as a diagnostic indicator for arrhythmia. To this end, we present a computational pipeline to predict cardiotoxicity over multiple temporal and spatial scales from the drug chemistry to the cardiac rhythm. We utilize predicted quantitative estimates of ion channel-drug interactions from our companion paper to simulate cardiotoxicity over multiple temporal and spatial scales from the drug chemistry to the cardiac rhythm.