April 21, 2016
PBIO Seminar Series: Dr. Felix Viana
“Molecular physiology of cold-activated TRP channels”
Instituto de Neurociencias de Alicante Institute of Neurosciences, Alicante (Spain)
Visiting Scholar in the Department of Biological Structure, UW
Transient receptor potential (TRP) channels are a family of cationic channels with important roles in many aspects of sensory physiology, from vision to taste. Several of these channels are highly sensitive to temperature and have been shown to play critical roles in thermoreception, thermoregulation and pain. I will provide an overview of our work with two cold-activated channels, TRPA1 and TRPM8, highlighting their differential function in cold transduction, thermoregulation and nociception, and some newly discovered pathophysiological roles outside the nervous system.
host: Bertil Hille