Where the kidney meets the heart: calcium signaling, cardiomyopathies and polycystic kidney disease
Polycystin 2 mutations lead to polycystic kidney disease (PKD), a condition with no cure. Although cysts are the defining characteristic of PKD, cardiac dysfunction is the main cause of mortality, however, the underlying reasons are not known. Polycystin 2 acts both as an intracellular calcium channel and a modulator to alter intracellular signaling pathways. I will present evidence demonstrating that perturbations to calcium signaling result in cysts. Second, I will show that mutations and decreased availability of polycystin 2 results in cardiac dysfunction. Understanding the molecular actions of polycystin 2 in multiple tissue settings will help direct therapeutic efforts into treating PKD.
Ivana Yih-Tsue Kuo, PhD,
Chalk talk, Friday, January 29th, at 9:30 in G-417.
2018 Lamport Lecture Cytoplasmic Dynein and Kinesins in Brain Development and Autophagy Microtubule Motor Proteins Are Involved in a Wide Range of cellular activities. Recent work in our lab has involved the role of the...
Auditory Processing Auditory neurons concerned with temporal processing are the most precise time analyzing units in the mammalian brain. Some auditory neurons exhibit time resolutions of only a few µs. We are interested in the...