Where the kidney meets the heart: calcium signaling, cardiomyopathies and polycystic kidney disease
Polycystin 2 mutations lead to polycystic kidney disease (PKD), a condition with no cure. Although cysts are the defining characteristic of PKD, cardiac dysfunction is the main cause of mortality, however, the underlying reasons are not known. Polycystin 2 acts both as an intracellular calcium channel and a modulator to alter intracellular signaling pathways. I will present evidence demonstrating that perturbations to calcium signaling result in cysts. Second, I will show that mutations and decreased availability of polycystin 2 results in cardiac dysfunction. Understanding the molecular actions of polycystin 2 in multiple tissue settings will help direct therapeutic efforts into treating PKD.
Ivana Yih-Tsue Kuo, PhD,
Chalk talk, Friday, January 29th, at 9:30 in G-417.
Learning and Relearning Movement Human motor learning depends on a suite of brain mechanisms that are driven by different signals and operate on timescales ranging from minutes to years. Understanding these processes requires identifying how...