Physiology and Biophysics

August 5, 2015

Ivana Yih-Tsue Kuo, PhD, Yale University

January 28, 2016 @ 9:30 am – 10:30 am
HSB G-328

Where the kidney meets the heart: calcium signaling, cardiomyopathies and polycystic kidney disease

Polycystin 2 mutations lead to polycystic kidney disease (PKD), a condition with no cure. Although cysts are the defining characteristic of PKD, cardiac dysfunction is the main cause of mortality, however, the underlying reasons are not known. Polycystin 2 acts both as an intracellular calcium channel and a modulator to alter intracellular signaling pathways. I will present evidence demonstrating that perturbations to calcium signaling result in cysts. Second, I will show that mutations and decreased availability of polycystin 2 results in cardiac dysfunction. Understanding the molecular actions of polycystin 2 in multiple tissue settings will help direct therapeutic efforts into treating PKD.

Ivana Yih-Tsue Kuo, PhD,

Yale University

Chalk talk, Friday, January 29th, at 9:30 in G-417.