PBIO SEMINAR SERIES

The rise and fall of REST: creating the nervous system

April 12, 2007
Hille Lecture
12:00-1:00 p.m.
Foege Auditorium S-060

Gail Mandel
Senior Scientist, Vollum, Investigator HHMI Vollum Institute
Speaker's website

Host: Stan Froehner

I will give an overview of our recent work on the role of transcriptional repression in formation of the nervous system. The repressor, REST, will be the focus of the talk, and I will present a model for how dynamic changes in chromatin, orchestrated by REST or its partners, can regulate both neural development as well as plasticity of mature neural cells.