PBIO SEMINAR SERIES

NOS1 & NOS3: The Yin and Yang of Nitric Oxide Regulation of Cardiac Contractility

June 05, 2008
07-08 SEMINAR SERIES
10:30
K-069 H.S.B.

Mark T. Ziolo, PhD
Investigator, Davis Heart & Lung Research Institute  The Ohio State University
Speaker's website

Host: Fernando Santana

Cardiac contractility is regulated by a process termed excitation-contraction coupling (ECC). ECC, and thus contractility, is modulated by many signaling pathways; one of which is nitric oxide (NO). NO is produced via enzymes termed NO synthase (NOS). Cardiac myocytes constitutively express two distinct isoforms of NOS: neuronal (nNOS, NOS1) and endothelial (eNOS, NOS3). However, the NO-mediated effects on contractility are controversial. My presentation will focus on the contractile effects, end targets and signaling pathways of NOS1 and NOS3.