PBIO SEMINAR SERIES

The essential role of dendritic excitability for synaptic integration and plasticity in the hippocampus

Wednesday - May 03, 2006
05-06 SEMINAR SERIES

Nelson Spruston
Associate Professor Dept of Neurobiology and Physiology. Northwestern University
Speaker's website

Host: Andrés Barría

I will present evidence that the presence of voltage-gated channels in the dendrites is critical for the function of CA1 pyramidal neurons in the hippocampus. Evidence using patch-clamp recording, electron microscopy, and computational approaches suggest that dendritic excitability plays a central role in the integration of synaptic inputs to the dendrites as well as in synaptic plasticity.