PBIO SEMINAR SERIES

Phosphoinositide lipid signals regulate ion channels and many cellular functions

Wednesday - December 07, 2005
05-06 SEMINAR SERIES
K-069

Bertil Hille
Professor University of Washington
Speaker's website

Host: Stan Froehner

We inquired how activating muscarinic receptors turns off several ion channels in neurons and found that the signaling pathway uses Gq and phospholipase C to cleave the PI(4,5)P₂ inositol lipid in the plasma membrane. I will show that depletion of this signaling lipid rather than the generation of new second messenger products is the source of channel modulation and, in far broader terms, will discuss the growing recognition of dynamic regulation of many cellular functions by phosphoinositide lipids