Location: HSB G-328, 10:30am (unless otherwise noted)
February 06, 2014 - 2013-2014 SEMINAR SERIES
Jorge Alegre-Cebollada, Columbia University
Host: Stan Froehner
Mechanical forces are the number one protein denaturant in cells. How proteins unfold and refold under force has strong implications in physiological responses such as muscle elasticity. I will navigate through the latest developments in single-molecule force spectroscopy by Atomic Force Microscopy and Magnetic Tweezers, the techniques of choice to examine mechanical protein folding and unfolding. I will discuss how the elasticity of muscle is modulated biochemically through the modification of cryptic residues in titin that become exposed following protein mechanical unfolding. I will outline anticipated future developments in the new field of mechanobiochemistry
Alt Time: 10:30 a.m.
Alt Location: HSB G-328