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PBIO SEMINAR SERIES

Location: HSB G-328, 10:30am (unless otherwise noted)

February 06, 2014

"Mechanobiochemistry of the giant protein titin "

Jorge Alegre-Cebollada, Columbia University

Host: Stan Froehner

Mechanical forces are the number one protein denaturant in cells. How proteins unfold and refold under force has strong implications in physiological responses such as muscle elasticity. I will navigate through the latest developments in single-molecule force spectroscopy by Atomic Force Microscopy and Magnetic Tweezers, the techniques of choice to examine mechanical protein folding and unfolding. I will discuss how the elasticity of muscle is modulated biochemically through the modification of cryptic residues in titin that become exposed following protein mechanical unfolding. I will outline anticipated future developments in the new field of mechanobiochemistry