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PBIO SEMINAR SERIES

Location: HSB G-328, 10:30am (unless otherwise noted)

March 13, 2014

"Violation of Mendel's First Law: biased chromosome segregation in meiosis"

Michael Lampson, Associate Professor of Biology, U Penn
Speaker's website

Host: Chip Asbury

I will discuss biased chromosome segregation in meiosis, also known as meiotic drive. Because of the inherent asymmetry of female meiosis, only chromosomes that segregate to the egg go into a gamete. Any bias away from random segregation, in violation of Mendelís First Law, is therefore under strong positive selection and has significant consequences for centromere and karyotype evolution and for speciation. Using Robertsonian fusions in mouse oocytes as a model to understand the cell biological mechanisms underlying meiotic drive, I will discuss how the direction of drive is determined and how changes in direction can lead to dramatic changes in karyotype. Our findings provide insight into mechanisms underlying meiotic drive and link the basic cell biology of chromosome segregation to karyotype evolution and speciation.