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PBIO SEMINAR SERIES

Location: HSB G-328, 10:30am (unless otherwise noted)

April 10, 2014

"Deafness mutations provide insights into the structure of the hair cell mechanotransducer channel"

Robert Fettiplace, Steenbock Professor of Neural and Behavioral Sciences, University of Wisconsin
Speaker's website

Host: Peter Detwiler

Over the last decade, there has been significant progress in understanding the molecular mechanism of transduction in hair cells of the inner ear. Advances have stemmed largely from studies of inherited deafnesses, such as Usher syndrome, leading to the discovery of some of the molecules of the transduction complex, including the tip link and its attachments. However, the mechanotransducer channel is still not firmly identified but a possible candidate has recently emerged. This is the transmembrane channel-like (TMC) protein, mutations of which are one of the most common sources of non syndromic deafness in humans and mice. I shall describe our experiments to dissect the contributions of TMCs and other deafness proteins to operation of the mechanotransducer channel.