Physiology and Biophysics

2017-2018 Seminar Series

Sep
21
Thu
2017
PBIO Seminar Series: Andrei Smertenko @ HSB G-328
Sep 21 @ 9:30 am – 10:30 am

How plants conquer the space: the cell’s flying plates

Plant cytokinesis is orchestrated by a specialized structure, the phragmoplast. The phragmoplast first occurred in representatives of Charophyte algae and then became the main division apparatus in land plants.  Major cellular activities, including cytoskeletal dynamics, vesicle trafficking, membrane assembly, and cell wall biosynthesis, cooperate in the phragmoplast under the guidance of a complex signaling network. My research focuses on the self-organization processes that govern phragmoplast functions. I will give a general overview of plant cytokinesis, and present our recent data on the gamma-tubulin independent microtubule nucleation by the plant-specific protein MACERATOR and a conserved member of TPX2 protein family.

Andrei Smertenko, Ph.D.
Assistant Professor, Molecular Plant Sciences
Washington State University

host: Linda Wordeman

Oct
12
Thu
2017
PBIO Seminar Series: Liangyi Chen @ HSB G-328
Oct 12 @ 9:30 am – 10:30 am

High spatiotemporal resolution, three-dimension fluorescence imaging of biological samples in vivo

Dr. Liangyi Chen
Professor
Laboratory of Cell Secretion and Metabolism
Institute of Molecular Medicine,
Peking University, Beijing, China

Host: Bertil Hille

Abstract: I will give two stories. (i) One story describes unpublished ultrasensitive Hessian structured illumination microscopy that enables ultrafast and long-term super-resolution (SR) live-cell imaging. At a photon dose one order less than point-scanning microscopy, Hessian-SIM has achieved 88-nm and 188-Hz spatial-temporal resolution for live cells imaging and lasted thousands of images without artifacts. Operating at 1 Hz, Hessian-SIM enables hour-long, time-lapse SR imaging with mitigatable photobleaching, highlighting the possibility of achieving SR imaging with commonly used fluorophores for an unlimited period of time. (ii) The second story is our recent Nature Methods paper, our invention of the fast high-resolution miniature two-photon microscope for brain imaging in freely-behaving mice at the single-spine level. With a headpiece weighing 2.15 g and a new type of hollow-core photonic crystal
fiber to deliver 920-nm femtosecond laser pulses, the mini-microscope is capable of imaging commonly used biosensors at high spatiotemporal resolution (0.64 μm laterally and 3.35 μm axially, 40 Hz at 256 × 256 pixels). It compares favorably with benchtop two-photon microscopy and miniature wide-field fluorescence microscopy in the structural and functional imaging of Thy1-GFP- or GCaMP6f-labeled neurons. Further, we demonstrate its unique application and robustness with hour-long recording of neuronal activities down to the level of spines in mice experiencing vigorous body and head movements or engaging in social interaction.

Oct
26
Thu
2017
PBIO Seminar Series: Brian Kalmbach @ HSB G-328
Oct 26 @ 9:30 am – 10:30 am

“Of Mice and Men: Intrinsic Membrane Properties of Human Cortical Pyramidal Neurons”

Brian Kalmbach, Ph.D.

Allen Institute for Brain Science

host: Nikolai Dembrow

Nov
2
Thu
2017
2017 Lamport Lecture – Gilles Laurent @ T-739 HSB
Nov 2 @ 4:00 pm – 5:00 pm

Evolution and brain computation

I will introduce our work towards identifying principles of brain function and computation, focused on using comparative approaches and exploiting unusual model systems (reptiles, cephalopods) to study sleep, texture perception and cerebral cortex evolution.

Gilles Laurent, PhD, DVM

Director

Max Planck Institute for Brain Research

http://www.brain.mpg.de/home/

 

4:00 PM

Location: T-739, HSB

 

host: Stan Froehner

Dec
7
Thu
2017
PBIO Seminar Series: Nikolai Dembrow @ HSB G-328
Dec 7 @ 9:30 am – 10:30 am

Title: TBA

Nikolai Dembrow, PhD

host: Stan Froehner

Jan
9
Tue
2018
PBIO Seminar: Rishidev Chaudhuri @ HSB G-328
Jan 9 @ 9:30 am – 10:30 am

Rishidev Chaudhuri, PhD.

Host: Stanley C. Froehner

Jan
16
Tue
2018
PBIO Seminar: Ashok Litwin-Kumar, PhD @ HSB G-328
Jan 16 @ 9:30 am – 10:30 am

Randomness and structure in neural representations for learning

Ashok Litwin-Kumar, PhD

Host: Stanley C. Froehner

Jan
25
Thu
2018
PBIO Seminar Series: Amy Bastian, PhD @ HSB G-328
Jan 25 @ 9:30 am – 10:30 am

Learning and Relearning Movement

Human motor learning depends on a suite of brain mechanisms that are driven by different signals and operate on timescales ranging from minutes to years. Understanding these processes requires identifying how new movement patterns are normally acquired, retained, and generalized, as well as the effects of distinct brain lesions. The lecture focuses on normal and abnormal motor learning and how we can use this information to improve rehabilitation for individuals with neurological damage

Amy Bastian, Ph.D.
Professor of Neuroscience
Johns Hopkins University

 

Host: John Tuthill

 

Feb
1
Thu
2018
PBIO Seminar: Julijana Gjorgieva, PhD @ HSB G-328
Feb 1 @ 9:30 am – 10:30 am

Julijana Gjorgieva, PhD

Host: Stanley C. Froehner

Feb
5
Mon
2018
PBIO Seminar: Scott Linderman, PhD @ HSB G-328
Feb 5 @ 9:30 am – 10:30 am

Scott Linderman, PhD

Host: Stanley C. Froehner

Feb
15
Thu
2018
PBIO Seminar Series: Bernhard Flucher @ HSB G-328
Feb 15 @ 9:30 am – 10:30 am

TBD

Bernhard Flucher

University of Innsbruck

May
3
Thu
2018
2018 Hille Lecture – Doris Tsao @ HSB G-328
May 3 all-day

Doris Tsao

Professor of Biology
HHMI Investigator
California Institute of Technology

time: TBD
location: TBD

host: Stan Froehner

May
10
Thu
2018
2018 Crill Lecture – J. Anthony Movshon @ HSB G-328
May 10 all-day

Time & Location TBA

J. Anthony Movshon, PhD

Professor, Department of Ophthalmology

Professor, Department of Neuroscience and Physiology