Physiology and Biophysics

Seminars

Oct
3
Tue
2017
“Photoacoustic Imaging and Thrombolysis with Phase-Change Contrast Agents” – Presented by The Center for Cardiovascular Biology and The Mitochondria and Metabolism Center @ South Lake Union
Oct 3 @ 9:00 am – 10:00 am

Lilo Pozzo, PhD
Associate Professor of Chemical Engineering
University of Washington

“Sensitive in-vitro Imaging and Detection” – Presented by The Center for Cardiovascular Biology and the Mitochondria and Metabolism Center @ South Lake Union
Oct 3 @ 9:00 am – 10:00 am

Xiaohu Gao, Ph.D.
Associate Professor of Bioengineering
University of Washington

“Research Update from the WWAMI region Practice and Research Network” – Presented by Department of Family Medicine @ Roosevelt 1 Building
Oct 3 @ 12:00 pm – 1:00 pm

Allison M. Cole, MD, MPH, Assistant Professor, Family Medicine
Associate Director WWAMI region Practice and Research Network,
Institute of Translational Health Sciences

Laura-Mae Baldwin, MD, MPH, Professor, Family Medicine
Director, Community Engagement
Institute of Translational Health Sciences

“Rules of engagement: molecular arms races between viral and host genomes” – Presented by Department of Pharmacology @ Health Sciences B uilding
Oct 3 @ 2:30 pm – 3:30 pm

Harmit Malik, PhD
Member, Division of Basic Sciences, FHCRC
HHMI Investigator

Oct
4
Wed
2017
“Increasing Afterload Promotes Maturation of hiPSC-CMs in Engineered Heart Tissues” – Presented by the Center for Cardiovascular Biology @ South Lake Union
Oct 4 @ 11:30 am – 12:30 pm

Andrea Leonard, PhD, Postdoctoral Fellow
Department of Mechanical Engineering
Sniadecki Laboratory

“Episodic disorders of autonomic function: A practical Guide to diagnosis and management” – Presented by Department of Neurology Lecture Series @ Harborview Medical Center
Oct 4 @ 12:00 pm – 1:00 pm

John Oakley, MD, Assistant Professor
Department of Neurology
University of Washington

“Mechanism of DNA Unwinding in Eukaryotic Transcription Initiation” – Presented by Division of Basic Sciences @ Fred Hutchinson Cancer Research Center
Oct 4 @ 12:00 pm – 1:00 pm

Eric Galburt, Ph.D.
Washington University School of Medicine
Department of Biochemistry and Molecular Biophysics

Oct
5
Thu
2017
“Precision medicine and the health of the public” – Presented by Department of Medicine Grand Rounds @ Health Sciences Building
Oct 5 @ 8:00 am – 9:00 am

Bruce M. Psaty, MD, PhD
Co-director, Cardiovascular Health Research Unit
Professor, Medicine & Epidemiology
University of Washington

“Selective autophagy in the fight against age-related disorders” – Presented by Division of Basic Sciences @ Fred Hutchinson Cancer Research Center
Oct 5 @ 12:00 pm – 1:00 pm

Ama Maria Cuervo, Ph.D.
Albert Einstein College of Medicine
Department of Developmental and Molecular Biology

“Dysregulated TLR7 signaling drives anemia via development of unique hemophagocytes” – Presented by IMMUN 550 Research-in-Progress (RIP) @ South Lake Union
Oct 5 @ 3:30 pm – 4:30 pm

Holly Akilesh, PhD
Postdoctoral Fellow
Hamerman Lab

“Myelin-Specific CD8+ T cells Exacerbate CNS Autoimmunity and Increase Clinical Signs of Brain Inflammation” – Presented by IMMUN 550 Research-in-Progress (RIP) @ South Lake Union
Oct 5 @ 3:30 pm – 4:30 pm

Katie Wagner
Graduate Student
Goverman Lab

“Neurologic Constellations: Prosophagnosia and its Perceptual Syndromes” – Presented by Department of Neurology Grand Rounds @ Health Sciences Building
Oct 5 @ 4:30 pm – 5:30 pm

Jason Barton, M.D., Ph.D., FRCP (C)
Canada Research Chair, Marianne Koerner Chair in Brain Disease
Department of Neurology, Ophthalmology and Visual Sciences

Oct
6
Fri
2017
“Molecular Mechanisms of DNA Replication Across UV-Induced DNS Lesions and Novel Approaches to Suppress UV Mutagenesis” – A Master’s Thesis Defense – Department of Oral Health Sciences @ Health Sciences Building
Oct 6 @ 1:30 pm – 2:30 pm

Lavanya Samraj
Master’s Candidate, Oral Biology
School of Dentistry

Oct
9
Mon
2017
Postdoc Seminar – Presented by Department of Biology @ Hitchcock Hall
Oct 9 @ 12:00 pm – 1:30 pm

Dr. Callin Switzer (Daniel Lab)
Dr. Mallorie Taylor-Teeples (Nemhauser Lab)
Dr. Floris van Breugel (Riffell Lab)
Dr. Natasha Gownaris (Boersma Lab)

“Can Minimization Improve the Usefulness of Clinical Trials?” – Presented by Department of Oral Health Sciences @ Health Sciences Building
Oct 9 @ 12:30 pm – 1:30 pm

Donald Taves, MD, MPH, PhD
Affiliated Associate Professor
Oral Health Sciences, University of Washington

“Oh To Be Seventeen Again: IL-17 signaling in autoimmunity and host defense” – Presented by Department of Immunology @ South Lake Union
Oct 9 @ 3:30 pm – 4:30 pm

Sarah Gaffen, PhD
Gerald P. Rodnan Endowed Chair and Professor of
Rheumatology & Clinical Immunology
University of Pittsburgh

Oct
10
Tue
2017
“Myosin Binding Protein-C: Stepping on both the gas and brake to regulate cardiac contractility” – Presented by Center for Cardiovascular Biology and Mitochrondria and Metabolism Center @ South Lake Union
Oct 10 @ 9:00 am – 10:00 am

David Warshaw, PhD, Professor and Chair
Molecular Physiology & Biophysics
University of Vermont

“Defects in mRNA translation and neurodegeneration” Presented by Department of Biochemistry @ Health Sciences Building
Oct 10 @ 10:30 am – 11:30 am

Susan Ackerman, Ph.D.
University of California
San Diego, California

“Evolution of Drift robustness: The curious case of ENA editing in Trypanosomes” – Presented by Division of Basic Sciences @ Fre Hutchinson Cancer Research Center
Oct 10 @ 12:00 pm – 1:00 pm

Chris Adami, Ph.D., Michigan State University
Departments of Microbiology and Molecular Genetics &
Physics and Astronomy

“Rewiring Genome Structure with Programmable CRISPR-Cas Tools to Physically Reposition Genes” – Presented by Department of Pharmacology @ Health Sciences Building
Oct 10 @ 2:30 pm – 3:30 pm

Jesse G. Zalatan, PhD, Assistant Professor
Department of Chemistry
University of Washington

Sensory Science – SLU Collaborative UW Medicine, Fred Hutchinson Research Center, Allen Institute
Oct 10 @ 4:00 pm – 5:00 pm

Thomas A. Reh, PhD, Professor, Biological Structure, UW
Jihong Bai, PhD, Associate Member, Basic Sciences Division, Fred Hutch
Severine Durand, PhD, Scientist II, Allen Institute for Brain Science

Oct
12
Thu
2017
“Advocacy and the Internal Medicine Physician” – Presented by Department of Medicine Grand Rounds @ Health Sciences Building
Oct 12 @ 8:00 am – 9:00 am

Genevieve Pagalilauan, MD, Associate Professor
Department of Medicine, Division of General Internal Medicine
UW School of Medicine

“High spatiotemporal resolution, Three-dimension fluorescence imaging of biological samples in vivo” – Presented by Department of Physiology & Biophysics @ Health Sciences Building
Oct 12 @ 9:30 am – 10:30 am

Dr. Liangyi Chen, Professor
Laboratory of Cell Secretion and Metabolism
Institute of Molecular Medicine
Peking University, Beijing, China

PBIO Seminar Series: Liangyi Chen @ HSB G-328
Oct 12 @ 9:30 am – 10:30 am

High spatiotemporal resolution, three-dimension fluorescence imaging of biological samples in vivo

Dr. Liangyi Chen
Professor
Laboratory of Cell Secretion and Metabolism
Institute of Molecular Medicine,
Peking University, Beijing, China

Host: Bertil Hille

Abstract: I will give two stories. (i) One story describes unpublished ultrasensitive Hessian structured illumination microscopy that enables ultrafast and long-term super-resolution (SR) live-cell imaging. At a photon dose one order less than point-scanning microscopy, Hessian-SIM has achieved 88-nm and 188-Hz spatial-temporal resolution for live cells imaging and lasted thousands of images without artifacts. Operating at 1 Hz, Hessian-SIM enables hour-long, time-lapse SR imaging with mitigatable photobleaching, highlighting the possibility of achieving SR imaging with commonly used fluorophores for an unlimited period of time. (ii) The second story is our recent Nature Methods paper, our invention of the fast high-resolution miniature two-photon microscope for brain imaging in freely-behaving mice at the single-spine level. With a headpiece weighing 2.15 g and a new type of hollow-core photonic crystal
fiber to deliver 920-nm femtosecond laser pulses, the mini-microscope is capable of imaging commonly used biosensors at high spatiotemporal resolution (0.64 μm laterally and 3.35 μm axially, 40 Hz at 256 × 256 pixels). It compares favorably with benchtop two-photon microscopy and miniature wide-field fluorescence microscopy in the structural and functional imaging of Thy1-GFP- or GCaMP6f-labeled neurons. Further, we demonstrate its unique application and robustness with hour-long recording of neuronal activities down to the level of spines in mice experiencing vigorous body and head movements or engaging in social interaction.

“A modest change in regulation of NOD1 expression has a major impact on inflammation and gastric cancer” – Presented by Department of Immunology – IMMUN 550 Research-in-Progress (RIP) @ South Lake Union
Oct 12 @ 3:30 pm – 4:30 pm

Leah Rommereim, PhD
Postdoctoral Fellow in the Subramanian Lab
Department of Immunology

“BCAP promotes TLR-induced IFNa induction in pDC” – Presented by Department of Immunology – IMMUN 550 Research-in-Progress (RIP) @ South Lake Union
Oct 12 @ 3:30 pm – 4:30 pm

Talyn Chu, Graduate Student
Hamerman Lab
Department of Immunology, UW

“Screening for Inflammatory Neuropathies” – Presented by Department of Neurology Grand Rounds @ Health Sciences Building
Oct 12 @ 4:30 pm – 5:30 pm

Chafic Karam, M.D., Assistant Professor
Department of Neurology
Oregon Health & Science University

Oct
13
Fri
2017
“COMPASS Trial: Insights into Aspirin and Rivaroxaban Combined Therapy” – Presented by Division of Cardiology Grand Rounds @ Health Sciences Building
Oct 13 @ 7:30 am – 8:30 am

Kelley Branch, MD, Msc, Associate Professor
Internal Medicine/Cardiology, UW

Jeff Probstfield, MD, Professor
Internal Medicine/Cardiology, UW

“Quantifying the Role that Terrestrial Ecosystems Play in Earth’s Climate” – Presented by Department of Atmospheric Sciences @ JHN 075
Oct 13 @ 3:30 pm – 4:30 pm

Professor Abigail Swann
UW Atmospheric Sciences & Biology

Oct
23
Mon
2017
“Evolutionary perspectives on aging: thrifty telomeres and intergenerational plasticity” – Presented by Biology of Aging and the Department of Pathology @ Genome Sciences Building
Oct 23 @ 12:00 pm – 1:30 pm

Dan Eisenberg, PhD, Assistant Professor
Department of Anthropology
University of Washington