Physiology and Biophysics

Seminars

Oct
12
Thu
2017
“Advocacy and the Internal Medicine Physician” – Presented by Department of Medicine Grand Rounds @ Health Sciences Building
Oct 12 @ 8:00 am – 9:00 am

Genevieve Pagalilauan, MD, Associate Professor
Department of Medicine, Division of General Internal Medicine
UW School of Medicine

“High spatiotemporal resolution, Three-dimension fluorescence imaging of biological samples in vivo” – Presented by Department of Physiology & Biophysics @ Health Sciences Building
Oct 12 @ 9:30 am – 10:30 am

Dr. Liangyi Chen, Professor
Laboratory of Cell Secretion and Metabolism
Institute of Molecular Medicine
Peking University, Beijing, China

PBIO Seminar Series: Liangyi Chen @ HSB G-328
Oct 12 @ 9:30 am – 10:30 am

High spatiotemporal resolution, three-dimension fluorescence imaging of biological samples in vivo

Dr. Liangyi Chen
Professor
Laboratory of Cell Secretion and Metabolism
Institute of Molecular Medicine,
Peking University, Beijing, China

Host: Bertil Hille

Abstract: I will give two stories. (i) One story describes unpublished ultrasensitive Hessian structured illumination microscopy that enables ultrafast and long-term super-resolution (SR) live-cell imaging. At a photon dose one order less than point-scanning microscopy, Hessian-SIM has achieved 88-nm and 188-Hz spatial-temporal resolution for live cells imaging and lasted thousands of images without artifacts. Operating at 1 Hz, Hessian-SIM enables hour-long, time-lapse SR imaging with mitigatable photobleaching, highlighting the possibility of achieving SR imaging with commonly used fluorophores for an unlimited period of time. (ii) The second story is our recent Nature Methods paper, our invention of the fast high-resolution miniature two-photon microscope for brain imaging in freely-behaving mice at the single-spine level. With a headpiece weighing 2.15 g and a new type of hollow-core photonic crystal
fiber to deliver 920-nm femtosecond laser pulses, the mini-microscope is capable of imaging commonly used biosensors at high spatiotemporal resolution (0.64 μm laterally and 3.35 μm axially, 40 Hz at 256 × 256 pixels). It compares favorably with benchtop two-photon microscopy and miniature wide-field fluorescence microscopy in the structural and functional imaging of Thy1-GFP- or GCaMP6f-labeled neurons. Further, we demonstrate its unique application and robustness with hour-long recording of neuronal activities down to the level of spines in mice experiencing vigorous body and head movements or engaging in social interaction.

“A modest change in regulation of NOD1 expression has a major impact on inflammation and gastric cancer” – Presented by Department of Immunology – IMMUN 550 Research-in-Progress (RIP) @ South Lake Union
Oct 12 @ 3:30 pm – 4:30 pm

Leah Rommereim, PhD
Postdoctoral Fellow in the Subramanian Lab
Department of Immunology

“BCAP promotes TLR-induced IFNa induction in pDC” – Presented by Department of Immunology – IMMUN 550 Research-in-Progress (RIP) @ South Lake Union
Oct 12 @ 3:30 pm – 4:30 pm

Talyn Chu, Graduate Student
Hamerman Lab
Department of Immunology, UW

“Screening for Inflammatory Neuropathies” – Presented by Department of Neurology Grand Rounds @ Health Sciences Building
Oct 12 @ 4:30 pm – 5:30 pm

Chafic Karam, M.D., Assistant Professor
Department of Neurology
Oregon Health & Science University

Oct
13
Fri
2017
“COMPASS Trial: Insights into Aspirin and Rivaroxaban Combined Therapy” – Presented by Division of Cardiology Grand Rounds @ Health Sciences Building
Oct 13 @ 7:30 am – 8:30 am

Kelley Branch, MD, Msc, Associate Professor
Internal Medicine/Cardiology, UW

Jeff Probstfield, MD, Professor
Internal Medicine/Cardiology, UW

“Quantifying the Role that Terrestrial Ecosystems Play in Earth’s Climate” – Presented by Department of Atmospheric Sciences @ JHN 075
Oct 13 @ 3:30 pm – 4:30 pm

Professor Abigail Swann
UW Atmospheric Sciences & Biology

Oct
23
Mon
2017
“Evolutionary perspectives on aging: thrifty telomeres and intergenerational plasticity” – Presented by Biology of Aging and the Department of Pathology @ Genome Sciences Building
Oct 23 @ 12:00 pm – 1:30 pm

Dan Eisenberg, PhD, Assistant Professor
Department of Anthropology
University of Washington

“Identifying Genes Responsible for Acquired Deafness and Evaluating the Risks of Hearing Loss for Dental Practices” – Presented by Department of Oral Health Sciences @ Health Sciences Building
Oct 23 @ 12:30 pm – 1:30 pm

Braulio Peguero, Ph.D.
UW Oral Health Science

“Breathing Matters!” – Graduate Program in Neuroscience @ Health Sciences Building
Oct 23 @ 3:30 pm – 4:30 pm

Jack Feldman, PhD
Distinguished Professor of Neurobiology
UCLA

“Investigating the potential of individual naïve B cell” – Presented by Department Immunology 573 Seminar Series @ South Lake Union
Oct 23 @ 3:30 pm – 4:30 pm

Justin Taylor, PhD
Assistant Member
Fred Hutchinson Cancer Research Center

Oct
24
Tue
2017
“Gene replacement vs gene editing for muscular dystrophy” – Presented by The Center for Cardiovascular Biology and The Mitochondria and Metabolism Center Breakfast Club @ South Lake Union
Oct 24 @ 9:00 am – 10:00 am

Jeff Chamberlain, PhD, Professor
Neurology, Medicine, and Biochemistry
University of Washington

“Rethinking protein homeostasis in a metazoan: A reaction to damage or anticipatory control?” – Presented by Department of Biochemistry @ Health Sciences Building
Oct 24 @ 10:30 am – 11:30 am

Veena Prahlad, Ph.D.
University of Iowa

“Here be dragons: the meaning of Phenotypic “noise” in biological systems” – Presented by Division of Basic Sciences @ Fred Hutchinson Cancer Reseach Center
Oct 24 @ 12:00 pm – 1:00 pm

Joe Nadeau, Ph.D.
Pacific Northwest Research Institute

“Design of Self-assembling protein nanomaterials for vaccines and biologics delivery” – Presented by Department of Pharmacology @ Health Sciences Building
Oct 24 @ 2:30 pm – 3:30 pm

Neil King, PhD, Assistant Professor
Department of Biochemistry
University of Washington

“Cis-regulatory motifs for translation control in bacteria and viruses” – Presented by Department of Microbiology @ Health Sciences Building
Oct 24 @ 4:00 pm – 5:00 pm

Arvind “Rasi” Subramaniam, Ph.D., Assistant Member
Basic Sciences Division and Computational Biology
Program of Public Health Sciences Division
Fred Hutchinson Cancer Research Center

Oct
25
Wed
2017
“Spanchno-hormonal Mechanisms of Cystic Fibrosis Related Diabetes” – Presented by Diabetes Research Center @ South Lake Union
Oct 25 @ 9:00 am – 10:00 am

Andrew Norris, MD, PhD, Associate Professor
Pediatrics & Biochemistry
University of Iowa

“Advanced Optical Methods for Studying and Controlling Cardiac Electrical Activity” – Presented by Institute for Stem Cell & Regenerative Medicine @ South Lake Union
Oct 25 @ 11:30 am – 12:30 pm

Dr. Claudia Crocini, PhD
University of Colorado, Boulder, CO
Lab of Dr. Leslie Leinwand

Stroke: “An Overview of Thrombectomy Trials” – Presented by Department of Neurology Seminar Series @ Harborview Medical Center
Oct 25 @ 12:00 pm – 1:00 pm

Dr. Rizwan Kalani, M.D., Senior Fellow
Department of Neurology
University of Washington

Oct
26
Thu
2017
“Whither Medicine? A Look to the East” – Presented by Department of Medicine Grand Rounds @ Health Sciences Building
Oct 26 @ 8:00 am – 9:00 am

Sum Lee, MD, PhD, Professor Emeritus
Department of Medicine, Division of Gastroenterology
University of Washington School of Medicine

“TBA” – Presented by Department of Physiology & Biophysics @ Health Sciences Building
Oct 26 @ 9:30 am – 10:30 am

Brian Kalmbach, PhD
Allen Institute for Brain Science

PBIO Seminar Series: Brian Kalmbach @ HSB G-328
Oct 26 @ 9:30 am – 10:30 am

“Of Mice and Men: Intrinsic Membrane Properties of Human Cortical Pyramidal Neurons”

Brian Kalmbach, Ph.D.

Allen Institute for Brain Science

host: Nikolai Dembrow

“Protein Synthesis Control in Cancer Etiology and Therapeutics” – Presented by UW Medicine – Science in Medicine @ Genome Sciences Building
Oct 26 @ 1:00 pm – 2:00 pm

Andrew Hsieh, M.D., Assistant Professor
Molecular & Cellular Biology and
Division of Medical Oncology, University of Washington
Assistant Member, Human Biology and Clinical Research, FHCRC

“IRF1: The fork in the road to interferon-induced inflammation” – Presented by IMMUN 550 Research-in-Progress (RIP) @ South Lake Union
Oct 26 @ 3:30 pm – 4:30 pm

Adriana Forero, PhD, Postdoctoral Fellow, Ram Lab

“SUMO: Wrestling with Type I Interferons” – Presented by IMMUN 550 Research-in-Progress (RIP) @ South Lake Union
Oct 26 @ 3:30 pm – 4:30 pm

Ty Crowl, Graduate Student, Stetson Lab

“Disease Dynamics and Evolution from Communicable to Vector Borne Disease – Presented by Department of Applied Mathematics – Boeing Distinguished Colloquia @ Smith Hall
Oct 26 @ 4:00 pm – 5:00 pm

Carlos Castillo-Chavez
Arizona State University

“Infusions in Neuromuscular Disease” – Presented by Department of Neurology Grand Rounds @ Health Sciences Building
Oct 26 @ 4:30 pm – 5:30 pm

Jane Distad, M.D., Associate Professor
Department of Neurology
University of Washington School of Medicine

“The Devil is in the Daily Details: Journey to My Unexpected Dream Job in Biotech” – Bioscience Careers Seminar Series @ Health Sciences Building
Oct 26 @ 5:00 pm – 6:00 pm

Heather Van Epps, PhD
Principal Scientist in Translational Research
Seattle Genetics

Oct
27
Fri
2017
“The Future of Cardiac Rehabilitation” – Presented by Division of Cardiology Grand Rounds @ Health Sciences Building
Oct 27 @ 7:30 am – 8:30 am

Alexis Beatty, MD, Acting Assistant Professor
Medicine/Cardiology
University of Washington