Physiology and Biophysics

Seminars

Oct
12
Thu
2017
“Advocacy and the Internal Medicine Physician” – Presented by Department of Medicine Grand Rounds @ Health Sciences Building
Oct 12 @ 8:00 am – 9:00 am

Genevieve Pagalilauan, MD, Associate Professor
Department of Medicine, Division of General Internal Medicine
UW School of Medicine

“High spatiotemporal resolution, Three-dimension fluorescence imaging of biological samples in vivo” – Presented by Department of Physiology & Biophysics @ Health Sciences Building
Oct 12 @ 9:30 am – 10:30 am

Dr. Liangyi Chen, Professor
Laboratory of Cell Secretion and Metabolism
Institute of Molecular Medicine
Peking University, Beijing, China

PBIO Seminar Series: Liangyi Chen @ HSB G-328
Oct 12 @ 9:30 am – 10:30 am

High spatiotemporal resolution, three-dimension fluorescence imaging of biological samples in vivo

Dr. Liangyi Chen
Professor
Laboratory of Cell Secretion and Metabolism
Institute of Molecular Medicine,
Peking University, Beijing, China

Host: Bertil Hille

Abstract: I will give two stories. (i) One story describes unpublished ultrasensitive Hessian structured illumination microscopy that enables ultrafast and long-term super-resolution (SR) live-cell imaging. At a photon dose one order less than point-scanning microscopy, Hessian-SIM has achieved 88-nm and 188-Hz spatial-temporal resolution for live cells imaging and lasted thousands of images without artifacts. Operating at 1 Hz, Hessian-SIM enables hour-long, time-lapse SR imaging with mitigatable photobleaching, highlighting the possibility of achieving SR imaging with commonly used fluorophores for an unlimited period of time. (ii) The second story is our recent Nature Methods paper, our invention of the fast high-resolution miniature two-photon microscope for brain imaging in freely-behaving mice at the single-spine level. With a headpiece weighing 2.15 g and a new type of hollow-core photonic crystal
fiber to deliver 920-nm femtosecond laser pulses, the mini-microscope is capable of imaging commonly used biosensors at high spatiotemporal resolution (0.64 μm laterally and 3.35 μm axially, 40 Hz at 256 × 256 pixels). It compares favorably with benchtop two-photon microscopy and miniature wide-field fluorescence microscopy in the structural and functional imaging of Thy1-GFP- or GCaMP6f-labeled neurons. Further, we demonstrate its unique application and robustness with hour-long recording of neuronal activities down to the level of spines in mice experiencing vigorous body and head movements or engaging in social interaction.

“A modest change in regulation of NOD1 expression has a major impact on inflammation and gastric cancer” – Presented by Department of Immunology – IMMUN 550 Research-in-Progress (RIP) @ South Lake Union
Oct 12 @ 3:30 pm – 4:30 pm

Leah Rommereim, PhD
Postdoctoral Fellow in the Subramanian Lab
Department of Immunology

“BCAP promotes TLR-induced IFNa induction in pDC” – Presented by Department of Immunology – IMMUN 550 Research-in-Progress (RIP) @ South Lake Union
Oct 12 @ 3:30 pm – 4:30 pm

Talyn Chu, Graduate Student
Hamerman Lab
Department of Immunology, UW

“Screening for Inflammatory Neuropathies” – Presented by Department of Neurology Grand Rounds @ Health Sciences Building
Oct 12 @ 4:30 pm – 5:30 pm

Chafic Karam, M.D., Assistant Professor
Department of Neurology
Oregon Health & Science University

Oct
13
Fri
2017
“COMPASS Trial: Insights into Aspirin and Rivaroxaban Combined Therapy” – Presented by Division of Cardiology Grand Rounds @ Health Sciences Building
Oct 13 @ 7:30 am – 8:30 am

Kelley Branch, MD, Msc, Associate Professor
Internal Medicine/Cardiology, UW

Jeff Probstfield, MD, Professor
Internal Medicine/Cardiology, UW

“Quantifying the Role that Terrestrial Ecosystems Play in Earth’s Climate” – Presented by Department of Atmospheric Sciences @ JHN 075
Oct 13 @ 3:30 pm – 4:30 pm

Professor Abigail Swann
UW Atmospheric Sciences & Biology

Oct
26
Thu
2017
PBIO Seminar Series: Brian Kalmbach @ HSB G-328
Oct 26 @ 9:30 am – 10:30 am

seminar title: T.B.A

 

Brian Kalmbach, Ph.D.

Allen Institute for Brain Science

host: Nikolai Dembrow

Nov
2
Thu
2017
2017 Lamport Lecture – Gilles Laurent @ T-739 HSB
Nov 2 @ 4:00 pm – 5:00 pm

Evolution and brain computation

I will introduce our work towards identifying principles of brain function and computation, focused on using comparative approaches and exploiting unusual model systems (reptiles, cephalopods) to study sleep, texture perception and cerebral cortex evolution.

Gilles Laurent, PhD, DVM

Director

Max Planck Institute for Brain Research

http://www.brain.mpg.de/home/

 

4:00 PM

Location: T-739, HSB

 

host: Stan Froehner

Jan
25
Thu
2018
PBIO Seminar Series: Amy Bastian, PhD @ HSB G-328
Jan 25 @ 9:30 am – 10:30 am

 

Amy Bastian, Ph.D.
Professor of Neuroscience
Johns Hopkins University

 

Host: John Tuthill

 

May
10
Thu
2018
2018 Crill Lecture – J. Anthony Movshon @ HSB G-328
May 10 all-day

Time & Location TBA

J. Anthony Movshon, PhD

Professor, Department of Ophthalmology

Professor, Department of Neuroscience and Physiology