Physiology and Biophysics

Seminars

May
10
Thu
2018
2018 Crill Lecture – J. Anthony Movshon @ HSB T-639
May 10 @ 2:00 pm – 3:00 pm

“Elements of visual form perception”

J. Anthony Movshon, PhD

Professor, Department of Ophthalmology

Professor, Department of Neuroscience and Physiology

Thursday, May 10, 2018
2:00 p.m.
T-639 HSB

May
17
Thu
2018
PBIO Seminar Series: Brent Doiron, Ph.D. @ HSB G-328
May 17 @ 9:30 am – 10:30 am

New Cortex.  Who dis(inhibition)?

 

Brent Doiron, PhD
Professor
Department of Mathematics
University of Pittsburgh

host: Adrienne Fairhall

seminar abstract:

New Cortex.  Who dis(inhibition)?

 

It is now clear that the inhibitory circuitry within cortical networks is very complex, with multiple cell types interacting with one another and pyramidal neurons in complicated and cell specific ways.  The theoretical community has been slow to adapt to this new circuit reality, and much of our results are obtained from analysis of simpler recurrent excitatory-inhibitory circuits. Two often cited functional roles of inhibition is to: 1) stabilize the dynamics of recurrently coupled excitatory networks, and 2) enact gain control of excitatory neuron responses to a driving stimulus.  In classic excitatory-inhibitory networks mechanisms that place the network in a high gain state necessarily flirt with network instability.  We analyze how recurrent networks of pyramidal neurons (PN), parvalbumin-expressing (PV), somatostatin-expressing (SOM), and vasoactive intestinal polypeptide-expressing (VIP) interneurons compartmentalize stability and gain control through distinct inhibitory and disinhibitory pathways.  This permits a disassociation of stability and gain control in the circuit.  We further show how PC to SOM connections can be crucial in state dependent gain amplification with a simultaneous decrease of shared variability (noise correlations).  In sum, by expanding the complexity of inhibitory architecture cortical circuits can navigate distinct functional roles of inhibition through a “division of labor” with the inhibitory circuit.  This imparts a robustness to the functional operations of the circuit that is absent in the often fine-tuned reduced excitatory-inhibitory framework.

May
24
Thu
2018
PBIO Seminar Series: Ariel Rokem @ HSB G-328
May 24 @ 9:30 am – 10:30 am

seminar: T.B.A.

Ariel Rokem, PhD
Senior Data Scientist
eScience Institute, University of Washington

host: Fairhall

May
31
Thu
2018
PBIO Seminar Series: Nicholas Whitehead @ HSB G-328
May 31 @ 9:30 am – 10:30 am

Simvastatin: unexpected or logical therapy for muscular dystrophy?

Nicholas P Whitehead, Ph.D.

University of Washington

host: Stanley C. Froehner

Jun
7
Thu
2018
PBIO Seminar Series: Amy Bastian @ HSB G-328
Jun 7 @ 9:30 am – 10:30 am

Learning and Relearning Movement

Human motor learning depends on a suite of brain mechanisms that are driven by different signals and operate on timescales ranging from minutes to years. Understanding these processes requires identifying how new movement patterns are normally acquired, retained, and generalized, as well as the effects of distinct brain lesions. The lecture focuses on normal and abnormal motor learning and how we can use this information to improve rehabilitation for individuals with neurological damage

Amy Bastian, Ph.D.
Professor of Neuroscience
Johns Hopkins University

Host: John Tuthill

Oct
4
Thu
2018
PBIO seminar series: [no speaker scheduled]
Oct 4 @ 9:30 am – 10:30 am
Oct
11
Thu
2018
PBIO seminar series: [no speaker scheduled]
Oct 11 @ 9:30 am – 10:30 am
Oct
18
Thu
2018
PBIO seminar series: [no speaker scheduled]
Oct 18 @ 9:30 am – 10:30 am
Nov
1
Thu
2018
PBIO seminar series: Benedikt Grothe
Nov 1 @ 9:30 am – 10:30 am

Auditory Processing

Auditory neurons concerned with temporal processing are the most precise time analyzing units in the mammalian brain. Some auditory neurons exhibit time resolutions of only a few µs. We are interested in the neuronal mechanisms of temporal auditory processing and their evolution in mammals. In particular, our studies are concerned with the role of neural inhibition in temporal processing. Inhibition has been more or less neglected as a possible player in neuronal filtering of temporal cues. However, recent results from several groups indicate a link of age related hearing deficits in temporal processing, age related down-regulation of the inhibitory transmitters GABA and glycine, and the role of inhibition in temporal filtering as found in the bat and gerbil auditory brainstem. The analysis of temporal cues of sounds is important for two basic tasks: (1) sound localization and (2) sound recognition.

http://www.neuro.bio.lmu.de/members/systems_neuro_grothe/grothe_b/index.html

Nov
8
Thu
2018
PBIO seminar series: Ellen Lumpkin
Nov 8 @ 9:30 am – 10:30 am

 

Ellen Lumpkin

Columbia University

 

host: John Tuthill

Nov
15
Thu
2018
PBIO seminar series: [no speaker scheduled]
Nov 15 @ 9:30 am – 10:30 am
PBIO seminar series: [no speaker scheduled]
Nov 15 @ 9:30 am – 10:30 am
PBIO seminar series: [no speaker scheduled]
Nov 15 @ 9:30 am – 10:30 am
Nov
22
Thu
2018
PBIO seminar series: [no speaker scheduled]
Nov 22 @ 9:30 am – 10:30 am
Nov
29
Thu
2018
PBIO seminar series: Luke Rice @ HSB G-328
Nov 29 @ 9:30 am – 10:30 am
Dec
6
Thu
2018
PBIO seminar series: [no speaker scheduled]
Dec 6 @ 9:30 am – 10:30 am
Dec
13
Thu
2018
PBIO seminar series: [no speaker scheduled]
Dec 13 @ 9:30 am – 10:30 am
Dec
20
Thu
2018
PBIO seminar series: [no speaker scheduled]
Dec 20 @ 9:30 am – 10:30 am
Jan
3
Thu
2019
PBIO seminar series: [no speaker scheduled]
Jan 3 @ 9:30 am – 10:30 am
Jan
10
Thu
2019
PBIO seminar series: [no speaker scheduled]
Jan 10 @ 9:30 am – 10:30 am
Jan
17
Thu
2019
PBIO seminar series: [no speaker scheduled]
Jan 17 @ 9:30 am – 10:30 am