Physiology and Biophysics

Seminars

Feb
1
Thu
2018
Science in Medicine – Linda Wordeman @ D-209, HSB
Feb 1 @ 11:30 am – 12:30 pm
“Curious Intersection Between DNA Repair and Microtubule Dynamics” Linda Wordeman, Ph.D Professor Physiology & Biophysics, UW Dr. Linda Wordeman, Ph.D. uses high resolution live imaging to discover how changes in microtubule dynamics influence chromosome segregation and Chromosome INstability (CIN) in cancer cells. Dr. Wordeman will describe, mechanistically, how small changes in microtubule assembly dynamics promote CIN and reveal evidence for unexpected pathways, such as DNA damage repair, that may directly impact cellular mictrotubule dynamics.
Feb
5
Mon
2018
PBIO Seminar: Scott Linderman, PhD @ HSB G-328
Feb 5 @ 9:30 am – 10:30 am

Discovering Structure in Neural and Behavioral Data

Scott Linderman, PhD Department of Statistics Columbia University   Abstract: New recording technologies are transforming neuroscience, allowing us to precisely quantify neural activity, sensory stimuli, and natural behavior.  How can we discover simplifying structure in these high-dimensional data and relate these domains to one another? I will present my work on developing statistical tools and machine learning methods to answer this question.  With two examples, I will show how we can leverage prior knowledge and theories to build models that are flexible enough to capture complex data yet interpretable enough to provide new insight. Alongside these examples, I will discuss the Bayesian inference algorithms I have developed to fit such models at the scales required by modern neuroscience.  First, I will develop models to study global brain states and recurrent dynamics in the neural activity of C. elegans.  Then, I will show how similar ideas apply to data that, on the surface, seem very different: movies of freely behaving larval zebrafish.  In both cases, these models reveal how complex patterns may arise by switching between simple states, and how state changes may be influenced by internal and external factors.  These examples illustrate a framework for harnessing recent advances in machine learning, statistics, and neuroscience.  Prior knowledge and theory serve as the main ingredients for interpretable models, machine learning methods lend additional flexibility for complex data, and new statistical inference algorithms provide the means to fit these models and discover structure in neural and behavioral data. Host: Stanley C. Froehner  
Feb
15
Thu
2018
PBIO Seminar Series: Bernhard Flucher @ HSB G-328
Feb 15 @ 9:30 am – 10:30 am

How and why are the currents of CaV1.1 calicum channels curtailied in skeletal muscle?

The presentation will include structure-function studies on CaV1 channels and analyses of the role of the calcium current in muscle fiber type specification and neuro-muscular junction formation using various mouse models. Bernhard Flucher, PhD Professor Department of Physiology and Medical Physics Medizinische Universität Innsbruck host: Stan Froehner
Feb
22
Thu
2018
PBIO Seminar Series: [no speaker scheduled] @ HSB G-328
Feb 22 @ 9:30 am – 10:30 am
Mar
1
Thu
2018
PBIO Seminar Series: [no speaker scheduled] @ HSB G-328
Mar 1 @ 9:30 am – 10:30 am
Mar
8
Thu
2018
PBIO Seminar Series: [no speaker scheduled] @ HSB G-328
Mar 8 @ 9:30 am – 10:30 am
Mar
15
Thu
2018
PBIO Seminar Series: [no speaker scheduled] @ HSB G-328
Mar 15 @ 9:30 am – 10:30 am
Mar
22
Thu
2018
PBIO Seminar Series: [no speaker scheduled] @ HSB G-328
Mar 22 @ 9:30 am – 10:30 am
Mar
29
Thu
2018
PBIO Seminar Series: [no speaker scheduled] @ HSB G-328
Mar 29 @ 9:30 am – 10:30 am
Apr
5
Thu
2018
PBIO Seminar Series: [no speaker scheduled] @ HSB G-328
Apr 5 @ 9:30 am – 10:30 am
Apr
12
Thu
2018
PBIO Seminar Series: [no speaker scheduled] @ HSB G-328
Apr 12 @ 9:30 am – 10:30 am
Apr
19
Thu
2018
PBIO Seminar Series: [no speaker scheduled] @ HSB G-328
Apr 19 @ 9:30 am – 10:30 am
Apr
26
Thu
2018
Bertil Hille – Distinguished Science in Medicine @ Hogness Auditorium
Apr 26 @ 12:00 pm – 1:00 pm
Distinguished Science in Medicine Lecture Bertil Hille Thurs., April 26, 2018 NOON Hogness Auditorium.
May
3
Thu
2018
2018 Hille Lecture – Doris Tsao @ HSB T-747
May 3 @ 4:00 pm – 5:00 pm
Faces: a neural Rosetta stone Objects constitute the fundamental currency of the brain: they are things that we perceive, remember, and think about.  One of the most important objects for a primate is a face. Research on the macaque face patch system in recent years has given us a remarkable window into the detailed processes underlying object recognition. I will discuss recent findings from our lab elucidating the code for facial identity used by cells in face patches. I will then discuss how this code is used by downstream areas, as well as how the brain computes what constitutes an object in the first place. Doris Tsao Professor of Biology HHMI Investigator California Institute of Technology time: 4:00pm location: T-747, HSB host: Stan Froehner
May
10
Thu
2018
2018 Crill Lecture – J. Anthony Movshon @ HSB T-639
May 10 @ 2:00 pm – 3:00 pm
“Elements of visual form perception” J. Anthony Movshon, PhD

Professor, Department of Ophthalmology

Professor, Department of Neuroscience and Physiology

Thursday, May 10, 2018 2:00 p.m. T-639 HSB
May
17
Thu
2018
PBIO Seminar Series: Brent Doiron, Ph.D. @ HSB G-328
May 17 @ 9:30 am – 10:30 am

New Cortex.  Who dis(inhibition)?

  Brent Doiron, PhD Professor Department of Mathematics University of Pittsburgh host: Adrienne Fairhall seminar abstract: New Cortex.  Who dis(inhibition)?   It is now clear that the inhibitory circuitry within cortical networks is very complex, with multiple cell types interacting with one another and pyramidal neurons in complicated and cell specific ways.  The theoretical community has been slow to adapt to this new circuit reality, and much of our results are obtained from analysis of simpler recurrent excitatory-inhibitory circuits. Two often cited functional roles of inhibition is to: 1) stabilize the dynamics of recurrently coupled excitatory networks, and 2) enact gain control of excitatory neuron responses to a driving stimulus.  In classic excitatory-inhibitory networks mechanisms that place the network in a high gain state necessarily flirt with network instability.  We analyze how recurrent networks of pyramidal neurons (PN), parvalbumin-expressing (PV), somatostatin-expressing (SOM), and vasoactive intestinal polypeptide-expressing (VIP) interneurons compartmentalize stability and gain control through distinct inhibitory and disinhibitory pathways.  This permits a disassociation of stability and gain control in the circuit.  We further show how PC to SOM connections can be crucial in state dependent gain amplification with a simultaneous decrease of shared variability (noise correlations).  In sum, by expanding the complexity of inhibitory architecture cortical circuits can navigate distinct functional roles of inhibition through a “division of labor” with the inhibitory circuit.  This imparts a robustness to the functional operations of the circuit that is absent in the often fine-tuned reduced excitatory-inhibitory framework.
May
24
Thu
2018
PBIO Seminar Series: Ariel Rokem @ HSB G-328
May 24 @ 9:30 am – 10:30 am
seminar: T.B.A. Ariel Rokem, PhD Senior Data Scientist eScience Institute, University of Washington host: Fairhall
May
31
Thu
2018
PBIO Seminar Series: Nicholas Whitehead @ HSB G-328
May 31 @ 9:30 am – 10:30 am
Simvastatin: unexpected or logical therapy for muscular dystrophy? Nicholas P Whitehead, Ph.D. University of Washington host: Stanley C. Froehner
Jun
7
Thu
2018
PBIO Seminar Series: Amy Bastian @ HSB G-328
Jun 7 @ 9:30 am – 10:30 am

Learning and Relearning Movement

Human motor learning depends on a suite of brain mechanisms that are driven by different signals and operate on timescales ranging from minutes to years. Understanding these processes requires identifying how new movement patterns are normally acquired, retained, and generalized, as well as the effects of distinct brain lesions. The lecture focuses on normal and abnormal motor learning and how we can use this information to improve rehabilitation for individuals with neurological damage Amy Bastian, Ph.D. Professor of Neuroscience Johns Hopkins University Host: John Tuthill
Aug
8
Wed
2018
“Update on the management of acute ischemic stroke” – Presented by UW CME Neurology Lecture Series @ Harborview Medical Center
Aug 8 @ 12:00 pm – 1:00 pm
David L. Tirschwell, MD Attending, Neurology University of Washington
Aug
9
Thu
2018
“Three Things to Discuss on Parkinson’s Disease” – Presented by Department of Neurology Grand Rounds @ Health Sciences Building
Aug 9 @ 4:30 pm – 5:30 pm
Ali Samii, MD, Professor Department of Neurology Co-Director, Movement Disorder Fellowship University of Washington
Aug
13
Mon
2018
“The Role of RNA-Binding Protein, Muscleblind-Like 1, in Cardiac Wound Healing and Remodeling” – Doctoral Dissertation @ South Lake Union
Aug 13 @ 3:00 pm – 4:00 pm
Christina J. Jones Department of Pharmacology Advisor: Dr. Randall Moon
“Evolution of cognition and language: Perspectives from human and nonhuman primate neural systems” – Presented by Department of Physiology & Biophysics @ Health Sciences Building
Aug 13 @ 3:30 pm – 4:30 pm
Professor Christopher I. Petkov Laboratory of Comparative Neuropsychology Newcastle University, U.K.
Aug
16
Thu
2018
“Cortical Circuits for Sensory Processing and Behavior” – Presented by Department of Physiology & Biophysics @ Health Sciences Building
Aug 16 @ 10:00 am – 11:00 am
David Margolis, PhD Department of Cell Biology & Neuroscience Rutgers University New Brunswick, NJ
“Update on Spinal Cord Emergencies” – Presented by Department of Neurology Grand Rounds @ Health Sciences Building
Aug 16 @ 4:30 pm – 5:30 pm
Randall M. Chesnut, MD, FCCM, FACS, FAANS Integra Endowed Professor of Neurotrauma Department of Neurological Surgery and Orthopaedic Surgery University of Washington
Aug
20
Mon
2018
“Deciphering the Gene Regulatory Interactions Driving Immune Evasion in Cancer” – Faculty Candidate Seminar – Presented by Department of Immunology @ South Lake Union
Aug 20 @ 3:30 pm – 4:30 pm
Paola Betancur, Ph.D. Postdoctoral Fellow/Instructor Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
Aug
22
Wed
2018
“A Case of Progressive Weakness and Diplopia” – Presented by UW CME Neurology Lecture Series @ Harborview Medical Center
Aug 22 @ 12:00 pm – 1:00 pm
David Ivanick, MD Resident, Neurology University of Washington
Aug
23
Thu
2018
“Human pluripotent stem cell models of heart development and disease” – Presented by Institute for Stem Cell & Regenerative Medicine @ South Lake Union
Aug 23 @ 12:00 pm – 1:00 pm
David A. Elliott, PhD Tem Leader; Cardiac Regeneration Murdoch Children’s Research Institute
“Toxins and the Nervous System” – Presented by Department of Neurology Grand Rounds @ Health Sciences Building
Aug 23 @ 4:30 pm – 5:30 pm
Lucio G. Costa, Professor Department of Env. and Occ. Health Sciences University of Washington
Aug
24
Fri
2018
“Responsible Management of Data: Lessons from a Statewide Biobank” – 2018 Biomedical Research Integrity Program @ Health Sciences Building, Hogness Auditorium
Aug 24 @ 4:00 pm – 5:00 pm
Elizabeth Boyd, PhD Vice President for Research Administration Fred Hutchinson Cancer Research Center