Physiology and Biophysics


“Oh To Be Seventeen Again: IL-17 signaling in autoimmunity and host defense” – Presented by Department of Immunology @ South Lake Union
Oct 9 @ 3:30 pm – 4:30 pm

Sarah Gaffen, PhD
Gerald P. Rodnan Endowed Chair and Professor of
Rheumatology & Clinical Immunology
University of Pittsburgh

“Myosin Binding Protein-C: Stepping on both the gas and brake to regulate cardiac contractility” – Presented by Center for Cardiovascular Biology and Mitochrondria and Metabolism Center @ South Lake Union
Oct 10 @ 9:00 am – 10:00 am

David Warshaw, PhD, Professor and Chair
Molecular Physiology & Biophysics
University of Vermont

“Defects in mRNA translation and neurodegeneration” Presented by Department of Biochemistry @ Health Sciences Building
Oct 10 @ 10:30 am – 11:30 am

Susan Ackerman, Ph.D.
University of California
San Diego, California

“Evolution of Drift robustness: The curious case of ENA editing in Trypanosomes” – Presented by Division of Basic Sciences @ Fre Hutchinson Cancer Research Center
Oct 10 @ 12:00 pm – 1:00 pm

Chris Adami, Ph.D., Michigan State University
Departments of Microbiology and Molecular Genetics &
Physics and Astronomy

“Rewiring Genome Structure with Programmable CRISPR-Cas Tools to Physically Reposition Genes” – Presented by Department of Pharmacology @ Health Sciences Building
Oct 10 @ 2:30 pm – 3:30 pm

Jesse G. Zalatan, PhD, Assistant Professor
Department of Chemistry
University of Washington

Sensory Science – SLU Collaborative UW Medicine, Fred Hutchinson Research Center, Allen Institute
Oct 10 @ 4:00 pm – 5:00 pm

Thomas A. Reh, PhD, Professor, Biological Structure, UW
Jihong Bai, PhD, Associate Member, Basic Sciences Division, Fred Hutch
Severine Durand, PhD, Scientist II, Allen Institute for Brain Science

“Advocacy and the Internal Medicine Physician” – Presented by Department of Medicine Grand Rounds @ Health Sciences Building
Oct 12 @ 8:00 am – 9:00 am

Genevieve Pagalilauan, MD, Associate Professor
Department of Medicine, Division of General Internal Medicine
UW School of Medicine

“High spatiotemporal resolution, Three-dimension fluorescence imaging of biological samples in vivo” – Presented by Department of Physiology & Biophysics @ Health Sciences Building
Oct 12 @ 9:30 am – 10:30 am

Dr. Liangyi Chen, Professor
Laboratory of Cell Secretion and Metabolism
Institute of Molecular Medicine
Peking University, Beijing, China

PBIO Seminar Series: Liangyi Chen @ HSB G-328
Oct 12 @ 9:30 am – 10:30 am

High spatiotemporal resolution, three-dimension fluorescence imaging of biological samples in vivo

Dr. Liangyi Chen
Laboratory of Cell Secretion and Metabolism
Institute of Molecular Medicine,
Peking University, Beijing, China

Host: Bertil Hille

Abstract: I will give two stories. (i) One story describes unpublished ultrasensitive Hessian structured illumination microscopy that enables ultrafast and long-term super-resolution (SR) live-cell imaging. At a photon dose one order less than point-scanning microscopy, Hessian-SIM has achieved 88-nm and 188-Hz spatial-temporal resolution for live cells imaging and lasted thousands of images without artifacts. Operating at 1 Hz, Hessian-SIM enables hour-long, time-lapse SR imaging with mitigatable photobleaching, highlighting the possibility of achieving SR imaging with commonly used fluorophores for an unlimited period of time. (ii) The second story is our recent Nature Methods paper, our invention of the fast high-resolution miniature two-photon microscope for brain imaging in freely-behaving mice at the single-spine level. With a headpiece weighing 2.15 g and a new type of hollow-core photonic crystal
fiber to deliver 920-nm femtosecond laser pulses, the mini-microscope is capable of imaging commonly used biosensors at high spatiotemporal resolution (0.64 μm laterally and 3.35 μm axially, 40 Hz at 256 × 256 pixels). It compares favorably with benchtop two-photon microscopy and miniature wide-field fluorescence microscopy in the structural and functional imaging of Thy1-GFP- or GCaMP6f-labeled neurons. Further, we demonstrate its unique application and robustness with hour-long recording of neuronal activities down to the level of spines in mice experiencing vigorous body and head movements or engaging in social interaction.

“A modest change in regulation of NOD1 expression has a major impact on inflammation and gastric cancer” – Presented by Department of Immunology – IMMUN 550 Research-in-Progress (RIP) @ South Lake Union
Oct 12 @ 3:30 pm – 4:30 pm

Leah Rommereim, PhD
Postdoctoral Fellow in the Subramanian Lab
Department of Immunology

“BCAP promotes TLR-induced IFNa induction in pDC” – Presented by Department of Immunology – IMMUN 550 Research-in-Progress (RIP) @ South Lake Union
Oct 12 @ 3:30 pm – 4:30 pm

Talyn Chu, Graduate Student
Hamerman Lab
Department of Immunology, UW

“Screening for Inflammatory Neuropathies” – Presented by Department of Neurology Grand Rounds @ Health Sciences Building
Oct 12 @ 4:30 pm – 5:30 pm

Chafic Karam, M.D., Assistant Professor
Department of Neurology
Oregon Health & Science University

“COMPASS Trial: Insights into Aspirin and Rivaroxaban Combined Therapy” – Presented by Division of Cardiology Grand Rounds @ Health Sciences Building
Oct 13 @ 7:30 am – 8:30 am

Kelley Branch, MD, Msc, Associate Professor
Internal Medicine/Cardiology, UW

Jeff Probstfield, MD, Professor
Internal Medicine/Cardiology, UW

“Quantifying the Role that Terrestrial Ecosystems Play in Earth’s Climate” – Presented by Department of Atmospheric Sciences @ JHN 075
Oct 13 @ 3:30 pm – 4:30 pm

Professor Abigail Swann
UW Atmospheric Sciences & Biology

PBIO Seminar Series: Brian Kalmbach @ HSB G-328
Oct 26 @ 9:30 am – 10:30 am

“Of Mice and Men: Intrinsic Membrane Properties of Human Cortical Pyramidal Neurons”

Brian Kalmbach, Ph.D.

Allen Institute for Brain Science

host: Nikolai Dembrow

2017 Lamport Lecture – Gilles Laurent @ T-739 HSB
Nov 2 @ 4:00 pm – 5:00 pm

Evolution and brain computation

I will introduce our work towards identifying principles of brain function and computation, focused on using comparative approaches and exploiting unusual model systems (reptiles, cephalopods) to study sleep, texture perception and cerebral cortex evolution.

Gilles Laurent, PhD, DVM


Max Planck Institute for Brain Research


4:00 PM

Location: T-739, HSB


host: Stan Froehner

PBIO Seminar Series: Nikolai Dembrow @ HSB G-328
Dec 7 @ 9:30 am – 10:30 am

Title: TBA

Nikolai Dembrow, PhD

host: Stan Froehner

PBIO Seminar Series: Amy Bastian, PhD @ HSB G-328
Jan 25 @ 9:30 am – 10:30 am


Amy Bastian, Ph.D.
Professor of Neuroscience
Johns Hopkins University


Host: John Tuthill


2018 Crill Lecture – J. Anthony Movshon @ HSB G-328
May 10 all-day

Time & Location TBA

J. Anthony Movshon, PhD

Professor, Department of Ophthalmology

Professor, Department of Neuroscience and Physiology