Physiology and Biophysics

Seminars

Apr
6
Thu
2017
2017 Hille Lecture – Thomas Schwarz @ Foege Auditorium
Apr 6 @ 4:00 pm – 5:00 pm
Moving and Removing Axonal Mitochondria Thomas L. Schwarz, PhD Professor Neurology F.M. Kirby Center for Neurobiology Children’s Hospital, Boston and Dept. of Neurobiology, Harvard Medical School Time: 4:00PM Location: Foege Auditorium, GNOM S060 seminar abstract: Mitochondria are dynamic organelles.  In every cell they move and undergo fission and fusion.  Their distribution and associations with the cytoskeleton change in response to many signals, including the mitotic cell cycle.  In addition, because neurons look like no other cell in the organism, with axons of up to a meter in humans, mitochondrial motility is particularly crucial to the survival of the neuron. The neuron also needs to clear away damaged mitochondria efficiently wherever in the cell they may arise.  Not surprisingly then, defects in the transport machinery of neurons and in their mechanisms for removing damaged mitochondria have been linked to several neurodegenerative diseases, including ALS and Parkinson’s disease.  This talk will present the evidence for a motor/adaptor complex that is responsible for and regulates the movement of mitochondria and will discuss how that movement is regulated by the cell cycle, Ca++, and glucose.  We will look at the operation of two proteins PINK1 and Parkin that are mutated in forms of Parkinson’s disease and examine how these proteins operate in axons to clear away damaged mitochondria that might otherwise compromise the health of the cell.  Particularly in the case of mitophagy, we will consider the special challenges posed for neurons by their extended geometry and the difficulty of having a PINK1-dependent pathway operating far from the soma.  
Jun
20
Tue
2017
2017 Crill Lecture – William Bialek @ D-209 HSB
Jun 20 @ 4:00 pm – 5:00 pm
Thinking about a thousand neurons William Bialek John Archibald Wheeler/Battelle Professor in Physics Princeton University
Sep
28
Thu
2017
PBIO Seminar Series: [no speaker scheduled] @ HSB G-328
Sep 28 @ 9:30 am – 10:30 am
Oct
5
Thu
2017
PBIO Seminar Series: [no speaker scheduled] @ HSB G-328
Oct 5 @ 9:30 am – 10:30 am
Oct
19
Thu
2017
PBIO Seminar Series: [no speaker scheduled] @ HSB G-328
Oct 19 @ 9:30 am – 10:30 am
Nov
2
Thu
2017
2017 Lamport Lecture – Gilles Laurent @ T-739 HSB
Nov 2 @ 4:00 pm – 5:00 pm

Evolution and brain computation

I will introduce our work towards identifying principles of brain function and computation, focused on using comparative approaches and exploiting unusual model systems (reptiles, cephalopods) to study sleep, texture perception and cerebral cortex evolution. Gilles Laurent, PhD, DVM Director Max Planck Institute for Brain Research http://www.brain.mpg.de/home/   4:00 PM Location: T-739, HSB   host: Stan Froehner
Nov
9
Thu
2017
PBIO Seminar Series: [no speaker scheduled] @ HSB G-328
Nov 9 @ 9:30 am – 10:30 am
Nov
16
Thu
2017
PBIO Seminar Series: [no speaker scheduled] @ HSB G-328
Nov 16 @ 9:30 am – 10:30 am
Nov
30
Thu
2017
PBIO Seminar Series: [no speaker scheduled] @ HSB G-328
Nov 30 @ 9:30 am – 10:30 am
Dec
14
Thu
2017
PBIO Seminar Series: [no speaker scheduled] @ HSB G-328
Dec 14 @ 9:30 am – 10:30 am
Dec
21
Thu
2017
PBIO Seminar Series: [no speaker scheduled] @ HSB G-328
Dec 21 @ 9:30 am – 10:30 am
Jan
4
Thu
2018
PBIO Seminar Series: save for CompNeuroSearch @ HSB G-328
Jan 4 @ 9:30 am – 10:30 am
Save for Computational Neuroscience Search
Feb
22
Thu
2018
PBIO Seminar Series: [no speaker scheduled] @ HSB G-328
Feb 22 @ 9:30 am – 10:30 am
Mar
1
Thu
2018
PBIO Seminar Series: [no speaker scheduled] @ HSB G-328
Mar 1 @ 9:30 am – 10:30 am
Mar
8
Thu
2018
PBIO Seminar Series: [no speaker scheduled] @ HSB G-328
Mar 8 @ 9:30 am – 10:30 am
Mar
15
Thu
2018
PBIO Seminar Series: [no speaker scheduled] @ HSB G-328
Mar 15 @ 9:30 am – 10:30 am
Mar
22
Thu
2018
PBIO Seminar Series: [no speaker scheduled] @ HSB G-328
Mar 22 @ 9:30 am – 10:30 am
Mar
29
Thu
2018
PBIO Seminar Series: [no speaker scheduled] @ HSB G-328
Mar 29 @ 9:30 am – 10:30 am
Apr
5
Thu
2018
PBIO Seminar Series: [no speaker scheduled] @ HSB G-328
Apr 5 @ 9:30 am – 10:30 am
Apr
12
Thu
2018
PBIO Seminar Series: [no speaker scheduled] @ HSB G-328
Apr 12 @ 9:30 am – 10:30 am
Apr
19
Thu
2018
PBIO Seminar Series: [no speaker scheduled] @ HSB G-328
Apr 19 @ 9:30 am – 10:30 am
Apr
26
Thu
2018
Bertil Hille – Distinguished Science in Medicine @ Hogness Auditorium
Apr 26 @ 12:00 pm – 1:00 pm
Distinguished Science in Medicine Lecture Bertil Hille Thurs., April 26, 2018 NOON Hogness Auditorium.
May
3
Thu
2018
2018 Hille Lecture – Doris Tsao @ HSB T-747
May 3 @ 4:00 pm – 5:00 pm
Faces: a neural Rosetta stone Objects constitute the fundamental currency of the brain: they are things that we perceive, remember, and think about.  One of the most important objects for a primate is a face. Research on the macaque face patch system in recent years has given us a remarkable window into the detailed processes underlying object recognition. I will discuss recent findings from our lab elucidating the code for facial identity used by cells in face patches. I will then discuss how this code is used by downstream areas, as well as how the brain computes what constitutes an object in the first place. Doris Tsao Professor of Biology HHMI Investigator California Institute of Technology time: 4:00pm location: T-747, HSB host: Stan Froehner
Oct
11
Thu
2018
PBIO seminar series: [no speaker scheduled]
Oct 11 @ 9:30 am – 10:30 am
Oct
18
Thu
2018
PBIO seminar series: [no speaker scheduled]
Oct 18 @ 9:30 am – 10:30 am
Oct
25
Thu
2018
PBIO seminar series: [no speaker scheduled]
Oct 25 @ 9:30 am – 10:30 am
Nov
1
Thu
2018
PBIO seminar series: [no speaker scheduled] @ G-328 H.S.B.
Nov 1 @ 9:30 am – 10:30 am
Dec
20
Thu
2018
PBIO seminar series: [no speaker scheduled]
Dec 20 @ 9:30 am – 10:30 am
Jan
3
Thu
2019
PBIO seminar series: [no speaker scheduled]
Jan 3 @ 9:30 am – 10:30 am
Jan
10
Thu
2019
PBIO seminar series: [no speaker scheduled]
Jan 10 @ 9:30 am – 10:30 am