2018 Lamport Lecture
Cytoplasmic Dynein and Kinesins in Brain Development and Autophagy
Microtubule Motor Proteins Are Involved in a Wide Range of cellular activities. Recent work in our lab has involved the role of the motor proteins in neuronal migration and neurogenesis in the developing brain. We have worked out mechanisms by which cytoplasmic dynein, its regulators Nde1 and Ndel1, and LIS1 and the kinesin Kif1a contribute to these functions as well as brain developmental disease. We have also found a new role for the dynein adaptor protein RILP as a master regulator of mTOR-dependent autophagy in neurons.
Professor of Pathology & Cell Biology
location: HSB, T-639
host: Stanley C. Froehner
Auditory neurons concerned with temporal processing are the most precise time analyzing units in the mammalian brain. Some auditory neurons exhibit time resolutions of only a few µs. We are interested in the neuronal mechanisms of temporal auditory processing and their evolution in mammals. In particular, our studies are concerned with the role of neural inhibition in temporal processing. Inhibition has been more or less neglected as a possible player in neuronal filtering of temporal cues. However, recent results from several groups indicate a link of age related hearing deficits in temporal processing, age related down-regulation of the inhibitory transmitters GABA and glycine, and the role of inhibition in temporal filtering as found in the bat and gerbil auditory brainstem. The analysis of temporal cues of sounds is important for two basic tasks: (1) sound localization and (2) sound recognition.
host: John Tuthill
Correlated spike time variability, population coding, and synchrony in the early visual system.
host: Adrienne Fairhall
In response to repeated presentation of the same stimulus, many visual neurons produce a variable number of spikes. This variability in spike count can be independent, correlated, or anti-correlated between pairs of neurons, and the implications of such correlations on sensory encoding have been extensively explored. In addition, spikes can also occur at variable times within the response (i.e., jitter, or spike time variability). While the magnitude of correlated spike count variability in spike count has been well-studied, the magnitude and sign of correlations in jitter, and any potential implications for visual coding, are not known. In this talk I will present measurements, using high-density electrophysiology (Neuropixels), of correlated jitter within small populations of 20-200 simultaneously recorded neurons across lateral geniculate nucleus and primary visual cortex. I will further discuss proposed mechanisms of correlated jitter and implications for potential and observed synchrony in visual cortical population responses.