Physiology and Biophysics

Seminars

Sep
25
Tue
2018
2018 Lamport Lecture – Richard Vallee @ HSB T-639
Sep 25 @ 4:00 pm – 5:00 pm

2018 Lamport Lecture

Cytoplasmic Dynein and Kinesins in Brain Development and Autophagy

Microtubule Motor Proteins Are Involved in a Wide Range of cellular activities.  Recent work in our lab has involved the role of the motor proteins in neuronal migration and neurogenesis in the developing brain.  We have worked out mechanisms by which cytoplasmic dynein, its regulators Nde1 and Ndel1, and LIS1  and the kinesin Kif1a contribute to these functions as well as brain developmental disease. We have also found a new role for the dynein adaptor protein RILP as a master regulator of mTOR-dependent autophagy in neurons.

Richard Vallee
Professor of Pathology & Cell Biology
Columbia University

time: 4:00pm
location: HSB, T-639

host: Stanley C. Froehner