Physiology and Biophysics

Seminars

May
10
Thu
2018
“Heart Failure: The Past, the Present, and the Future” MURRAY LECTURE – Presented by Department of Medicine Grand Rounds @ Health Sciences Building
May 10 @ 8:00 am – 9:00 am

Eugene Braunwald, M.D.
Distinguished Hersey Professor of Medicine, Harvard Medical School
Founding Chairman, TIMI Study Group, Brigham and Women’s Hospital

“Elements of visual form perception” – 17th Annual Wayne E. Crill Graduate Research Lecture Presented by Department of Physiology & Biophysics @ Health Sciences Building
May 10 @ 2:00 pm – 3:00 pm

J. Anthony Movshon, Ph.D.
Professor of Neural Science and Psychology
Center for Neural Science
New York University

2018 Crill Lecture – J. Anthony Movshon @ HSB T-639
May 10 @ 2:00 pm – 3:00 pm

“Elements of visual form perception”

J. Anthony Movshon, PhD

Professor, Department of Ophthalmology

Professor, Department of Neuroscience and Physiology

Thursday, May 10, 2018
2:00 p.m.
T-639 HSB

“Slowing the Ticking Clock: Quantitating “Quality of Life” with Age” – Presented by Nathan Shock Center of Excellence in the Basic Biology of Aging @ Health Sciences Building
May 10 @ 2:30 pm – 3:30 pm

Coleen Murphy, Ph.D., Professor
Molecular Biology, and the Lewis-Sigler Institute for
Integrative Genomics, Princeton University

“Using Applied Mathematics to Cure Viral Infections” – Presented by Department of Applied Mathematics – Boeing Distinguished Colloquia @ Smith Hall
May 10 @ 4:00 pm – 5:00 pm

Alan Perelson
Los Alamos National Lab

May
11
Fri
2018
“Diagnosing hearing difficulties among the “normal” hearing” – Presented by Communications Sciences (SHACS) @ Eagleson Hall
May 11 @ 3:30 pm – 4:30 pm

Ward R. Drennan, PhD, Researcher
Virginia Merrill Bloedel Hearing Research Center
University of Washington

May
14
Mon
2018
Enteroviruses 71 Emergence, Infection, and Innate Immunity – Presented by Center for Innate Immunity and Immune Disease @ South Lake Union
May 14 @ 10:00 am – 12:00 pm

Shin-Ru Shih, Ph.D., Director/Professor
Research Center for Emerging Viral Infections
Chang Gung University, Taiwan

Enteroviruses 71 Emergence, Infection, and Innate Immunity – Presented by Center for Innate Immunity and Immune Disease @ South Lake Union
May 14 @ 10:00 am – 12:00 pm

Rei-Lin Kuo, Ph.D., Associate Professor
Research Center for Emerging Viral Infections & Department of Medical
Biotechnology and Laboratory Science, Chang Gung University, Taiwan

“Models of Mechanotransduction in Cardiovscular Disease: From Organs to Molecules” – Bioengineering Cardiovascular Training Grant (BCTG) Symposium 2018 @ South Lake Union
May 14 @ 11:00 am – 6:00 pm

Keynote Speaker: 11:00 a.m. – Mohammad R.K. Mofrad, PhD
Departments of Bioengineering and Mechanical Engineering
University of California at Berkeley

“How and Why to Scan ALL the Fishes” – Presented by Department of Oral Health Sciences @ Friday Harbor Laboratories
May 14 @ 12:30 pm – 1:30 pm

Adam Summers, PhD, Professor
Biology – Friday Harbor Laboratories
University of Washington

“Understanding the ‘Fatal Attraction’ to Sugar: Moving from Systems to Genes” – Presented by Graduate Program in Neuroscience @ Health Sciences Building
May 14 @ 3:30 pm – 4:30 pm

Dianne F. Lattemann, Ph.D.
Senior Research Career Scientist, VA Sound Health Care System
Research Professor, University of Washington

May
15
Tue
2018
“Muscle Myosins: Isoforms, Mutations and Myopathies” – Presented by Center for Cardiovascular Biology and Mitochondria and Metabolism Center @ South Lake Union
May 15 @ 9:00 am – 10:00 am

Michael Geeves, PhD
Professor of Physical Biochemistry
School of Bioscience, University of Kent, UK

“From antibody-to-vaccine: Structure-based vaccine design for paramyxoviruses and HIV-1” – Presented by Department of Biochemistry @ Health Sciences Building
May 15 @ 10:30 am – 11:30 am

Peter Kwong, Ph.D.
NIH/VRC

“Defects in mRNA translation and neurodegeneration” – Presented by Division of Basic Sciences @ Fred Hutchinson Cancer Research Center
May 15 @ 12:00 pm – 1:00 pm

Susan Ackerman, Ph.D., HHMI Investigator
University of California, San Diego
Department of Cell and Molecular Medicine

“Folded viral RNAs that sense and manipulate the host cell Machinery” – Presented by Department of Microbiology @ Health Sciences Building
May 15 @ 4:00 pm – 5:00 pm

Jeffrey S. Kieft, Ph.D., Professor and Vice Chair
Department of Biochemistry and Molecular Genetics
Director, Structural Biology and Biophysics Core Facilities
University of Colorado School of Medicine

May
16
Wed
2018
Epilepsy: “TBD” – Presented by Department of Neurology Lecture Series @ Harborview Medical Center
May 16 @ 12:00 pm – 1:00 pm

Dr. John Miller

“What the mouse’s eyes tells the mouse’s brain and who is listening” – Presented by Department of Biological Structure @ Healh Sciences Building
May 16 @ 1:00 pm – 2:00 pm

Thomas Euler, CIN-Professor for Ophthalmic Research
Werner Reichardt Centre for Integrative Neuroscience
Institute for Ophthalmic Research
University of Tubingen, Germany

May
17
Thu
2018
“The EHR in 2018: Current Status and Future, Locally and Nationally” – Presented by Department of Medicine Grand Rounds @ Health Sciences Building
May 17 @ 8:00 am – 9:00 am

Thomas Payne, MD, FACP, Professor of Medicine
Adjunct Professor, Health Services and
Biomedical Informatics & Med Education, UW
Medical Director, Information Technology Services, UW Medicine

“New Cortex. Who dis(inhibition)?” – Presented by Department of Physiology & Biophysics Lecture Series @ Health Sciences Building
May 17 @ 9:30 am – 10:30 am

Brent Doiron, Ph.D., Professor
Department of Mathematics
University of Pittsburgh

PBIO Seminar Series: Brent Doiron, Ph.D. @ HSB G-328
May 17 @ 9:30 am – 10:30 am

New Cortex.  Who dis(inhibition)?

 

Brent Doiron, PhD
Professor
Department of Mathematics
University of Pittsburgh

host: Adrienne Fairhall

seminar abstract:

New Cortex.  Who dis(inhibition)?

 

It is now clear that the inhibitory circuitry within cortical networks is very complex, with multiple cell types interacting with one another and pyramidal neurons in complicated and cell specific ways.  The theoretical community has been slow to adapt to this new circuit reality, and much of our results are obtained from analysis of simpler recurrent excitatory-inhibitory circuits. Two often cited functional roles of inhibition is to: 1) stabilize the dynamics of recurrently coupled excitatory networks, and 2) enact gain control of excitatory neuron responses to a driving stimulus.  In classic excitatory-inhibitory networks mechanisms that place the network in a high gain state necessarily flirt with network instability.  We analyze how recurrent networks of pyramidal neurons (PN), parvalbumin-expressing (PV), somatostatin-expressing (SOM), and vasoactive intestinal polypeptide-expressing (VIP) interneurons compartmentalize stability and gain control through distinct inhibitory and disinhibitory pathways.  This permits a disassociation of stability and gain control in the circuit.  We further show how PC to SOM connections can be crucial in state dependent gain amplification with a simultaneous decrease of shared variability (noise correlations).  In sum, by expanding the complexity of inhibitory architecture cortical circuits can navigate distinct functional roles of inhibition through a “division of labor” with the inhibitory circuit.  This imparts a robustness to the functional operations of the circuit that is absent in the often fine-tuned reduced excitatory-inhibitory framework.

“The Story of HbA1c: Is it Still the Best Marker for Optimal Glycemic Control?” – Presented by Diabetes and Metabolism Seminar Series @ South Lake Union
May 17 @ 3:00 pm – 4:00 pm

Neda Rasouli, MD – Candidate for VA Section Head,
Metabolism, Endocrinology and Nutrition
Professor of Medicine, and Pharmacy
Director, CU Diabetes and Endocrinology Clinical Trial Program
Division of Endocrinology, Metabolism and Diabetes
University of Colorado

May
18
Fri
2018
“Regulating DNA replication and Mutagenesis in Bacillus subtilis” – Dissertation Defense @ Foege Auditorium
May 18 @ 1:00 pm – 2:00 pm

Ariana Samadpour
Department of Microbiology
Merrikh Lab

May
22
Tue
2018
“Diabetes-Accelerated Atherosclerosis – Potential New Treatment Strategies based on Insights from Mouse Models” – Presented by The Center for Cardiovascular Biology and the Mitochondria and Metabolism Center – Breakfast Club @ South Lake Union
May 22 @ 9:00 am – 10:00 am

Karin Bornfeldt, PhD, Professor of Medicine and Pathology
Director, Diabetes Complications Program
Division of Metabolism, Endocrinology and Nutrition
University of Washington

“Protein Folding as an allosteric strategy: the yin and yang of chaperone-mediated clinic activation” – The 13th Annual Milton Gordon Memorial Lecture – Presented ;by Department of Biochemistry Graduate Students @ Health Sciences Building
May 22 @ 10:30 am – 11:30 am

David Agard, Ph.D., HHMI Investigator
Professor, Departments Biochemistry/Biophysics and
Pharmaceutical Chemistry, UCSF; Scientific Director,
Institute for Bioengineering, Biotechnology,
Quantitative Biomedical Research
UCSF/UC-Berkeley/UC- Santa Cruz

“From metabolic to ecological networks in microbial communities” – Presented by Division of Basic Sciences @ Fred Hutchinson Cancer Research Center
May 22 @ 12:00 pm – 1:00 pm

Daniel Segre, Ph.D.
Boston University
Department of Biology

“Identification of G protein-coupled receptor macromolecular complexes: novel interfaces for drug discovery?” @ Foege Auditorium, Genome Sciences Building
May 22 @ 2:30 pm – 3:30 pm

Chris Hague, PhD, Associate Professor
Department of Pharmacology
University of Washington

Advancing genomic and screening technologies for the life sciences” – Presented by Department of Microbiology @ Health Sciences Building
May 22 @ 4:00 pm – 5:00 pm

Paul C. Blainey, Ph.D.
Associate Professor of Biological Engineering at MIT
Core Member of the Broad Institute of MIT and Harvard

May
23
Wed
2018
“TheRole of Glial Signaling in Energy Balance and Glucose Homeostasis” – Presented by Diabetes Research Center – Diabetes and Metabolism Seminar Series @ South Lake Union
May 23 @ 3:00 pm – 4:00 pm

Joshua Thaler, MD, PhD, Associate Professor of Medicine
Division of Endocrinology, Metabolism and Diabetes, UW
Candidate for VA Section Head, Metabolism,
Endocrinology and Nutrition

May
24
Thu
2018
“Performance-enhancing drugs: passport to play?” – Presented by Department of Medicine Grand Rounds @ Health Sciences Building
May 24 @ 8:00 am – 9:00 am

Bradley D. Anawalt, MD
Chief of Medicine, UWMC
Professor and Vice Chair, Dept. of Medicine
University of Washington

“Challenges and opportunities for computational neuroscience in the era of brain observatories” – Presented by Department of Physiology & Biophysics Seminar Series @ Health Sciences Building
May 24 @ 9:30 am – 10:30 am

Ariel Rokem, PhD., Senior Data Scientist
eScience Institute
University of Washington