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Kelly, Edward
J. - Acting Assistant Professor
Recent Publications:
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Perez HD, Kelly
E, Chenoweth D & Elfman F. Identification of the C5a des-Arg
cochemotaxin. Homology with vitamin D-binding protein (Gc globulin).
Journal of Clinical Investigation 82: 360-363, 1988.
- Perez HD, Kelly
E & Elfman F. Identification of the C5a des-Arg cochemotaxin.
Transactions of the Association of American Physicians 101:
242-249, 1988.
- Lobo E, Elfman
F, Kelly E & Perez HD. Effect of phorbol myristate acetate
on processing of formyl peptide receptors by human neutrophils.
Biochimica et Biophysica Acta 1055: 193-196, 1990.
- Perez HD, Kelly
E, Elfman F, Armitage G & Winkler J. Defective polymorphonuclear
leukocyte formyl peptide receptor(s) in juvenile periodontitis.
Journal of Clinical Investigation 87: 971-976, 1991.
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Perez HD, Kelly
E& Holmes R. Regulation of formyl peptide receptor expression
and its mRNA levels during differentiation of HL-60 cells. Journal
of Biological Chemistry 267: 358-363, 1992.
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Perez HD, Holmes
R, Kelly E, McClary J & Andrews WH. Cloning of a
cDNA encoding a receptor related to the formyl peptide receptor of
human neutrophils. Gene 118: 303-304, 1992.
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Perez HD, Holmes
R, Kelly E, McClary J, Chou Q & Andrews WH. Cloning of the
gene coding for a human receptor for formyl peptides. Characterization
of a promoter region and evidence for polymorphic expression.
Biochemistry 31: 11595-11599, 1992.
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Masters BA, Kelly
EJ, Quaife CJ, Brinster RL & Palmiter RD. Targeted disruption
of metallothionein I and II genes increases sensitivity to cadmium.
Proceedings of the National Academy of Sciences USA 91: 584-588,
1994.
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Quaife CJ, Findley
SD, Erickson JC, Froelick GJ, Kelly EJ, Zambrowicz BP & Palmiter
RD. Induction of a new metallothionein isoform (MT-IV) occurs
during differentiation of stratified squamous epithelia. Biochemistry
33: 7250-7259, 1994.
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Masters BA, Quaife
CJ, Erickson JC, Kelly EJ, Froelick GJ, Zambrowicz BP, Brinster RL
& Palmiter RD. Metallothionein III is expressed in neurons
that sequester zinc in synaptic vesicles. Journal of Neuroscience
14: 5844-5857, 1994.
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Erickson JC, Masters
BA, Kelly EJ, Brinster RL & Palmiter RD. Expression of human
metallothionein-III in transgenic mice. Neurochemistry International
27: 35-41, 1995.
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Kelly EJ, Quaife
CJ, Froelick GJ & Palmiter RD. Metallothionein-I and -II
protect mice against zinc deficiency and zinc toxicity. Journal
of Nutrition 126: 1782-1793, 1996.
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Kelly, EJ &
Palmiter, RD. A murine model of Menkes disease reveals a physiological
function of metallothionein. Nature Genetics 13: 219-222,
1996.
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Kelly, EJ &
Palmiter, RD. A pair of adjacent glucocorticoid response elements
regulate expression of two mouse metallothionein genes. Proceedings
of the National Academy of Sciences USA 94: 10045-10050, 1997.
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Quaife, CJ, Kelly,
EJ, Masters, BM, Brinster, RL & Palmiter, RD. Ectopic expression
of metallothionein-III causes pancreatic acinar cell necrosis in transgenic
mice. Toxicology and Applied Pharmacology 148: 148-157,
1998.
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Payne, AS, Kelly,
EJ & Gitlin, JD. Functional expression of the Wilson disease
protein reveals mislocalization and impaired copper-dependent trafficking
of the common H1069Q mutation. Proceedings of the National
Academy of Sciences USA 95:10854-10859, 1998.
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Tonge, RP, Kelly,
EJ, Bruschi, SA, Kalhorn, T, Eaton, DL, Nebert, DW & Nelson SD.
Role of CYP1A2 in the hepatotoxicity of acetaminophen: investigations
using Cyp1a2 null mice. Toxicology and Applied Pharmacology
153: 102-108, 1998.
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Wang, C, Bammler,
TK, Guo, Y, Kelly, EJ & Eaton, DL. Mu-class GSTs are responsible
for aflatoxin B(1)-8,9-epoxide-conjugating activity in the nonhuman
primate Macaca fascicularis liver. Toxicological Sciences
56: 26-36, 2000.
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Cheesman, MJ,
Kneller, MB, Kelly, EJ, Thompson, SJ, Yeung, CK, Eaton, DL & Rettie,
AE. Purification and characterization of hexahistidine-tagged
cyclohexanone monooxygenase expressed in Saccharomyces cerevisiae
and Escherichia coli. Protein Expression and Purification
21: 81-86, 2001.
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Eaton, DL, Bammler,
TK & Kelly, EJ. Interindividual differences in response
to chemoprotection against aflatoxin-induced hepatocarcinogenesis:
implications for human biotransformation enzyme polymorphisms.
Advances in Experimental Medicine and Biology 500:559-576, 2001.
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Kelly, EJ, Erickson,
KE, Sengstag, C & Eaton, DL. Expression of human microsomal
epoxide hydrolase in Saccharomyces cerevisiae reveals a functional
role in aflatoxin B1 detoxification. Toxicological Sciences
65: 35-42, 2002.
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McConnachie, LA,
Bodor, M, Philips, B., Kelly, EJ, Shen, DD & Ho, RJY. An
RT-PCR-based strategy to estimate full-length CYP2D6 mRNA copy number.
Genetic Testing 8: 313-318, 2004.
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Bodor, M,
Kelly, EJ, & Ho, RJY. Characterization of the Human MDR1
Gene. American Association of Pharmaceutical Scientists
Journal 7: E1-E5, 2005.
- Salama, NN, Kelly,
EJ, Bui, T & Ho, RJY. The impact of pharmacologic and genetic
knockout of P-glycoprotein on nelfinavir levels in the brain and other
tissues in mice. Journal Pharmaceutical Sciences 94: 1216-1225.
2005.
- Redman, AR, Zheng, J, Shamsi SA, Kelly EJ, Ho RJY. Ritchie, DM, & Hon, YY, 2008. Variant CYP2C9 Alleles and Warfarin concentrations in Patients Receiving low vs. Average Dose Warfarin Therapy. Clin Appl Thromb Hemost. 14(1):29-37.
- Rettie, AR & Kelly, EJ. The CYP4 family, In: Cytochrome P450: Role in the Metabolism and Toxicity of Drugs and Other Xenobiotics, C Ioannides ed., Royal Society of Chemistry Publishing. (in press)
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