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Ho, Rodney J. Y. - Professor
Selected Publications:
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Bethune, C.R.,
Bernards, C.M., Bui-Nguyen. T., Shen, D.D., and Ho, R.J. The role
of drug-lipid interactions on the disposition of liposome-formulated
opioid analgesics in vitro and in vivo. Anesth Analg 2001, 93(4):928-33.
Lian, T. and Ho, R.J.Y. Recent trend and progress in liposome drug delivery systems; an invited minireview. Journal of Pharmaceutical Sciences 2001, 90:667-680. Yang, Z., Woodahl, E.L., Wang, X.Y., Bui, T., Shen, D.D., and Ho R.J. Semi-quantitative RT-PCR method to estimate full-length mRNA levels of the multidrug resistance gene. BioTechniques 2002, 33:196-203. Kinman, L., Larsen, K., Bui, T., Brodie, S., Tsai, C.C., Schmidt, A., Anderson, D., Morton, W., Hu, S-L and Ho, R.J.Y. Lipid-drug association enhanced HIV protease inhibitor indinavir localization in lymphoid tissues and viral load reduction: A proof of concept study in HIV infected macaques, J. Acquired Immunodeficiency Syndrome 2003, Dec 1;34(4):387-97. Lian, T. and Ho, R.J.Y. Design and characterization of a novel lipid-DNA complex that resists serum-induced destabilization. J Pharmaceutical Sciences 2003, Dec; 92(12):2373-85. Ho, R.J.Y., and Gibaldi, M. "Biotechnology and Biopharmaceuticals: Transforming proteins and genes into drugs," John Wiley and Sons, N.Y., June 2003., Kinman LM, Worlein JM, Leigh J, Bielefeldt-Ohmann H, Anderson DM, Hu SL, Morton WR, Anderson BD, Ho RJ. HIV in central nervous system and behavioral development: an HIV-2287 macaque model of AIDS. AIDS. 2004 Jul 2;18(10):1363-70. Yang Z, Horn M, Wang J, Shen DD, Ho RJ. Development and characterization of a recombinant Madin-Darby canime kidney cell line that expresses rat multidrug resistance-associated protein 1(rMRP1). AAPS PharmSci. 2004, Mar 09;8(1):E8. McConnachie L, Bodor M, Kowdley K, Levy A, Tung B, Thummel K, Phillips B, Bajpai M, Chi V, Esmay JD, Shen DD, Ho RJ. Human liver cytochrome P450 2D6 genotype, full-length messenger ribonucleic acid, and activity assessed with a novel cytochrome P450 2D6 substrate. Clin Pharmacol Ther. 2004, Apr;75(4):282-97. McConnachie LA, Bodor M, Phillips B, Kelly EJ, Shen DD, Ho RJ. An RT-PCR-based strategy to estimate full-length CYP2D6 mRNA copy number. Genet Test. 2004 Fall;8(3):313-8. Woodahl EL, Yang Z, Bui T, Shen DD, Ho RJ. Multidrug resistance gene-1(MDR1) G1199A polymorphism alters efflux transport activity of P-glycoprotein. J Pharmacol Exp Ther. 2004 Sept;310(3):1199-207. Woodahl, E., and Ho, R. J.Y. The role of MDR1 genetic polymorphisms in inter-individual variability in p-glycoprotein expression and function. Current Drug Metabolism 2004, Feb;5(1):11-9. Woodahl, EL, Yang, Z, Bui, T, Shen, DD, and Ho, RJY. 2005. MDR1 G1199A polymorphism alters permeability of HIV protease inhibitors across polarized epithelial cells. AIDS, 2005 Oct 14;19(15):1617-25. Bodor M, Kelly EJ, Ho RJ. Characterization of the human MDR1 gene. AAPS Journal 2005 Feb 16;7(1):E1-5. Salama NN, Kelly EJ, Bui T, Ho RJ. The impact of pharmacologic and genetic knockout of P-glycoprotein on nelfinavir levels in the brain and other tissues in mice.J Pharmaceutical Science 2005 Jun;94(6):1216-25. Kinman L, Bui T, Larsen K, Tsai CC, Anderson D, Morton WR, Hu SL, Ho RJ. Optimization of Lipid-Indinavir Complexes for Localization in Lymphoid Tissues of HIV-infected Macaques. J Acquir Immune Defic Syndr. 2006 Jun;42(2):155-61. Yimam M, Bui T, and Ho RJY. 2005. Effects of lipid-association on lomustine (CCNU) administered intracerebrally to syngenic 36b-10 astrocytic rat brain tumors. Cancer Lett. 2006 Dec 8;244(2):211-9. Crouthamel MH, Wu D, Yang Z, Ho RJ. A novel MDR1 G1199T variant alters drug resistance and efflux transport activity of P-glycoprotein in recombinant Hek cells. J Pharm Sci. 2006 Dec;95(12):2767-77. Snedecor SJ, Sullivan SM, Ho RJ. Feasibility of weekly HIV drug delivery to enhance drug localization in lymphoid tissues based on pharmacokinetic models of lipid-associated indinavir. Pharm Res. 2006 Aug;23(8):1750-5. Salama NN, Endsley A, Ho RJ. Recent developments in drug targets and delivery of anti-HIV drugs. Infect Disord Drug Targets. 2006 Jun;6(2):107-19. Review. Yow CM, Wong CK, Huang Z, Ho RJ. Study of the efficacy and mechanism of ALA-mediated photodynamic therapy on human hepatocellular carcinoma cell. Liver Int. 2007, Mar;27(2):201-208.
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