UW School of Pharmacy - Department of Pharmaceutics

Recent Publications:

Rosenberg MF, Mao Q, Holzenburg A, Ford RC, Deeley RG, and Cole SPC. The Structure of Multidrug Resistance Protein 1 (MRP1/ABCC1): Crystallization and Single-Particle Analysis Studies. J. Biol. Chem. 2001; 276, 16076-16082.

Leslie EM, Mao Q, Oleschuk CJ, Deeley RG,and Cole SPC. Modulation of Multidrug Resistance Protein 1 (MRP1/ABCC1) Transport and ATPase Activities by Interaction with Dietary Flavonoids. Mol. Pharmacol. 2001; 59, 1171-1180.

Mao Q, Qiu W, Weigl KE, Lander PA, Tabas LB, Shephard RL, Dantzig AH, Deeley RG, and Cole SPC. GSH-Dependent Photolabeling of Multidrug Resistance Protein MRP1(ABCC1) by [125I]-LY475776: Evidence of a Major Binding Site in the COOH-Proximal Membrane Spanning Domain. J. Biol. Chem. 2002; 277, 28690-28690.

Gupta A, Zhang Y, Unadkat JD, and Mao Q. HIV Protease Inhibitors are Inhibitors but not Substrates of the Human Breast Cancer Resistance Protein (BCRP/ABCG2). J. Pharmacol. Exp. Ther. 2004; 310, 334-341.

Mao Q, Conseil G, Gupta A, Cole SPC, and Unadkat JD. Functional Expression of the Human Breast Cancer Resistance Protein (BCRP/ABCG2) in Pichia pastoris. Biochem. Biophys. Res.Commun. 2004; 320, 730-737.

Vethanayagam RR, Wang H, Gupta A, Zhang Y, Lewis F, Unadkat JD, Mao Q. Functional Analysis of the Human Variants of BCRP: I206L, N590Y, and D620N. Drug Metab Dispos. 2005; 33(6):697-705.

Mao Q and Unadkat JD. Role of the Breast Cancer Resistance Protein (BCRP/ABCG2) in Drug Transport. AAPS J. 2005; 7(1):E118-33.

Wu P, Oleschuk CJ, Mao Q, Keller BO, Deeley RG, Cole SP. Analysis of Human Multidrug Resistance Protein 1 (ABCC1) by MALDI-TOF Mass Spectrometry: Towards Identification of Leukotriene C4 Binding Sites. Mol Pharmacol. 2005; 68:1455-1465

Zhang Y, Gupta A, Wang H, Zhou L, Vethanayagam RR, Unadkat JD, and Mao Q. BCRP Transports Dipyridamole and Is Inhibited by Calcium Channel Blockers. Pharm. Res. 2005; 11(12):2023-2034.
Wang H, Zhou L, Gupta A, Vethanayagam RR, Y. Zhang Y, Undakat JD, and Mao Q. Regulation of BCRP/ABCG2 Expression by Progesterone and 17ß-Estradiol in Human Placental BeWo Cells. Am J Physiol Endocrinol Metab. 2006; 290:E798-E807.
Gupta A, Dai Y, Vethanayagam RR, Hebert MF, K.E. Thummel KE, Unadkat JD, Ross DD, and Mao Q. Cyclosporin A, Tacrolimus and Sirolimus Are Potent Inhibitors of the Human Breast Cancer Resistance Protein (ABCG2) and Reverse Resistance to Mitoxantrone and Topotecan. Cancer Chemother Pharmacol. 2006; 58:374-383.

Wang H, Wu X, Hudkins K, Mikheev A, Zhang H, Gupta A, Unadkat JD, and Mao Q. Expression of the Breat Cancer Resistance Protein (Bcrp1/Abcg2) in Tissues from Pregnant Mice: Effects of Pregnancy and Correlations with Nuclear Receptors. Am J Physiol Endocrinol Metab. 2006; 291: E1295-E1304.

Gupta A, Unadkat JD and Mao Q. Interactions of Azole Antifungal Agents with the Human Breast Cancer Resistance Protein (BCRP/ABCG2). J. Pharm. Sci. 2007;96:3226-3235.

Zhang Y, Wang H, Unadkat JD and Mao Q. Bcrpl Limits Fetal Distribution of Nitrofurantoin in the Pregnant Mouse. Drug Metab. Dispos. 2007; 35:2154-2158.

Wang H, Unadkat JD and Mao Q. Hormonal Regulation of BCRP Expression in Human Placental BeWo Cells. Pharm. Res. 2008; 25: 444-452.

Wang H, Lee EW, Zhou L, Leung PC, Ross D, Unadkat JD, Mao Q. Progesterone Receptor (PR) Isoforms, PRA and PRB, Differentially Regulate Expression of the Breast Cancer Resistance Protein (BCRP) in Human Placental Choriocarcinoma BeWo Cells. Mol. Pharmacol. 2008; 73: 845-854.

Zhou L, Naraharisetti SB, Wang H, Unadkat JD, Hebert MF, Mao Q. The Breast Cancer Resistance Protein (Bcrp1/Abcg2) Limits Fetal Distribution of Glyburide in the Pregnant Mouse - An OPRU Network and UW SCOR Study. Mol. Pharmacol. 2008; 73: 949-959.

Mao Q. BCRP/ABCG2 in the placenta: Expression, Function and Regulation. Pharm Res. (2008) in press.

Zhang H, Wu X, Wang H, Mikheev AM, Mao Q, and Unadkat JD. Effect of pregnancy on cytochrome P450 3a and P-glycoprotein expression and activity in the mouse: mechanisms, tissue specificity, and time course. Mol. Pharmacol. 2008; in press.