|
|
Thummel, Kenneth
E. - Professor and Chair
Recent Publications:
- Lin Y, Dowling
A, Quigley S, Farin FM, Zhang J, Lamba J, Schuetz E, and Thummel K.
Post-transcriptional control of polymorphic CYP3A5 expression and contribution
to hepatic and intestinal midazolam metabolism. Mol Pharmacol 2002,
62:162-172.
- Emery, M.G., Fisher,
J.M., Chien, J.Y., Kharasch, E.D., Dellinger, E.P., Kowdley, K.V. and
Thummel, K.E.: Cytochrome P450 2E1 activity before and after weight
loss in morbidly obese subjects with non-alcoholic fatty liver disease.
Hepatology 2003, 38:428-35.
- Hebert, M.F., Dowling,
A.L.S., Gierwatowski C., Lin, Y.S., Edwards, K. L., Davis, C.L., Marsh,
C.L., Schuetz, E.G. and Thummel, K.E.: Association between MDR1 (multidrug
resistance transporter) genotype and post-liver transplantation renal
dysfunction in patients receiving calcineurin inhibitors. Pharmacogenetics
2003, 13:661-74.
- Isoherranen N,
Kunze KL, Allen KE, Nelson WL, Thummel KE. Role of itraconazole metabolites
in CYP3A4 inhibition. Drug Metab Dispos. 2004, Oct;32(10):1121-31.
- McConn DJ 2nd,
Lin YS, Allen K, Kunze KL, Thummel KE. Differences in the inhibition
of cytochromes P450 3A4 and 3A5 by metabolite-inhibitor complex-forming
drugs. Drug Metab Dispos. 2004, Oct;32(10):1083-91.
- Huang W, Lin YS,
McConn DJ 2nd, Calamia JC, Totah RA, Isoherranen N, Glodowski M, Thummel
KE. Evidence of significant contribution from CYP3A5 to hepatic drug
metabolism. Drug Metab Dispos. 2004, Dec;32(12):1434-45.
- Dai Y, Iwanaga
K, Lin YS, Hebert MF, Davis CL, Huang W, Kharasch ED, Thummel KE. In
vitro metabolism of cyclosporine A by human kidney CYP3A5. Biochem Pharmacol.
2004, Nov 1;68(9):1889-902.
- Rieder MJ, Reiner
AP, Gage BF, Nickerson DA, Eby CS, McLeod HL, Blough DK, Thummel KE,
Veenstra DL, Rettie AE. Effect of VKORC1 haplotypes on transcriptional
regulation and warfarin dose. N Engl J Med. 2005, Jun 2;352(22):2285-93.
- Kharasch ED, Thummel
KE, Watkins PB. CYP3A Probes Can Quantitatively Predict the In Vivo
Kinetics of Other CYP3A Substrates and Can Accurately Assess CYP3A Induction
and Inhibition. Mol Interv. 2005, Jun;5(3):151-3.
- Dai Y, Hebert
MF, Isoherranen N, Davis CL, Marsh C, Shen DD, Thummel KE. Effect of
CYP3A5 Polymorphism on Tacrolimus Metabolic Clearance In Vitro. Drug
Metab Dispos. 2006, 34:836-47.
- Zhou C., Assem,
M., Tay, J., Watkins, P.B., Blumberg B., Schuetz, E.D. and Thummel,
K.E: Steroid and xenobiotic receptor and vitamin D receptor crosstalk
mediates CYP24 express and drug-induced osteomalacia. J Clin Invest.
2006, 116:1703-12.
- Xu, Y., Iwanaga, K., Zhou, C., Cheesman M., Farin, F., and Thummel, K.E.: Selective induction of intestinal CYP3A23 by 1?,25-dihydroxyvitamin D3 in rats. Biochem Pharmacol. 2006, 72:385-92.
- Zhou, C., Tabb, M.M., Nelson, E.L., Sadatrafiei, A., Lin, M., Mallick, S., Forman, B.M., Thummel, K.E., and Blumberg B.: Mutual repression between SXR and NF-KB signaling pathways link xenobiotic metabolism and inflammation. J Clin Invest. 2006, 116:2280-9.
- Zhou C, Poulton EJ, Grun F, Bammler TK, Blumberg B, Thummel KE, Eaton DL. The dietary isothiocyanate sulforaphane is an antagonist of the human steroid and xenobiotic nuclear receptor. Mol Pharmacol. 2007, Jan;71(1):220-9.
- Huang, W., Kalhorn, T.F., Baillie, M., Shen, D.D. and Thummel K.E.: Determination of free and total cortisol on plasma and urine by liquid chromatography-tandem mass spectrometry. Ther Drug Monit. 2007, Apr;29(2):215-24 .
- Thummel KE. Gut instincts: CYP3A4 and intestinal drug metabolism. J Clin Invest. 2007, Nov;117(11):3173-6.
- Templeton, I.,Thummel, K.E., Kharasch, E.D., Kunze, K.L., Hoffer, C. Nelson, W.L., and Isoherranen, N.: Contribution of Itraconazole Metabolites to Inhibition of CYP3A4 in vivo. Clin Pharmacol Ther. 2008, Jan;83(1):77-85 .
- Isoherranen N, Ludington SR, Givens RC, Lamba JK, Pusek SN, Dees EC, Blough DK, Iwanaga K, Hawke RL, Schuetz EG, Watkins PB, Thummel KE, Paine MF. The influence of CYP3A5 expression on the extent of hepatic CYP3A inhibition is substrate-dependent: an in vitro-in vivo evaluation. Drug Metab Dispos. 2008, Jan;36(1):146-54.
- Hashizume T, Xu Y, Mohutsky MA, Alberts J, Hadden C, Kalhorn TF, Isoherranen N, Shuhart MC, Thummel KE. Identification of human UDP-glucuronosyltransferases catalyzing hepatic 1?,25-dihydroxyvitamin D(3) conjugation. Biochem Pharmacol. 2008, Mar 1;75(5):1240-50 .
|
