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Unadkat, Jashvant D. - Professor

Recent Publications:

  • Lai Y, Bakken AD, and Unadkat JD. Simultaneous expression of hCNT1-CFP and hENT1-YEP in Mardin-Darby canine kidney (MDCK) cells: Localization and vectorial transport studies. J Biol Chem. 2002 Oct 4; 277(40): 37711-7.

  • Lai Y, Tse CM, and Unadkat JD. Mitochondrial expression of the human equilibrative nucleoside transporter 1 (hENT1) results in enhanced mitochondrial toxicity of antiviral drugs. J Biol Chem. 2004; 279(6) :4490-4497.

  • Winter HR, Trapnell CB, Slattery JT, Jacobson M, Greenspan DL, Hooton TM, Unadkat JD. The effect of clarithromycin, fluconazole, and rifabutin on dapsone hydroxylamine formation in individuals with human immunodeficiency virus infection (AACTG 283). Clin Pharmacol Ther. 2004 Dec; 76(6):579-87.

  • Lai Y, Lee EW, Ton CC, Vijay S, Zhang H, Unadkat JD. Conserved residues F316 and G476 in the concentrative nucleoside transporter 1 (hCNT1) affect guanosine sensitivity and membrane expression, respectively. Am J Physiol Cell Physiol. 2005 Jan; 288(1):C39-45.

  • Sasongko L, Link JM, Muzi M, Mankoff DA, Yang X, Collier AC, Shoner SC, Unadkat JD. Imaging P-glycoprotein transport activity at the human blood-brain barrier with positron emission tomography. Clin Pharmacol Ther. 2005 Jun;77(6):503-14.

  • Mathias AA, Hitti J, Unadkat JD. P-glycoprotein and Breast Cancer Resistance Protein expression in human placentae of various gestational ages. Am J Physiol Regul Integr Comp Physiol. 2005. Oct; 289(4):R963-9.

  • Mathias AA, Maggio-Price L, Lai Y, Gupta A, Unadkat JD. Changes in Pharmacokinetics of Anti-HIV Protease Inhibitors during Pregnancy: The Role of CYP3A and P-Glycoprotein. J Pharmacol Exp Ther. 2006 Mar; 316(3):1202-9.

  • Endres CJ, Hsiao P, Chung FS, Unadkat JD. The role of transporters in drug interactions.
    Eur J Pharm Sci. 2006 Apr; 27(5):501-17.

  • Hsiao P, Sasongko L, Link JM, Mankoff DA, Muzi M, Collier AC, Unadkat JD. Verapamil P-glycoprotein transport across the rat blood-brain barrier: cyclosporine A concentration-inhibition analysis and comparison with human data. J Pharmacol Exp Ther. 2006 May;317(2):704-10.

  • Unadkat JD, Wara DW, Hughes MD, Mathias AA, Holland DT, Paul ME, Connor J, Huang S, Nguyen BY, Watts DH, Mofenson LM, Smith E, Deutsch P, Kaiser KA, Tuomala RE. Pharmacokinetics and safety of Indinavir in immunodeficiency virus-infected pregnant women. Antimicrob Agents Chemother. 2007 Feb;51(2):783-6.

  • Kirby B, Kharasch ED, Thummel KT, Narang VS, Hoffer CJ, Unadkat JD. Simultaneous measurement of in vivo P-glycoprotein and cytochrome P450 3A activities. J Clin Pharmacol. 2006 Nov; 46(11):1313-9.

  • Lee EW, Lai Y, Zhang H, Unadkat JD. Identification of the mitochondrial targeting signal of the human equilibrative nucleoside transporter 1 (hENT1): implications for interspecies differences in mitochondrial toxicity of fialuridine. J Biol Chem. 2006 Jun 16; 281(24):16700-6.

  • Hu H, Endres CJ, Chang C, Umaapathy NS, Lee EW, Fei YJ, Itagaki S, Swann PW, Ganapathy V, Unadkat JD. Electrophysiological characterizatin and modeling of the structure activity relationship of the human concentrative nucleoside transporter 3 (hCNT3). Mol Pharmacol. 2006 May;69(5):1542-53.

  • Kirby BJ, Unadkat JD. Grapefruit juice, a glass full of drug interactions? Clin Pharmacol Ther. 2007 May;81(5):631-3.

  • Dixit V, Hariparsad N, Desai P, Unadkat JD. In vitro LC-MS cocktail assays to simultaneously determine human cytochrome P450 activities. Biopharm Drug Dispos. 2007 Jul;28(5):257-62.

  • Gupta A, Unadkat JD, Mao Q. Interactions of azole antifungal agents with the human breast cancer resistance protein (BCRP). J Pharm Sci. 2007 Dec;96(12):3226-35.

  • Kaddoumi A, Choi SU, Kinman L, Whittington D, Tsai CC, Ho RJ, Anderson BD, Unadkat JD. Inhibition of P-glycoprotein activity at the primate blood-brain barrier inceases the distribution of nelfinavir into the brain but not into the cerebrospinal fluid. Drug Metab Dispos. 2007 Sep;35(9):1459-62.

  • Dixit V, Hariparsad N, Li F, Desai P, Thummel KE, Unadkat JD. Cytochrome P450 enzymes and transporters induced by anti-human immunodeficiency virus protease inhibitors in human hepatocytes: implications for predicting clinical drug interactions. Drug Metab Dispos. 2007 Oct;35(10):1853-9. Epub 2007 Jul 16.

  • Govindarajan R, Bakken AH, Hudkins KL, Lai Y, Casado FJ, Pastor-Anglada M, Tse CM, Hayashi J, Unadkat JD. In situ hybridization and immunolocalization of concentrative and equilibrative nucleoside transporters in the human intestine, liver, kidneys, and placenta. Am J Physiol Regul Integr Comp Physiol. 2007 Nov;293(5):R1809-22.

  • Zhang Y, Wang H, Unadkat JD, Mao Q. Breast cancer resistance protein 1 limits fetal distribution of nitrofurantoin in the pregnant mouse. Drug Metab Dispos. 2007 Dec;35(12):2154-8.

  • Wang H, Unadkat JD, Mao Q. Hormonal Regulation of BCRP Expression in Human Placental BeWo Cells. Pharm Res. 2008 Feb;25(2):444-52.

  • Naraharisetti SB, Kirby BJ, Hebert MF, Easterling TR, Unadkat JD. Validation of a sensitive LC-MS assay for quantification of glyburide and its metabolite 4-transhydroxy glyburide in plasma and urine: an OPRU Network study. J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Dec 1;860(1):34-41.

  • Wang H, Lee EW, Zhou L, Leung PC, Ross DD, Unadkat JD, Mao Q. Progesterone receptor (PR) isoforms PRA and PRB differentially regulate expression of the breast cancer resistance protein in human placental choriocarcinoma BeWo cells. Mol Pharmacol. 2008 Mar;73(3):845-54.

  • Hsiao P, Bui T, Ho RJ, Unadkat JD. n vitro-to-in vivo prediction of P-glycoprotein-based drug interactions at the human and rodent blood-brain barrier. Drug Metab Dispos. 2008 Mar;36(3):481-4.

  • Zhou L, Naraharisetti SB, Wang H, Unadkat JD, Hebert MF, Mao Q. The breast cancer resistance protein (Bcrp1/Abcg2) limits fetal distribution of glyburide in the pregnant mouse: an obstetric-fetal pharmacology research unit network and university of washington specialized center of research study. Mol Pharmacol. 2008 Mar;73(3):949-59.

  • Hebert M, Easterling T, Kirby B, Carr D, Buchanan M, Rutherford T, Thummel K, Fishbein D, Unadkat J. Effects of Pregnancy on CYP3A and P-glycoprotein Activities as Measured by Disposition of Midazolam and Digoxin: A University of Washington Specialized Center of Research Study. Clin Pharmacol Ther. 2008 Feb 20. In press.

  • Kirby BJ, Kalhorn T, Hebert M, Easterling T, Unadkat JD. Sensitive and specific LC-MS assay for quantification of digoxin in human plasma and urine. Biomed Chromatogr. 2008 Mar 3. In press.


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