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PCEUT 501 Advanced Pharmacokinetics 1
(5)
Shen, Slattery, Thummel, Unadkat, Ho. Drug absorption, distribution,
excretion, metabolism, and effects in mammalian systems. Compartmental
model and model-independent approaches examined. Drug disposition is studied
in a physiologically realistic context taking nonlinear events into account.
Aimed at development of innovative methods for data analysis and evaluation
in biological systems. Prerequisite: 406. Offered: Sp.
PCEUT 502 Advanced Pharmacokinetics
Concepts (5)
Levy, Shen, Slattery. Recent developments and emerging concepts
in theoretical and experimental pharmacokinetics. Critical analysis of
the current literature. Prerequisite: 406. Offered: Sp.
PCEUT 506 Pharmaceutical Principles
(4)
Shen. Coverage of basic pharmacokinetic concepts in an interactive
format. Students are given reading assignments prior to class as a point
of entry into the material. Topics emphasize the physiologic basic for
mathematical models of drug distribution, clearance, and pharmacologic
effect. Offered: W.
PCEUT 507 Topics in Clinical Pharmacokinetics
(1, max. 12)
Gibaldi. New and important findings and trends in pharmacokinetics,
biopharmaceutics, drug metabolism, and drug toxicity, with particular
emphasis on clinical significance and applicability. Credit/no credit
only. Prerequisite: PCEUT 405 or equivalent. Offered: AWSp.
PCEUT 510 Pharmacokinetics of Drug
Interactions (3)
Shen. Common pharmacokineticmechanisms underlying the clinically
important interactions between drugs. Interactions involving gastrointestinal
absorption, serum drug protein binding, excretory and metabolic clearance
processes. Prerequisite: 406 or equivalent. Offered: Sp.
PCEUT 520 Seminar (1, max. 5)
Graduate students attend seminars and make one formal presentation per
year while in residence: 1 credit per year is allowed. Credit/no credit
only. Offered: AWSp.
PCEUT 525 Laboratory Methods in
Drug Metabolism (3)
Atkins, Daggett, Kunze, Rettie, Thummel. Examines laboratory techniques
for the isolation and characterization of subcellular fractions from human
tissues. Includes the determination of product formation kinetics, in
in vitro-in vivo kinetic scaling, quantitation of specific enzyme contents
in human tissue, and computer-assisted prediction of metabolites of catalytically
sensitive drugs. Offered: jointly with MEDCH 525; Sp.
PCEUT 534 Pharmaceutical Analysis
(3)
Slattery. Methods of drug and metabolite analysis from biologic
matrices. Emphasis on practical aspects of assay design, optimization,
and validation. Approaches to troubleshooting both assay methodology and
instrumentation problems are also covered. Credit/no credit only. Offered:
W.
PCEUT 583 Topics in Pharmaceutics
(1, max. 15)
Ho. Discussion of pertinent articles from current literature and
recent laboratory results. Credit/no credit only. Offered: AWSp.
PCEUT 586 Pharmaceutical Biotechnology
(3)
Ho, Thummel, Gibaldi. Applications of biotechnology in designing
therapeutic products, with emphasis on research and development of biopharmaceuticals.
Molecular cloning, production, physical stability, delivery systems of
protein therapeutics in relation to pharmacokinetic and therapeutic responses.
Prerequisite: concurrent registration in 405 and PHCOL 401 or permission
of instructor; BIOC 405/406. Offered: W. Course Materials (password required)
PCEUT 600 Independent Study or
Research (*)
Credit/no credit only. Offered AWSpS.
PCEUT 700 Master's Thesis (*)
Credit/no credit only. Offered AWSpS.
PCEUT 800 Doctoral Dissertation
(*)
Credit/no credit only. Offered AWSpS. |
