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Undergraduate Courses: PCEUT 331
PHARMACEUTICS 331 Part I. (1 point each) Mark A for TRUE and B for FALSE on your
mark-sense form. Note: MW's and formulae are listed on the last page. 1. A given set of measurements can be precise, but inaccurate. TRUE 2. At a given temperature and pressure only one crystal form of a drug
will be stable. TRUE 3. Isothermic dissolution is a characteristic of a real solution. FALSE 4. Lactic acid (Ka = 1.38x10-4) is a weaker acid than acetic acid (pKa
= 4.76). FALSE 5. Increasing solvent temperature will always increase drug solubility.
FALSE 6. Amorphous preparation of insulin contains alpha and beta crystalline
forms.FALSE 7. Amino acids are amphoteric electrolytes. TRUE 8. Osmolarity of 0.5% NaCl is identical to 0.5% H3BO3. FALSE 9. The 20 milli-equivalent sodium per liter listed in the urine chemistry
report is the same as 20x10-3 M sodium. TRUE 10. Desmopressin, a polypeptide drug will be most soluble in a solution
with pH value equal to its pI. FALSE 11. Addition of succinate group to prenisolone will reduce its solubility
because succinate group will increase prenisolone's hydrophobicity.
FALSE 12. When the pH of a solution is much greater than pKa of an acid, practically
all the drug molecules will be in ionic form. TRUE 13. Lyophylization is a process of drying in which water is sublimed
from the product after it is frozen. TRUE 14. For aqueous eye drops solutions, a sodium chloride equivalent range of .7-1.4% and pH range of 5.5-7.5 must be met for isotonicity. TRUE PART II. MULTIPLE CHOICE QUESTIONS (2 points each) Answer the following multiple choice questions by marking the mark-sense
form with the correct choice. No points will be awarded to answers that
are marked with more than one letter. The nasal decongestant, Nostril (phenylephrine-HCl) 0.25% contains several inactive ingredients. Match functions listed in A-E with the ingredients listed in questions 15-16.
15. Benzalkonium chloride ________B___________ 16. Boric acid and sodium borate ________D_________ 17. To prepare a 7.5 µmole Morphine sulfate for epidural
injection, you need to draw the following volume from a stock vial containing
15mg/ml or Morphine sulfate
D. 33.4 ml 18. The therapeutic blood concentration of Digoxin is 0.5-2.0
ng/ml. Blood Digoxin concentration of 4 ng/ml or higher results in drug
toxicity. Which of these statement(s) is (are) correct?
19. In a dispersed system the order of particle size is
20. Antiviral didanosine is inactivated in the acidic environment
(pH 1-2) of stomach. You are asked to prepare 100 ml of didanosine oral
solutions at pH 7.0 in sodium bicarbonate/carbonic acid buffer system
(pKa = 6.1) to reduce drug degradation in stomach. How many moles
of sodium bicarbonate must be added to 20mM carbonic acid to prepare 100
ml buffer at pH=7?
21. Pentobarbital is an acidic drug with pKa=8.1. At the physiologic
condition of pH=7.4, the percentage of drug in the unionized form
will be
22. Surfactants are used in pharmaceutical formulations to
23. Which of the following water is not required to be free of pyrogen?
24. What is the osmolarity of an IV solution containing 12.5%
Mannitol and 0.9% NaCl?
25. Acyclovir is used to treat herpes virus infections in children at
80mg/kg/day. For a 15 kg child, you have prepared an oral suspension of
80mg/ml. How many teaspoons (tsp) would you ask the patient to take per
day?
26. How many grams of NaCl will be needed to make 200 ml of a
Sulfonaimide combination solution containing 2% Sulfadiazine sodium (E
value = 0.24) and 1% Sulfapyridine sodium (E value = 0.23) to be isotonic.
27. You are consulted to compare a new peptide drug, Peptidsone with Prednisolone sodium phosphate injection . Prednisolone sodium phosphate is given at 20 mg injection dose. Assuming the distribution and metabolism profiles of both drugs to be similar, to provide a dose equivalent to Prednisolone sodium phosphate, you will choose the following dose for Peptidsone
Rx Hyoscyamine sulfate 0.005 Lactose q.s. 0.200 Dispense such capsules XII 28. On the balance you have in your pharmacy, a 5mg weight moves the
rest point one division. What is the minimum weighable quantity for your
balance (with 5% error)?
29. Using this balance and assuming you want to make 13 capsules with
little wastage of lactose, you will weigh out the following amount of
hyoscyamine sulfate and lactose:
A. 65 mg 30. The amount of lactose you will utilize in TOTAL (including
that used above) in formulating this prescription will be:
31. If wastage of lactose is not an issue, you will use the following
amount of lactose:
32. The amount of lactose in each of the dispensed capsules will
be:
FORMULAS 1 mole = 6.023 x1023 molecules
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