Short Name | PDE Isozyme Gene Families | Number of genes | Number of reported Splice variants | Evidence for additional splice variants. |
PDE1 | CaM-dependent PDEs | 3 | 9+ | yes |
PDE2 | cGMP-stimulated PDEs | 1 | 2 | yes |
PDE3 | cGMP-inhibited PDEs | 2 | 2+ | yes |
PDE4 | cAMP-specific PDES | 4 | 15+ | yes |
PDE5 | cGMP-specific PDEs | 2 | 2 | possible |
PDE6 | Photoreceptor PDEs | 3 | 2 | possible |
PDE7 | HCP1-PDE * | 1 | 1 | possible |
FIGURE 1: Explanation/Guidelines for Nomenclature in Table 2
Green----Species (first 2 letters)
Purple---PDE Gene Family (3 Capital Letters + 1 or 2 Arabic numerals)
Red------PDE Gene within family (Capital Letter)
Yellow---Splice variant (Arabic Numeral)
Blue-----Report ( Capital Letter)
example: HSPDE13A2A
The first two letters represent the species, for example HS for Homo sapiens. The next three letters plus one or two Arabic numerals designate the cyclic nucleotide phosphodiesterase gene family. The next letter represents the individual gene product within the family. The final Arabic numeral represents the splice variant and the final letter allows GenBank to assign a unique locus field designation based on when the entry was submitted and also to give different locus names to conflicting or incomplete sequences. It is hoped that most investigators will change their current GenBank LOCUS entries to this system and also will in the future use this nomenclature in the titles and abstracts of their manuscripts and in their GenBank submissions so that a commonly recognized order for nomenclature may be instituted. This system should allow for future expansion ( at least until the number of gene families or splice variants exceeds 99 or the number of genes within any one gene family exceeds 26). It was also the consensus of discussion that more descriptive names based on regulation and function continue to serve a useful role in the text of most manuscripts. For example, a paper on a PDE6 family member would be likely to include the terms "light activated or ROS or photoreceptor PDE" ; similarly one discussing the PDE2 family would be likely to include the terms "cGMP-stimulated PDE or cGS-PDE". Note, according to current Genbank rules, the GenBank LOCUS name must end in a letter, not a number.
A similar nomenclature system has been approved by the Human Genome Project Nomenclature Committee with the following differences. First, they omit the species since all are human sequences. Second, they use an asterisk followed by a second Arabic numeral to represent alleles rather than splice variants. The theoretical example shown above for a GenBank entry would be as follows in the Human Genome Entry. It is expected that the current names in the Human Genome data bank will be changed to reflect this new nomenclature.
Purple-----------PDE Gene family (3 Capital letters)
Purple + Red---Specific PDE Gene (PDE + Arabic numerals + letter)
Blue--------------Allele
Included in this table are most of the human, bovine and rodent cDNA references listed in GenBank or in recent literature references. Only those thought to be full length products or known to be catalytically active are listed. - GB = GenBank; - HuGP = Human Genome Project; - Acc Number = GenBank Accession Number;
HuGP Name | New GB LOCUS | Old GB LOCUS | ACC Number | Alternate Name | Pub Date | Commentary* |
---|---|---|---|---|---|---|
--- | PDE1 GENE FAMILY | --- | --- | --- | --- | --- |
--- | BTPDE1A1A | BOVBTPDE1A | L34069> | 59k CaM-PDE | 8/91 | comment |
--- | BTPDE1A2A | BOVCNPA | M90358 | 61k CaM-PDE | 8/91 | --- |
--- | BTPDE1B1A | BOVCALPHOS | M94867 | 63k CaM-PDE | 9/92 | --- |
--- | RNPDE1B1A | RATCAMPDE | M94537 | 63k CaM-PDE | 9/92 | --- |
--- | MMPDE1B1A | MUSPDE1B1 | L01695 | 63k CaM-PDE | 12/92 | --- |
PDE1B | HSU56976 | HSPDE1B1A | U56976 | 63k CaM-PDE | 10/96 | --- |
PDE1C | HSPDE1C1A | HSPDE1C1A | U40371 | Hcam3b | 1/96 | comment |
--- | MMPDE1C1A | MMPDE1C1A | L76944 | --- | 10/96 | --- |
--- | RNPDE1C2A | RNPDE1C2A | L41045 | olf CaM-PDE | 6/95 | comment |
PDE1C | HSPDE1C3A | HSPDE1C3A | U43072 | Hcam3a | 1/96 | |
--- | MMPDE1C4A | MMPDE1C4A | L76947 | --- | 10/96 | --- |
--- | MMPDE1C5A | MMPDE1C5A | L76946 | --- | 10/96 | --- |
--- | PDE2 GENE FAMILY | --- | --- | --- | --- | comment |
HuGP Name | New GB LOCUS | Old GB LOCUS | ACC Number | Alternate Name | Pub Date | Commentary |
--- | BTPDE2A1A | BOVCGMPCN | M73512 | cGS-PDE | 10/91 | |
--- | RNPDE2A2A | RNU21101 | U21101 | cGS-PDE | 3/95 | |
--- | BTPDE2A3A | BOVBTPDE2A | L49503 | cGS-PDE | 2/96 | |
PDE2A | HSPDE2A3A | HSU67733 | U67733 | cGS-PDE | 5/97 | --- |
--- | PDE3 GENE FAMILY | --- | --- | --- | --- | comment |
HuGP Name | New GB LOCUS | Old GB LOCUS | ACC Number | Alternate Name | Pub Date | Commentary |
PDE3A | HSPDE3A1A | HUMGMPIPDI | M91667 | cGI-PDE | 5/92 | --- |
--- | RNPDE3B1A | RNCAMPPHA | Z22867 | cGI-PDE | 10/93 | --- |
--- | PDE4 GENE FAMILY | --- | --- | --- | --- | --- |
HuGP Name | New GB LOCUS | Old GB LOCUS | ACC Number | Alternate Name | Pub Date | Commentary |
--- | RNPDE4A1A | RATDUNCEA | M26715,J04554 | RD1 | 3/90 | --- |
--- | RNPDE4A1B | RATPHOSF | L27062 | RPDE8 | 12/93 | --- |
--- | RNPDE4A2A | RATDUNCEC | M26717,J04554 | RD2 | 3/90 | comment |
--- | RNPDE4A3A | RATDUNCEB | M26716,J04554 | RD3 | 3/90 | comment |
--- | RNPDE4A?? | RATPHOCNA | M25348,M28411 | ratPDE2 | 12/89 | --- |
PDE4A | HSPDE4A1 | hRD1 | U97584 | hRD1 | 01/98 | --- |
PDE4A | HSPDE4A4A | HUMPDEAA | M37744 | h-PDE1 | 1/91 | comment |
PDE4A | HSPDE4A4B | HUMPDEA | L20965 | PDE46 * | 12/93 | comment |
PDE4A | HSPDE4A4C | HSU18087 | U18087 | hPDE4Ah6.1 | 2/95 | comment |
PDE4A | HSPDE4A5? | HUMPDEC | L20967 | DPDE2,TM3 | 7/93 | --- |
--- | RNPDE4A5A | RATPHOSA | L27057 | RPDE6 | 12/93 | comment |
--- | RNPDE4A6 | RAT35CA | L36467 | RAT35CA | 3/95 | comment |
PDE4A | HSPDE4A8A | HSU18088 | U18088 | HSPDE4A7 | 8/95 | comment |
PDE4B | HSPDE4B1A | HUMPDEB | L20966 | TM72,DPDE4 | 7/93 | --- |
--- | RNPDE4B1A | RATDPD | J04563 | DPD | 12/89 | --- |
PDE4B | HSPDE4B2A | HSPDE2A | M97515 | --- | 6/93 | --- |
PDE4B | HSPDE4B2B | HUMPDEG | L20971 | PDE32 | 7/93 | --- |
PDE4B | HSPDE4B2C | HUMCAMPB | L12686 | --- | 10/93 | --- |
--- | RNPDE4B2A | RATPHOCAMB | M25350,M28413 | ratPDE4 | 9/89 | --- |
--- | RNPDE4B2B | RATPHOSB | L27058 | RPDE18 | 12/93 | --- |
PDE4B | HSPDE4B3A | --- | U85048 | --- | 01/98 | --- |
--- | RNPDE4B3A | --- | U95748 | RPDE74 | 01/98 | --- |
PDE4B | HSPDE4B? | ---- | L12685 | HPB102 | 10/93 | comment |
PDE4C | HSPDE4C1A | HUMPDED | L20968 | DPDE1,PDE21 | 7/93 | --- |
PDE4C | HSPDE4C1B | --- | Z46632 | --- | 08/94 | |
--- | RNPDE4C1A | RATPHOCN | M25347,M28410 | ratPDE1 | 9/89 | --- |
--- | RNPDE4C1B | RATPHOSE | L27061 | RPDE36 | 12/93 | --- |
PDE4C | HSPDE4C2A | --- | U88712 | --- | 12/97 | --- |
PDE4C | HSPDE4C3A | --- | U88713 | --- | 12/97 | --- |
PDE4C | HSPDE4C4A | --- | U66346 | 4C791 | 12/97 | --- |
PDE4C | HSPDE4C5A | --- | U66347 | 4C426 | 12/97 | --- |
PDE4C | HSPDE4C6A | --- | U66348 | 4Cdelta54 | 12/97 | comment |
PDE4C | HSPDE4C7A | --- | U66349 | 4Cdelta109 | 12/97 | comment |
PDE4D | HSPDE4D1A | --- | U50157 | --- | 03/96 | --- |
PDE4D | HSPDE4D1B | --- | U79571 | DUN411 | 12/97 | --- |
--- | RNPDE4D1A | RATPHOCAMA | U09455, M25349, M28412 | ratPDE3.1 | 07/89 | --- |
--- | RNPDE4D1B | RATPHOSD | L27060 | RPDE13 | 12/93 | --- |
PDE4D | HSPDE4D2A | --- | U50158 | --- | 03/96 | --- |
PDE4D | HSPDE4D2B | --- | AF012074 | PDE82 | 12/97 | --- |
--- | RNPDE4D2A | RATPDE32 | U09456, M25349 | ratPDE3.2 | 7/89 | --- |
PDE4D | HSPDE4D3A | HUMPDEF | L20970 | DPDE3,PDE43 | 12/93 | --- |
PDE4D | HSPDE4D3B | --- | U50159 | --- | 03/96 | --- |
--- | RNPDE4D3A | RATPHOSC | L27059 | RPDE3 | 12/93 | --- |
--- | RNPDE4D3B | RATPDE33 | U09457 | ratPDE3.3 | 7/94 | --- |
PDE4D | HSPDE4D4A | HUMPDEE | L20969 | DPDE3,PDE39 | 12/93 | --- |
--- | RNPDE4D4A | --- | AF031373 | --- | 12/97 | --- |
PDE4D | HSPDE4D5A | --- | AF012073 | PDE79 | 12/97 | --- |
PDE4D | HSPDE4D?? | --- | U02882 | h-PDEIVD | 12/93 | --- |
--- | PDE5 GENE FAMILY | --- | --- | --- | --- | --- |
HuGP Name | New GB LOCUS | Old GB LOCUS | ACC Number | Alternate Name | Pub Date | Commentary |
--- | BTPDE5A1 | BOVPCGB8X | L16545 | cGB-PDE ## | 10/93 | --- |
--- | RNPDE5A2 | D89093 | D89093 | --- | 12/97 | --- |
--- | PDE6 GENE FAMILY | --- | --- | --- | --- | comment |
HuGP Name |
New GB LOCUS
|
Old GB LOCUS | ACC Number | Alternate Name | Pub Date | Commentary |
PDE6A | HSPDE6A1A | HUMCGPRA | M26061 | ROS-PDEa | 6/90 | --- |
--- | BTPDE6A1A | BOVCGMP01 | M27541 | ROS-PDEa | 10/87 | --- |
--- | BTPDE6A1B | BOVCGPDAG | M26043 | ROS-PDEa | 6/90 | --- |
--- | MMPDE6A1A | MMPA | X60664 | ROS-PDEa | 8/91 | --- |
PDE6B | HSPDE6B1A | HSCGMPPM | X66142 | ROS-PDEb | 8/93 | --- |
--- | BTPDE6B1A | BOVCGMP | J05553 | ROS-PDEb | 6/90 | --- |
--- | MMPDE6B1A | MUSPDE | X55968 | ROS-PDEb | 6/91 | --- |
--- | MMPDE6B1B | MMPB | X60133 | ROS-PDEb | 8/91 | --- |
--- | BTPDE6C1A | BOVPDE | M37838 | Cone alpha' | 6/90 | --- |
--- | BTPDE6C1B | BOVPDEAP | M33140 | Cone alpha' ^^ | 6/90 | --- |
--- | BTPDE6D1A | BTPDE6D1A | U65073 | Rod delta | 10/96 | --- |
PDE6G | HSPDE6G1A | HUMPDEGA | M36476 | Rod gamma | 9/90 | --- |
--- | BTPDE6G1A | BTCGMPPR | X04270 | Rod gamma | 6/87 | --- |
--- | MMPDE6G1A | MUSCGMPPD | Y00746 | Rod gamma | 5/88 | --- |
--- | BTPDE6H1A | BOVPDEG | J05578 | Cone gamma | 5/91 | --- |
--- | PDE7 GENE FAMILY | --- | --- | --- | --- | --- |
HuGP Name | New GB LOCUS | Old GB LOCUS | ACC Number | Alternate Name | Pub Date | Commentary |
PDE7A | HSPDE7A1A | HUMCAMPHOS | L12052 | HCP1 | 8/93 | --- |
--- | HSPDE7A2A | --- | U68171 | --- | 11/96 | --- |
--- | PDE8 GENE FAMILY | --- | --- | --- | --- | --- |
HuGP Name | New GB LOCUS | Old GB LOCUS | ACC Number | Alternate Name | Pub Date | Commentary |
--- | MMPDE8A | --- | AF067806 | --- | 7/98 | --- |
--- | HSPDE8A | --- | AF056490 | --- | 6/98 | "truncated" |
--- | HSPDE8B | --- | AF079529 | --- | 11/98 | "truncated" |
--- | PDE9 GENE FAMILY | --- | --- | --- | --- | --- |
HuGP Name | New GB LOCUS | Old GB LOCUS | ACC Number | Alternate Name | Pub Date | Commentary |
--- | MMPDE9A1 | --- | AF031147 | --- | 6/98 | --- |
--- | MMPDE9A2(?) | --- | AF068247 | --- | 6/98 | --- |
--- | HSPDE9A2 | --- | AF048837 | --- | 6/98 | --- |
--- | HSPDE9A1(?) | --- | AF067223 | --- | 7/98 | --- |
--- | HSPDE9A2(?) | --- | AF067224 | --- | 7/98 | --- |
--- | HSPDE9A3(?) | --- | AF067225 | --- | 7/98 | --- |
--- | HSPDE9A4(?) | --- | AF067226 | --- | 7/98 | --- |
--- | PDE10 GENE FAMILY | --- | --- | --- | --- | --- |
HuGP Name | New GB LOCUS | Old GB LOCUS | ACC Number | Alternate Name | Pub Date | Commentary |
--- | MMPDE10A | --- | AF110507 | --- | 5/99 | --- |
--- | HSPDE10A | --- | AB020593 | --- | 6/99 | --- |
--- | HSPDE10A1 | --- | AF127479 | --- | 5/99 | --- |
--- | HSPDE10A2 | --- | AF127480 | --- | 5/99 | "truncated" |
Updates to this table can be made via the PDE update form. All updates are reviewed before publication on this website.
*Comments may be added via the PDE comment form. All comments are reviewed before publication on this website but it is expected that all will be displayed.