Projects
- Phasic dopamine transmission in economic decision making
- Phasic dopamine transmission in reward learning
- Event-related dopamine release during drug taking
- Effects of drugs of abuse on dopamine release
- Phasic dopamine transmission in the human brain during behavior
Techniques
- Fast-scan cyclic voltammetry
- Intracranial microstimulation
- Intracranial microinjection
- Viral-mediated gene transfer (in collaboration with John Neumaier)
- Drug self-administration
- Food self-administration
- Decision-making operant behavior
- Computational modeling (in collaboration with Read Montague)
Publications
- The protective action encoding of serotonin transients in the human brain
Moran RJ, Kishida KT, Lohrenz T, Saez I, Laxton AW, Witcher MR, Tatter SB, Ellis TL, Phillips PEM, Dayan P and Montague PR
Neuropsychopharmacology (in press)- Peroxiredoxin 6 mediates Gαi protein-coupled receptor inactivation by cJun kinase
Nature Communications 8 743 (2017)
Schattauer SS, Land BB, Reichard KL, Abraham AD, Burgeno LM, Kuhar JR, Phillips PEM, Ong SE and Chavkin C
- Peroxiredoxin 6 mediates Gαi protein-coupled receptor inactivation by cJun kinase
- Dopamine encodes retrospective temporal information in a context-independent manner
Fonzi KM, Lefner MJ, Phillips PEM and Wanat MJ
Cell Reports 20, 1765-1774 (2017) - Pramipexole enhances disadvantageous decision-making: Lack of relation to changes in phasic dopamine release
Pes R, Godar SC, Fox AT, Burgeno LM, Strathman HJ, Jarmolowicz DP, Devoto P, Levant B, Phillips PEM, Fowler SC and Bortolato M
Neuropharmacology 114, 77-87 (2017) - Hitchhiker's guide to voltammetry: acute and chronic electrodes for in vivo fast-scan cyclic voltammetry
Rodeberg NT, Sandberg SG, Johnson JA, Phillips PEM and Wightman RM
ACS Chemical Neuroscience 8, 221-234 (2017) - Genetic isolation of hypothalamic neurons that regulate context-specific male social behavior
Soden ME, Miller SM, Burgeno LM, Phillips PEM, Hnasko TS and Zweifel LS
Cell Reports 16, 304-313 (2016) - Making risk-takers settle
Hollon NG and Phillips PEM
Nature 531, 588-589 (2016) - Sub-second dopamine fluctuations in human striatum encode superposed error signals about actual and counterfactual reward
Kishida KT, Saez I, Lohrenz T, Witcher MR, Laxton AW, Tatter SB, White JP, Ellis TL, Phillips PEM and Montague PR
Proceedings of the National Academy of Sciences of the United States of America 113, 200-205 (2016) - Stress effects on the neural substrates of motivated behavior
Hollon NG, Burgeno LM and Phillips PEM
Nature Neuroscience 18, 1405-1412 (2015) - Kappa opioid receptor induced aversion requires p38 MAPK activation in VTA dopamine neurons
Ehrich JM, Messinger DI, Knakal C, Kuhar JR, Schattauer SS, Bruchas MR, Zweifel LS, Kieffer BL, Phillips PEM and Chavkin C
Journal of Neuroscience 35, 12917-12931 (2015) - Repeated stress exposure causes strain-dependent shifts in the behavioral economics of cocaine in rats
Groblewski PA, Zietz C, Willuhn I, Phillips PEM and Chavkin C
Addiction Biology 20, 297-301 (2015) - Cocaine increases dopaminergic neuron and motor activity via midbrain α1 adrenergic signaling
Goertz RB, Wanat MJ, Phillips PEM and Paladini CA
Neuropsychopharmacology 40, 1151-1162 (2015) - Fast-scan cyclic voltammetry in behaving animals
Arnold MM, Burgeno LM and Phillips PEM
In: Covey E and Carter M (eds) Basic Electrophysiology Methods. Oxford University Press. New York, NY (2015) - Probing the neurochemical correlates of motivation and decision making
Wassum KM and Phillips PEM
ACS Chemical Neuroscience 6, 11-13 (2015) - Dopamine-associated cached values are not sufficient as the basis for action selection
Hollon NG, Arnold MM, Gan JO, Walton ME and Phillips PEM
Proceedings of the National Academy of Sciences of the United States of America 111, 18357-18362 (2014) - Dynamic shaping of dopamine signals during probabilistic Pavlovian conditioning
Hart AS*, Clark JJ* and Phillips PEM
Neurobiology of Learning and Memory 117, 84-92 (2014) - Phasic dopamine release in the nucleus accumbens in response to pro-social 50-kHz ultrasonic vocalizations in rats
Willuhn I, Tose A, Wanat MJ, Hart AS, Hollon NG, Phillips PEM, Schwarting RKW and Wöhr M
Journal of Neuroscience 34, 10616-19623 (2014) - Kappa opioid receptor activation potentiates the cocaine-induced increase in evoked dopamine release recorded in vivo in the mouse nucleus accumbens
Ehrich JM, Phillips PEM and Chavkin C
Neuropsychopharmacology 30, 2026-3048 (2014) - Excessive cocaine use results from decreased phasic dopamine signaling in the striatum
Willuhn I, Burgeno LM, Groblewski PA and Phillips PEM
Nature Neuroscience 17, 704-709 (2014) - Genetic variation in COMT activity impairs learning and dopamine release capacity in the striatum
Simpson EH, Morud J, Winiger V, Biezonski D, Zhu JPQ, Malleret G, Bach ME, Polan HJ, Ng-Evans SB, Phillips PEM, Kellendonk C and Kandel ER
Learning and Memory 21, 205-214 (2014) - Phasic dopamine release in the rat nucleus accumbens symmetrically encodes a reward prediction error term
Hart AS*, Rutledge R*, Glimcher PW and Phillips PEM
Journal of Neuroscience 34, 698-704 (2014) - Prolonged dopamine signalling in striatum signals proximity and value of distant rewards
Howe MW, Tierney PL, Sandberg SG, Phillips PEM and Graybiel AM
Nature 500, 575-579 (2013) - Direct pathway striatal neurons regulate the retention of decision-making strategies
Ferguson SM, Phillips PEM, Roth BL, Wess J and Neumaier JF
Journal of Neuroscience 33, 11668-11676 (2013) - CRF acts in the midbrain to attenuate accumbens dopamine release to rewards but not their predictors
Wanat MJ, Bonci A and Phillips PEM
Nature Neuroscience 16, 383-385 (2013) - Dopamine encoding of Pavlovian incentive stimuli diminishes with extended training
Clark JJ, Collins AL, Sanford CA and Phillips PEM
Journal of Neuroscience 33, 3526-3532 (2013) - Over-inhibition of corticostriatal activity following prenatal cocaine exposure
Wang W, Nitulescu I, Lewis JS, Lemos JC, Bamford IJ, Posielski NM, Storey GP, Phillips PEM and Bamford NS
Annals of Neurology 73, 355-369 (2013) - Hierarchical recruitment of phasic dopamine signaling in the striatum during the progression of cocaine use
Willuhn I, Burgeno LM, Everitt BJ and Phillips PEM
Proceedings of the National Academy of Sciences of the United States of America 109, 20703-20708 (2012) - Severe stress switches CRF action in the nucleus accumbens from appetitive to aversive
Lemos JC, Wanat MJ, Smith JS, Reyes BAS, Hollon NG, Van Bockstaele EJ, Chavkin C and Phillips PEM
Nature 490, 402-406 (2012) - Repeated stress dysregulates kappa opioid receptor signaling in the dorsal raphe through a p38α MAPK dependent mechanism
Lemos JC, Roth CA, Messinger DI, Gill HK, Phillips PEM and Chavkin C
Journal of Neuroscience 32, 12325-12336 (2012) - Pavlovian valuation systems in learning and decision making
Clark JJ, Hollon NG and Phillips PEM
Current Opinion in Neurobiology 22, 1054ñ1061 (2012) - Altered risk-based decision making following adolescent alcohol use results from an imbalance in reinforcement learning in rats
Clark JJ*, Nasrallah N*, Hart AS, Collins AL, Bernstein IL and Phillips PEM
PLoS One 7, e37357 (2012) - Neuroeconomics
Phillips PEM, Kim JJ and Lee D
Frontiers in Behavioral Neuroscience 6, 15 (2012) - The influence of dopamine in generating action from motivation
Walton ME, Gan JO and Phillips PEM
In: Mars RB, Sallet J, Rushworth MFS, Yeung N (ed) Neural Basis of Motivational and Cognitive Control. MIT Press, Cambridge, MA (2011) - Sub-second dopamine detection in human striatum
Kishida KT*, Sandberg SG*, Lohrenz T, Comair YG, Saez I, Phillips PEM and Montague PR
PLoS One 6, e23291 (2011) - Risk preference following adolescent alcohol use is associated with corrupted encoding of costs but not rewards by mesolimbic dopamine
Nasrallah N*, Clark JJ*, Collins AL, Phillips PEM and Bernstein IL
Proceedings of the National Academy of Sciences of the United States of America 108, 5466-5471 (2011) - A selective role for dopamine in stimulus-reward learning
Flagel SB*, Clark JJ*, Robinson TE, Mayo L, Czuj A, Willuhn I, Akers CA, Clinton SM, Phillips PEM and Akil H
Nature 469, 53-57 (2011) - Transient neuronal inhibition reveals opposing roles of indirect and direct pathways in sensitization
Ferguson SM, Eskenazi D, Ishikawa M, Wanat MJ, Phillips PEM, Dong Y, Roth BL and Neumaier JF
Nature Neuroscience 14, 22-24 (2011) - Dopamine signaling in the nucleus accumbens of animals self-administering drugs of abuse
Willuhn I, Wanat MW, Clark JJ and Phillips PEM
Current Topics in Behavioral Neuroscience 3, 29-71 (2010) - Delays conferred by escalating costs modulate dopamine release to rewards but not their predictors
Wanat MJ, Kuhnen CM and Phillips PEM
Journal of Neuroscience, 30, 12020-12027 (2010) - Absence of NMDA receptors in dopamine neurons attenuates dopamine release but not Pavlovian conditioning
Parker JG, Zweifel LS, Clark JJ, Evans SB, Phillips PEM and Palmiter RD
Proceedings of the National Academy of Sciences of the United States of America, 107, 13491-13496 (2010) - Control of extracellular dopamine at dendrite and axon terminals
Ford CP, Ganz SC, Phillips PEM and Williams JT
Journal of Neuroscience 30, 6975-6983 (2010) - Chronic microsensors for longitudinal, subsecond dopamine detection in behaving animals
Clark JJ*, Sandberg SG*, Wanat MJ, Gan JO, Horne EA, Hart AS, Akers CA, Parker JG, Willuhn I, Martinez V, Evans SB, Stella N and Phillips PEM
Nature Methods 7, 126-129 (2010) - Dissociable cost and benefit encoding of future rewards by mesolimbic dopamine
Gan JO*, Walton ME* and Phillips PEM
Nature Neuroscience 13, 25-27 (2010) - An animal model of genetic vulnerability to behavioral disinhibition and responsiveness to reward-related cues: Implications for addiction
Flagel SB, Robinson TE, Clark JJ, Clinton SM, Watson SJ, Seeman P, Phillips PEM and Akil H
Neuropsychopharmacology 35, 388-400 (2010) - The time course of dopamine transmission in the ventral tegmental area
Ford CP, Phillips PEM and Williams JT
Journal of Neuroscience 29, 13344-13352 (2009) - Dynamic modulation of active prefrontal cortical networks by dopamine
Kroener S, Chandler LJ, Phillips PEM and Seamans JK
PLoS One 4 e6507 (2009) - Controls of tonic and phasic dopamine transmission in the dorsal and ventral striatum
Zhang L, Doyon WM, Clark JJ, Phillips PEM and Dani JA
Molecular Pharmacology 76, 396-404 (2009) - CRF enhancement of GIRK channel-mediated transmission in dopamine neurons
Beckstead MJ, Ford CP, Gantz SC, Stenzel-Poore MP, Phillips PEM, Mark GP and Williams JT
Neuropsychopharmacology 34, 1926-1935 (2009) - Disruption of NMDAR-dependent burst firing by dopamine neurons provides selective assessment of phasic dopamine-dependent behavior
Zweifel LS, Parker JG, Rainwater A, Wall VZ, Lobb CJ, Fadok JP, Kim MJ, Mizumori S, Paladini CA, Phillips PEM, and Palmiter RD
Proceedings of the National Academy of Sciences of the United States of America 106, 7281-7288 (2009) - Phasic dopamine release in appetitive behaviors and drug addiction
Wanat MJ, Willuhn I, Clark JJ and Phillips PEM
Current Drug Abuse Reviews 2, 195-213 (2009) - Neuroeconomics
Hart AS, Walton ME and Phillips PEM
Encyclopedia of Life Sciences. John Wiley & Sons. DOI: 10.1002/9780470015902.a002139939 (2009) - Phasic dopaminergic signaling: Implications for Parkinsonís disease
Sandberg SG and Phillips PEM
In: Tseng KY (ed) Cortico-subcortical Dynamics in Parkinsonís Disease. Humana Press (2009) - Representation of subjective value in the striatum
Knutson B, Delgado MR and Phillips PEM
In: Glimcher PW, Camerer CF, Fehr E and Poldrack RA (eds) Neuroeconomics: Decision Making and the Brain. Academic Press (2008) - Neurotransmitter: release
Ting JT and Phillips PEM
Wiley Encyclopedia of Chemical Biology. John Wiley & Sons. DOI: 10.1002/9780470048672.wecb385 (2008) - Monitoring Molecules in Neuroscience
Phillips PEM, Sandberg SG, Ahn S and Phillips AG (eds)
UBC Institute of Psychiatry (2008) - Corticotropin-releasing factor increases mouse ventral tegmental area dopamine neuron firing through a protein kinase C-dependent enhancement of Ih
Wanat MJ, Hopf FW, Stuber GD, Phillips PEM and Bonci A
Journal of Physiology 586, 2157-2170 (2008) - Presynaptic regulation of dendrodendritic dopamine transmission
Beckstead MJ, Ford CP, Phillips PEM and Williams JT
European Journal of Neuroscience 26, 1479-1488 (2007) - Calculating utility: preclinical evidence for cost-benefit analysis by mesolimbic dopamine
Phillips PEM, Walton ME and Jhou TC
Psychopharmacology 191, 483-495 (2007) - Weighing up the benefits of work: Behavioral and neural analyses of effort-related decision making
Walton ME, Kennerley SW, Bannerman DM, Phillips PEM and Rushworth MFS
Neural Networks 19, 1302-1314 (2006) - Cre-recombinase mediated restoration of nigrostriatal dopamine in a dopamine-deficient mouse reverses hypophagia and bradykinesia
Hnasko TS, Perez FA, Scouras AD, Stoll EA, Gale SD, Luquet S, Phillips PEM, Kremer EJ and Palmiter RD
Proceedings of the National Academy of Sciences of the United States of America 103, 8858-8863 (2006) - Psychophysiological mediators of caregiver stress and differential cognitive decline
Vitaliano PP, Echeverria D, Yi J, Phillips PEM, Young H and Siegler IC
Psychology and Aging 20, 402-411 (2005) - Mesocortical dopamine neurons operate on distinct temporal domains using multimodal signaling
Lavin A, Nogueira L, Lapish CC, Wightman RM, Phillips PEM and Seamans JK
Journal of Neuroscience 25, 5013-5023 (2005)
Sponsors
Our research is made possible by the generous support of our sponsors:
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