Projects
- Phasic dopamine in economic decision making
- Task-evoked dopamine release during compulsive drug taking
- Dopamine release during acquisition of drug-taking behavior
- Dorsal-ventral differences in task-evoked striatal dopamine release at different stages of instrumental behavior
- Effects of drugs of abuse on the dynamic control of dopamine release
- Characterization of synapsin-dependent facilitation of dopamine release
Techniques
- Fast-scan cyclic voltammetry
- Intracranial microstimulation
- Intracranial microinjection
- Viral-mediated gene transfer (in collaboration with John Neumaier)
- Drug self-administration
- Food self-administration
- Decision-making operant behavior
- Computational modeling (in collaboration with Read Montague)
Publications
- Wanat MJ, Willuhn I, Clark JJ and Phillips PEM (2009) Phasic dopamine release in appetitive behaviors and drug addiction. Current Drug Abuse Reviews, in press • PDF
- Hart AS, Walton ME and Phillips PEM (2008) Neuroeconomics. Encyclopedia of Life Sciences, in press.
- Sandberg SG and Phillips PEM (2008) Phasic dopaminergic signaling: Implications for Parkinson’s disease. In: Tseng KY (ed) Cortico-subcortical Dynamics in Parkinson’s Disease. Humana Press, Totowa, NJ, in press.
- Knutson B, Delgado MR and Phillips PEM (2008) Representation of subjective value in the striatum. In: Glimcher PW, Camerer CF, Fehr E and Poldrack RA (eds) Neuroeconomics: Decision Making and the Brain. Academic Press, New York, NY.
- Ting JT and Phillips PEM (2008) Neurotransmitter: release. Wiley Encyclopedia of Chemical Biology. John Wiley & Sons. DOI: 10.1002/9780470048672.wecb385 • pdf
- Phillips PEM, Sandberg SG, Ahn S and Phillips AG (eds) Monitoring Molecules in Neuroscience. UBC Institute of Psychiatry, Vancouver, BC, 2008.
- Wanat MJ, Hopf FW, Stuber GD, Phillips PEM and Bonci A (2008) Corticotropin-releasing factor increases mouse ventral tegmental area dopamine neuron firing through a protein kinase C-dependent enhancement of Ih. Journal of Physiology 586, 2157-2170 • pdf
- Beckstead MJ, Ford CP, Phillips PEM and Williams JT (2007) Presynaptic regulation of dendrodendritic dopamine transmission. European Journal of Neuroscience 26, 1479-1488 • pdf
- Phillips PEM, Walton ME and Jhou TC (2007) Calculating utility: preclinical evidence for cost-benefit analysis by mesolimbic dopamine. Psychopharmacology 191, 483-495 • pdf
- Walton ME, Kennerley SW, Bannerman DM, Phillips PEM and Rushworth MFS (2006) Weighing up the benefits of work: Behavioral and neural analyses of effort-related decision making. Neural Networks 19, 1302-1314 • pdf
- Hnasko TS, Perez FA, Scouras AD, Stoll EA, Gale SD, Luquet S, Phillips PEM, Kremer EJ and Palmiter RD (2006) Cre-recombinase mediated restoration of nigrostriatal dopamine in a dopamine-deficient mouse reverses hypophagia and bradykinesia. Proceedings of the National Academy of Sciences of the United States of America 103, 8858-8863 • pdf
- Vitaliano PP, Echeverria D, Yi J, Phillips PEM, Young H and Siegler IC (2005) Psychophysiological mediators of caregiver stress and differential cognitive decline. Psychology and Aging 20, 402-411 • pdf
- Lavin A, Nogueira L, Lapish CC, Wightman RM, Phillips PEM and Seamans JK (2005) Mesocortical dopamine neurons operate on distinct temporal domains using multimodal signaling. Journal of Neuroscience 25, 5013-5023 • pdf
Sponsors
Our research is made possible by the generous support of our sponsors:
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