Positions

2005 – present Associate Professor, University of Washington, Department of Pharmacy,                  Seattle, WA

2008 – present  Associate Member, Fred Hutchinson Cancer Research Center, Clinical Research Division, Seattle, WA.

Education

BS in Pharmacy, University of Pittsburgh
Pharm. D., University of North Carolina

BOARD CERTIFICATIONS

Board Certified Pharmacotherapy Specialist, #296566; 3/97, renewed 12/03

Board Certified in Oncology Pharmacotherapy, #598168; 12/98, renewed 12/06

Research Interests

• personalized dosing of medications in cancer patients
• pharmacokinetics and population pharmacokinetics
• improved medication efficacy and safety

Courses Taught

• Pharm 560: Pharmacotherapeutics I (co-coursemaster)
• Pharm 567: Cancer Pharmacotherapeutics
• Pharm 568/NURS533:  Healthcare of Cancer Survivors (co-coursemaster)
• Pharm 576: Oncology Research Rotation
• Pharm 599: Independent Student Research
• Molmed 514/Uconj 514: Molecular Medicine Seminar

ACTIVITIES

Dr. McCune is a member of the Institute for Public Health Genetics at UW, the American Society for Clinical Pharmacology and Therapeutics, and the American College of Clinical Pharmacists.  She is also a member of the NIH Developmental Therapeutics Study Section. 

PUBLICATIONS

Select Peer-reviewed Manuscripts (of 41 manuscripts)

1.   McCune JS, Friedman DL, Schuetze S, Blough D, Magbulos M, Hawkins DS.  The Influence of Age upon Ifosfamide-induced Nephrotoxicity.  Pediatr Blood Cancer. 2004; 42: 427-32.

2.   McCune JS, Hatfield AJ, Rendleman AA, Leith PO, Livingston RB, Ellis GK.  Potential of Chemotherapy-Herb Interactions in Adult Cancer Patients.  Supportive Care in Cancer, 2004 Jun;12(6):454-62.

3.   McCune JS, Risler LJ, Phillips BR, Blough D, Thummel KE, Shen DD.  Impact of CYP3A5 upon ifosfamide N-dechloroethylation.  Drug Metab Dispos, 2005 Jul;33(7):1074-81.

4.   Giaconne L, McCune JS, Maris MB, Gooley TA, Sandmaier BM, Slattery JT, Cole S, Storb RF, Nash RA, Georges GE.  Pharmacodynamics of mycophenolate mofetil after nonmyeloablative conditioning and unrelated donor hematopoietic cell transplantation.  Blood 2005 Dec 15;106(13):4381-8.

5.   McDonald GB, McCune JS, Gooley T, Batchelder A, Cole SL, Phillips BR, Ren G, Vicini P, Slattery JT.  Metabolism-based cyclophosphamide dosing and total body irradiation as myeloablative therapy for allogeneic hematopoietic cell transplant: A Phase I study.  Clin Pharmacol Ther 2005 Sept; 78 (3): 298-308.

6.   McCune JS, Games DM, Espirito JL.  Assessment of Chemotherapy related Amenorrhea and Osteoporosis in Premenopausal Breast Cancer Survivors.  J Oncol Pharm Pract 2005; 11: 37-43.

7.   McCune JS, Adams D, Phillips BR, Cole S, Homans AC, Guillot A, Iacono LC, Stewart CF. Cyclophosphamide Disposition in an Anephric Child.  Pediatr Blood Cancer 2006 Jan;46(1):99-104.

8.   Kalhorn TF, Howald WN, Cole S, Phillips B, Wang J, Slattery JT, McCune JS.  Rapid Quantitation of Cyclophosphamide Metabolites in Plasma by Liquid Chromatography-Mass Spectrometry.  J Chromatogr B Analyt Technol Biomed Life Sci. 2006 May 1;835(1-2):105-13. Epub 2006 Apr 11

9.   Salinger D, McCune JS, Ren A, Shen DD, Slattery JT, McDonald GB, Vicini P.  Development of a Novel Method for Real-time Dose Adjustment of Cyclophosphamide Using Bayesian Pharmacokinetic Modeling.  Clin Cancer Res 2006 12: 4888-4898.

10. Lupu M, McCune JS, Kuhr CS, Gooley T, Storb R.  Pharmacokinetics of oral mycophenolate mofetil in dogs: Bioavailability studies and the impact of antibiotic therapy.  Biol Blood Marrow Transplant. 2006 Dec;12(12):1352-4.

11.  Upton A, McCune JS, Kirby KA, Leisenring W, McDonald G, Batchelder A, Marr KA.  Fluconazole Coadministration Concurrent with Cyclophosphamide Conditioning May Reduce Regimen-Related Toxicity Post-myeloablative Hematopoietic Cell Transplantation.  Biol Blood Marrow Transplant. 2007 Jul;13(7):760-4. Epub 2007 Apr 30.

12. McCune JS, Batchelder A, Deeg HJ, Gooley T, Cole S, Phillips B; Schoch HG, McDonald GB.  Cyclophosphamide Following Targeted Oral Busulfan As Conditioning For Hematopoietic Cell Transplantation:  Pharmacokinetics, Liver Toxicity, And Mortality.  Biol Blood Marrow Transplant. 2007 Jul;13(7):853-62.

13. Woodahl EL, Hingorani SR, Wang J, Guthrie KA, McDonald GB, Batchelder A, Li M, Schoch HG, McCune JS.  Pharmacogenomic Associations In ABCB1 and CYP3A5 With Acute Kidney Injury and Chronic Kidney Disease After Myeloablative Hematopoietic Cell Transplantation, Pharmacogenomics J. 2008 Aug;8(4):248-55. Epub 2007 Aug 14.

14. Woodahl EL, Wang J, Heimfeld S, Sandmaier BM, O'Donnell PV, Phillips B, Risler L, McCune JS.  A novel phenotypic method to determine fludarabine triphosphate accumulation in T-lymphocytes from hematopoietic cell transplantation patient.  Cancer Chemother Pharmacol, SEP 2008 62 (4): 735-739.  Epub 2007 Nov 15.

15. Woodahl EL, Wang J, Heimfeld S, Ren AG, McCune JS.  Imatinib Inhibition Of Fludarabine Uptake In T-Lymphocytes.  Cancer Chemother Pharmacol, Epub 2008 Apr 9.

16. Woodahl EL, Wang J, Heimfeld S, McCune JS.  Intracellular Disposition Of Fludarabine In Human Natural Killer Cells.  Cancer Chemother Pharmacol, accepted for publication August 2008. (NIHMS 66833)

17. Eberly AL, Anderson GD, Bubalo JS, McCune JS.  Optimal Prevention of Busulfan-induced Seizures.  Pharmacotherapy, pending publication as of July 2008.

18. McCune JS, Salinger DH, Vicini P, Phillips B, Oglesby C, Park JR.  Pharmacokinetics of Cyclophosphamide and Metabolites in Children with Neuroblastoma.  J Clin Pharmacol, pending publication as of August 2008.

Reviews (of 10 reviews)

1    Frieze DA, McCune JS.  Current Status of Cetuximab for the Treatment of Patients with Solid Tumors.”  Ann Pharmacother. 2006 Feb;40(2):241-50. Epub 2006 Jan 1 (peer-reviewed).

2.   McCune JS.  Hematopoietic Cell Transplantation.  In:  Chisholm-Burns MA, Wells BG, Schwinghammer TL, Malone PM, Kolesar JM, Rotschafer JC, Dipiro JT, eds.  Pharmacotherapy: Principles & Practice.  First Edition.  New York.  McGraw-Hill Medical, 2007: 1447-1465. (peer-reviewed)

3.   McCune JS, Frieze DA.  Lung Cancer.  In:  DiPiro JT, Talbert RL, Yee GC, Matzke GR, Wells BG, Posey LM, eds.  Pharmacotherapy:  A Pathophysiologic Approach.  Seventh Edition.  New York:  McGraw-Hill; 2008. 

4.   McCune JS, Black D.  Hematopoietic Cell Transplantation.  In:  Koda-Kimble MA, Young LY, Kradjan WA, Guglielmo BJ, eds.  Applied Therapeutics:  The Clinical Use of Drugs.  Ninth Edition.  Baltimore:  Lippincott Williams & Wilkins; 2008:  92-1 to 92-37. 

Associate Professor
(206) 543-1412

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