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Research Advances and Awards - Catterall Lab

Structure of NaV and CaV Channels
1980-1984. Discovery, subunit structure, and functional reconstitution of Na channels
Beneski, PNAS 1980; Hartshorne, Messner, J Biol Chem 1982, 1984; Tamkun, Talvenheimo,
  J Biol Chem 1982, 1984; Hartshorne, PNAS 1985.
1984-1990. Discovery, subunit structure, and functional reconstitution of Ca channels
Curtis et al., Biochemistry 1984, 1986; Takahashi, Seagar, PNAS 1987; De Jongh, PNAS 1989, 1991,
   J Biol Chem 1990.
2011-2015. High-resolution structures of NaV and CaV channels
Structures of a bacterial Nav channel in pre-open and inactivated states. Payandeh, Nature
  2011, 2012.
Structure of a Ca selectivity filter. Tang, Gamal El-Din, Nature 2014.

Structure-Function Studies of NaV and CaV Channels
1986-2006 Na channel structure and function
The Sliding Helix model of voltage-dependent gating. Catterall, Ann Rev Biochem 1984.
The fast inactivation gate. Vassilev, Scheuer, Science 1988, PNAS 1989.
The IFM motif as the fast inactivation particle. West, Scheuer, PNAS 1992; Eaholtz, Neuron 1994.
Structural basis and mechanism for fast inactivation. Kellenberger, Scheuer, J Biol Chem 1996,
  J Gen Physiol, 1997; Rohl, Biochem 1999.
Cloning sodium channel β subunits and role as cell-adhesion molecules. Isom, Science 1992,
  Cell 1995.
Structural relationships in the voltage-gated ion channel superfamily. Yu, Science Signaling 2004.
2007-2012. Structural basis for voltage-dependent activation
Structural version of the Sliding Helix model. Yarov-Yarovoy, PNAS 2006.
Gating pore currents in sodium channels. Sokolov, Neuron 2005; Gamal El-Din, J Gen Physiol 2014.
Disulfide-locking of gating charges proves the Sliding Helix model. DeCaen, PNAS 2008,
  2009, 2011.
High-resolution structural model of the Sliding Helix mechanism. Yarov-Yarovoy, PNAS 2012.
Emerging consensus on mechanism of voltage-dependent gating. Vargas, J Gen Physiol 2013.
1990-2002. Molecular pharmacology of NaV and CaV channels
Receptor sites for Ca antagonists. Striessnig, PNAS 1990, 1991; Hockerman, Peterson, Johnson,
  J Biol Chem 1995, 1997a,b; PNAS, 1997.
Receptor site for local anesthetics, antiarrhythmics, and anticonvulsants on Na channels.
  Ragsdale, McPhee, Science 1994, PNAS 1995; Yarov-Yarovoy, J Biol Chem 2001, 2002.

Regulation of NaV and CaV Channels
1989-2015. Physiological regulation through Na and Ca channel signaling complexes
Differential subcellular localization of Na and Ca channel subtypes. Westenbroek, Neuron 1989;
  Nature 1990.
Modulation of fast and slow inactivation by protein phosphorylation. West, Numann, Scheuer,
  Science 1991a,b; Li, Science 1993; Chen, Neuron 2006.
Diversity and localization of neuronal Ca channels. Dubel, PNAS 1992; Westenbroek, Ahlijanian,
  Hell, Neuron 1990, 1992; J Cell Biol 1993; Sakurai, Westenbroek, J Neurosci 1995; J Cell Biol 1996.
The synaptic protein interaction site on presynaptic calcium channels. Sheng, Rettig, Neuron
   1994, Nature 1996, PNAS 1997; Mochida, Neuron 1996; Rettig, J Neurosci 1997.
Regulation of presynaptic calcium channels by G protein βγ subunits. Herlitze, Nature 1996, PNAS
Facilitation and inactivation of presynaptic Ca channels by Ca and Ca sensor proteins. Lee,
  Nature 1999, J Neurosci 2000, Nature Neurosci 2002, PNAS 2003; Lautermilch, Few J Neurosci
Presynaptic Ca channels and short-term synaptic plasticity. Mochida, Few, Neuron 2008; Leal,
  PNAS 2012.
Discovery of AKAP15 and its role in Ca channel regulation. Gray, J Biol Chem 1997, Neuron 1998;
  Hulme, J Biol Chem 2002, PNAS 2003.
Molecular mechanism of Ca channel regulation in the fight-or-flight response. Hulme, J Physiol
  2006; Fuller, Emrick, Science Signaling 2010, PNAS 2010; Fu, PNAS 2013, 2014.

Pathophysiology of NaVand CaV Channels
2006-2015. Sodium channels and disease
Impaired excitability of inhibitory Neurons in Dravet Syndrome. Yu, Nature Neurosci 2006; Cheah,
  PNAS 2012; Rubinstein, Han, Tai, Brain 2015.
Pathogenic gating-pore current in hypokalemic periodic paralysis. Sokolov, Nature 2007,
  PNAS 2008.
Autism in Dravet Syndrome mice. Han, Nature 2012, Neuron 2014.

Research Awards and Prizes
1981   Passano Foundation Young Scientist Award
1992   Basic Science Prize, American Heart Association
1995   Henry Van Dyke Award in Pharmacology, Columbia University
1995   Mathilde Solowey Award in Neuroscience, National Institutes of Health
1997   McKnight Foundation Senior Neuroscience Investigator Award
2003   Bristol-Myers Squibb Award for Distinguished Achievement in Neuroscience
2010   Robert Schwab Award, American Clinical Neurophysiology Society
2010   Gairdner International Award of Canada
2010   Ilse & Helmut Wachter Stiftung, University of Innsbruck
2011   George Palade Award, Wayne State University
2011   Gordon K. Moe Award, Cardiac Electrophysiology Society
2013   Sharpey-Shafer Prize, The Physiological Society
2014   Biomedical Research Achievement Award, Leaders in Healthcare, Seattle Business Weekly 2015   K. S. Cole Award in Membrane Biophysics, Biophysical Society
            Shared by Todd Scheuer and William A. Catterall