I’m interested in understanding the functional and structural basis of diseases caused by missense mutations in voltage-gated ion channels. I’m particularly interested in channelopathy of voltage-gated sodium and calcium ion channels. These include diseases of the nervous system (e.g., epilepsy, familial hemiplegic migraine, episodic ataxia), the muscular system (e.g. hyperkalemic and hypokalemic periodic paralysis), the cardiovascular system (e.g., long QT syndrome, short QT syndrome, Brugada syndrome).
Thousands of diseases have been attributed to ion channels in the last few decades. Thus my second main interest is to improve the affinity and efficacy of classical drugs which are still used to treat these illnesses, and to develop new medications that will target a specific subtype of an ion channel and thus reducing off-target symptoms.