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Rachel Klevit,

Lab Website

Box 357350
HSB K-466A

Office: 206.543.5891
Fax: 206.543.8394







Dr. Rachel Klevit is a Professor of Biochemistry, an Adjunct Professor of Chemistry and director of the Interdisciplinary Graduate Program in Biomolecular Structure and Design. Research in Dr. Klevit's laboratory is directed towards an understanding of molecular recognition, with an emphasis on protein-protein interactions that play important roles in human disease. A variety of structural, biochemical, molecular biological, and biophysical techniques are used in the Klevit laboratory, with a major emphasis on high resolution NMR spectroscopy and mass spectrometry. Ongoing projects in the group include the following systems: BRCA1, the breast cancer susceptibility protein; protein ubiquitination in general; human small heat shock proteins alpha-B crystallin and HSP27; and PhoQ, a virulence factor in pathogenic bacteria.

Recent Publications 

Two functionally distinct E2/E3 pairs coordinate sequential ubiquitination of a common substrate in Caenorhabditis elegans development. - ABSTRACT

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